Zobrazeno 1 - 10 of 61 pro vyhledávání: '"T H M, Ottenhoff"'
1
Akademický článek
Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections
Autor: M. T. Heemskerk, C. J. Korbee, J. J. Esselink, C. Carvalho dos Santos, S. van Veen, I. F. Gordijn, F. Vrieling, K. V. Walburg, C. G. Engele, K. Dijkman, L. Wilson, F. A. W. Verreck, T. H. M. Ottenhoff, M. C. Haks
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The persistent increase of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) infections negatively impacts Tuberculosis treatment outcomes. Host-directed therapies (HDT) pose an complementing strategy, particularly since Mtb is high
Externí odkaz: https://doaj.org/article/1ec152b467db4abebb49dc8f7a4e9c3c
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2
Akademický článek
Use of resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia
Autor: W. van Loon, M. P. Gomez, D. Jobe, K. L. M. C. Franken, T. H. M. Ottenhoff, M. Coninx, L. Kestens, J. S. Sutherland, B. Kampmann, L. D. Tientcheu
Publikováno v: BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Interferon-γ release assays (IGRA) with Resuscitation promoting factor (Rpf) proteins enhanced tuberculosis (TB) screening and diagnosis in adults but have not been evaluated in children. Children often develop paucibacillary TB
Externí odkaz: https://doaj.org/article/62c957adf37148d096e558e1bb4b2d3d
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3
Akademický článek
Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study.
Autor: G Biesbroek, B Kapitein, I M Kuipers, M P Gruppen, D van Stijn, T E Peros, M van Veenendaal, M H A Jansen, C W van der Zee, M van der Kuip, E G J von Asmuth, M G Mooij, M E J den Boer, G W Landman, M A van Houten, D Schonenberg-Meinema, A M Tutu van Furth, M Boele van Hensbroek, H Scherpbier, K E van Meijgaarden, T H M Ottenhoff, S A Joosten, N Ketharanathan, M Blink, C L H Brackel, H L Zaaijer, P Hombrink, J M van den Berg, E P Buddingh, T W Kuijpers
Publikováno v: PLoS ONE, Vol 17, Iss 11, p e0266336 (2022)
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD).
Externí odkaz: https://doaj.org/article/46ab18e14c1f40b2aecfdd56277b7c15
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4
Akademický článek
Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome
Autor: Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
There remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By analyzing cohorts of household contacts of TB index cases (HHCs) and a string
Externí odkaz: https://doaj.org/article/1eba36dc045c44aa95b786e37918a63e
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5
Akademický článek
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts
Autor: Fergal J. Duffy, Ethan Thompson, Katrina Downing, Sara Suliman, Harriet Mayanja-Kizza, W. Henry Boom, Bonnie Thiel, January Weiner III, Stefan H. E. Kaufmann, Drew Dover, David L. Tabb, Hazel M. Dockrell, Tom H. M. Ottenhoff, Gerard Tromp, Thomas J. Scriba, Daniel E. Zak, Gerhard Walzl, the GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. Loxton, N. N. Chegou, S. Suliman, T. Scriba, H. Mahomed, M. Erasmus, O. Xasa, A. Veldsman, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong C, W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Biomarkers that predict who among recently Mycobacterium tuberculosis (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miR
Externí odkaz: https://doaj.org/article/a450c97d56b9481c89cbc4507d35a4ef
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6
[Better vaccines against tuberculosis]
Autor: T H M, Ottenhoff
Publikováno v: Nederlands tijdschrift voor geneeskunde. 164
In the past 2 years, research on new tuberculosis vaccines and correlates of immunity against tuberculosis has led to significant breakthroughs. This gives real hope for the development and evaluation of effective, life-saving tuberculosis vaccines.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d20ef7bd225619181ae48f5dfafadf2a
https://pubmed.ncbi.nlm.nih.gov/32940985
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7
Additional file 1 of Use of resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia
Autor: W. Van Loon, M. P. Gomez, D. Jobe, K. L. M. C. Franken, T. H. M. Ottenhoff, M. Coninx, L. Kestens, J. S. Sutherland, B. Kampmann, L. D. Tientcheu
Additional file 1 Supplementary Figure 1. TST induration size versus IGRA with EC-fusion protein. Supplementary Figure 2. TST induration size versus age. Supplementary Figure 3. IGRA with EC-fusion protein versus age. Supplementary Figure 4. IFN-γ r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd4651be4cea6eb088fb3defd0b6d8c
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9
Detection of in vitro interferon-gamma and serum tumour necrosis factor-alpha in multidrug-resistant tuberculosis patients
Autor: T. H. M. Ottenhoff, K. S. Cunha, Afranio Lineu Kritski, Annemieke Geluk, C. L. M. C. Franken, Paulo R. Z. Antas, P. Klatser, K.C. Pereira, Margareth Pretti Dalcolmo, Euzenir Nunes Sarno, Elizabeth P. Sampaio, A. Fortes, M. M. Ribeiro-Carvalho, A. H. J. Kolk
Publikováno v: Clinical and experimental immunology, 141(3), 541-548. Wiley-Blackwell
SummaryMultidrug-resistant tuberculosis (MDR-TB) is known as having a poor prognosis with a weak response to therapy and very high death rates. The aim of this work was to assess the immune response to the RD1-encoded antigen ESAT-6 of Mycobacterium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38dc801a77b2ec3aa6da92d080498bf
https://doi.org/10.1111/j.1365-2249.2005.02872.x
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10
Heterogeneity in the granulomatous response to mycobacterial infection in patients with defined genetic mutations in the interleukin 12-dependent interferon-gamma production pathway
Autor: J D Edgar, Calman A. MacLennan, E De Heer, R Baretto, Dinakantha S. Kumararatne, V Novelli, J.-L. Casanova, S Panchalingam, J.F. Emile, Anne Ben-Smith, David A. Lammas, T H M Ottenhoff, J Binch, P Drysdale
Publikováno v: International Journal of Experimental Pathology. 83:1-20
Patients with genetic lesions in the Type-1 cytokine/cytokine receptor pathway exhibit a selective susceptibility to severe infections with poorly pathogenic mycobacteria and non-typhi salmonella spp. These experiments of nature demonstrate that IL-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4173cc9eb690f930395db81f1922a760
https://doi.org/10.1046/j.1365-2613.2002.00216.x
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