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pro vyhledávání: '"T H Samuel, Tan"'
Publikováno v:
Org. Biomol. Chem.. 5:249-259
Pyrrolidine-amide oligonucleotide mimics (POMs) exhibit promising properties for potential applications, including in vivo DNA and RNA targeting, diagnostics and bioanalysis. Before POMs can be evaluated in these applications it is first necessary to
Autor:
Jordi Morral, Roberta J. Worthington, Jason Micklefield, T. H. Samuel Tan, Robin G. Pritchard
Publikováno v:
Organicbiomolecular chemistry. 5(2)
By chemically modifying or replacing the backbone of oligonucleotides it is possible to modulate the DNA and RNA recognition properties and fine-tune the physiochemical properties of oligomers. This is important because it challenges our understandin
Publikováno v:
Chemical communications (Cambridge, England). (5)
Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.
Autor:
David T, Hickman, T H Samuel, Tan, Jordi, Morral, Paul M, King, Matthew A, Cooper, Jason, Micklefield
Publikováno v:
Organicbiomolecular chemistry. 1(19)
Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone. Molecular modelling reveals that the lowest energy conform
Publikováno v:
Chemical Communications. :1436
The introduction of (7'S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7'R)-methylation disrupts hybridisation significant
Publikováno v:
Chemical Communications. :516
Adeninyl POM was prepared using solid-phase peptide chemistry and shown to exhibit higher affinity for complementary DNA and RNA than the corresponding adeninyl PNA.
Autor:
T. H. Samuel Tan, Jordi Morral, Paul M. King, Jason Micklefield, David T. Hickman, Mark E. Cooper
Publikováno v:
Organic & Biomolecular Chemistry. 1:3277
Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone. Molecular modelling reveals that the lowest energy conform
Publikováno v:
Chemical Communications; Mar2006, Vol. 2006 Issue 13, p1436-1438, 3p