Zobrazeno 1 - 10 of 26 pro vyhledávání: '"T H Ottenhoff"'
1
HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs
Autor: A Geluk, K E van Meijgaarden, S Southwood, C Oseroff, J W Drijfhout, R R de Vries, T H Ottenhoff, A Sette
Publikováno v: The Journal of Immunology. 152:5742-5748
Three different HLA-DR3-specific peptide binding motifs have been proposed. These motifs shared a major hydrophobic anchor at the N-terminus, but differed in the C-terminal anchor residues. In the present study, the structural requirements for peptid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1c6c0f34caca227d6e02fe4d46f4147
https://doi.org/10.4049/jimmunol.152.12.5742
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2
Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides
Autor: A Geluk, K E Van Meijgaarden, A A Janson, J W Drijfhout, R H Meloen, R R De Vries, T H Ottenhoff
Publikováno v: The Journal of Immunology. 149:2864-2871
We have previously shown that p3-13 (KTIAY-DEEARR) of the 65-kDa heat shock protein (hsp65) of Mycobacterium tuberculosis and Mycobacterium leprae is selected as an important T cell epitope in HLA-DR17+ individuals, by selectively binding to (a pocke
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fee28e15f39fbb6900031a9f9a1af982
https://doi.org/10.4049/jimmunol.149.9.2864
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3
[Research into new methods for diagnosing, treating and preventing tuberculosis]
Autor: M W, Borgdorff, A, Kolk, D, van Soolingen, J W, van der Meer, T H, Ottenhoff
Publikováno v: Nederlands tijdschrift voor geneeskunde. 147(38)
Tuberculosis control requires improved diagnostics, drugs, and vaccines. Their development is facilitated by progress in immunology, molecular biology, and genomics. In addition to sputum smear and culture, amplification techniques can already be use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::573cf9380f2fb49739da0813b56839ae
https://pubmed.ncbi.nlm.nih.gov/14533491
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4
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65
Autor: J, Charo, A, Geluk, M, Sundbäck, B, Mirzai, A D, Diehl, K J, Malmberg, A, Achour, S, Huriguchi, K E, van Meijgaarden, J W, Drijfhout, N, Beekman, P, van Veelen, F, Ossendorp, T H, Ottenhoff, R, Kiessling
Publikováno v: European journal of immunology. 31(12)
Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell respon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7aba4545c4854831094038628bc184de
https://pubmed.ncbi.nlm.nih.gov/11745380
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5
Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes
Autor: S H, van der Burg, M E, Ressing, K M, Kwappenberg, A, de Jong, K, Straathof, J, de Jong, A, Geluk, K E, van Meijgaarden, K L, Franken, T H, Ottenhoff, G J, Fleuren, G, Kenter, C J, Melief, R, Offringa
Publikováno v: International journal of cancer. 91(5)
Tumor-specific T-helper (Th) immunity was found to play a pivotal role in the natural and vaccine-induced immune defense against tumors. Since the majority of cervical cancers express human papillomavirus type 16 (HPV16) E7 oncoprotein, it is importa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5e56cc920b06b6dbacdfd934d6cf013
https://pubmed.ncbi.nlm.nih.gov/11267969
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6
[From gene to disease; mutations in interleukin-12-receptor-beta 1- and interferon-gamma-receptor-1 lead to nontuberculous mycobacterial infections and salmonellosis]
Autor: J T, van Dissel, T H, Ottenhoff
Publikováno v: Nederlands tijdschrift voor geneeskunde. 144(38)
In patients with severe and relapsing infections with non-tuberculous mycobacteria and Salmonella autosomal recessive as well as dominant-negative mutations are shown in genes for receptors of type-1 cytokines: the IL-12 receptor and the IFN-gamma re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2caba012c974aca2f2374f3751b37c5
https://pubmed.ncbi.nlm.nih.gov/11020837
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7
Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells
Autor: C E, Verhagen, de Boer T, H H, Smits, F A, Verreck, E A, Wierenga, M, Kurimoto, D A, Lammas, D S, Kumararatne, O, Sanal, F P, Kroon, van Dissel JT, F, Sinigaglia, T H, Ottenhoff
Publikováno v: The Journal of Experimental Medicine
Genetic lack of interleukin 12 receptor beta1 (IL-12Rbeta1) surface expression predisposes to severe infections by poorly pathogenic mycobacteria or Salmonella and causes strongly decreased, but not completely abrogated, interferon (IFN)-gamma produc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b0de4b748548e229dda3aac351d9d4a
https://pubmed.ncbi.nlm.nih.gov/10952721
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8
Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules
Autor: S H, van der Burg, K M, Kwappenberg, A, Geluk, M, van der Kruk, O, Pontesilli, E, Hovenkamp, K L, Franken, K E, van Meijgaarden, J W, Drijfhout, T H, Ottenhoff, C J, Melief, R, Offringa
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(1)
CD4+ Th cells play an important role in the induction and maintenance of specific T cell immunity. Indications for a protective role of CD4+ T cells against HIV-1 infection were found in subjects who were able to control HIV-1 viremia as well as in h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0a8ddec55fc566b709f9d20a022df33
https://pubmed.ncbi.nlm.nih.gov/9886381
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10
IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease
Autor: R, de Jong, A A, Janson, W R, Faber, B, Naafs, T H, Ottenhoff
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(2)
IL-12 secretion by APC is critical for the development of protective Th1-type responses in mycobacterial (Mycobacterium avium and Mycobacterium tuberculosis) infections in mice. We have studied the role of IL-12 and IL-2 in the generation of Mycobact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3e7d85a31a5f646a3cfbb8ef033b679
https://pubmed.ncbi.nlm.nih.gov/9218596
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