Výsledky vyhledávání - "T H, Rushmore"

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4

Autor: P, Lu, Y, Lin, A D, Rodrigues, T H, Rushmore, T A, Baillie, M, Shou

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(11)

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin, marker substrates for cytochrome P450 3A4 are commonly used within the pharmaceutical industry to screen new chemical entities as inhibitors of CYP3A4 in a high-throughpu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6818d04efb1aef7d7e06d2d7015c6a15
https://pubmed.ncbi.nlm.nih.gov/11602524

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Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Autor: Y, Lin, P, Lu, C, Tang, Q, Mei, G, Sandig, A D, Rodrigues, T H, Rushmore, M, Shou

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(4 Pt 1)

Most cytochrome P450 (P450 or CYP)-catalyzed reactions are adequately described by classical Michaelis-Menten kinetic parameters (e.g., Km and Vmax), which are usually determined by a saturation profile of velocity of product formation versus substra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c070c18ef222de91bffd5ec4f1532c3
https://pubmed.ncbi.nlm.nih.gov/11259318

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Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

Autor: C, Tang, M, Shou, Q, Mei, T H, Rushmore, A D, Rodrigues

Publikováno v: The Journal of pharmacology and experimental therapeutics. 293(2)

In vitro studies were conducted to identify the cytochromes P450 (CYP) involved in the oxidative metabolism of celecoxib. The hydroxylation of celecoxib conformed to monophasic Michaelis-Menten kinetics (mean +/- S.D., n = 4 livers, K(m) = 3.8 +/- 0.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb62ed14a898843046cdce6e6777bb9d
https://pubmed.ncbi.nlm.nih.gov/10773015

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Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism

Autor: Q, Mei, C, Tang, C, Assang, Y, Lin, D, Slaughter, A D, Rodrigues, T A, Baillie, T H, Rushmore, M, Shou

Publikováno v: The Journal of pharmacology and experimental therapeutics. 291(2)

Cytochrome P-450 (CYP) 3A4 is an inordinately important CYP enzyme that catalyzes the metabolism of a vast array of clinically used drugs. Microsomal proteins of Spodoptera frugiperda (Sf21) insect cells infected with recombinant baculoviruses encodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a91d95cd6ad9742db2a69783f766fe4e
https://pubmed.ncbi.nlm.nih.gov/10525096

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Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

Autor: M, Shou, Q, Mei, M W, Ettore, R, Dai, T A, Baillie, T H, Rushmore

Publikováno v: The Biochemical journal. 340

Cytochrome P450 3A4 (CYP3A4) plays a prominent role in the metabolism of a vast array of drugs and xenobiotics and exhibits broad substrate specificities. Most cytochrome P450-mediated reactions follow simple Michaelis-Menten kinetics. These paramete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f535eaeac77aa489ce447a9248e6b3c9
https://pubmed.ncbi.nlm.nih.gov/10359672

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Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites

Autor: W, Tang, R A, Stearns, S M, Bandiera, Y, Zhang, C, Raab, M P, Braun, D C, Dean, J, Pang, K H, Leung, G A, Doss, J R, Strauss, G Y, Kwei, T H, Rushmore, S H, Chiu, T A, Baillie

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(3)

The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal hepatotoxicity that may be associated with the formation of reactive metabolites. In this study, three glutathione (GSH) adducts, namely 5-hydroxy-4-(glutathion-S-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b96ad3ee02ebc70a64ca18b2eab52cae
https://pubmed.ncbi.nlm.nih.gov/10064567

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Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence

Autor: K C, Falkner, T H, Rushmore, M W, Linder, R A, Prough

Publikováno v: Molecular pharmacology. 53(6)

Glucocorticoids (GCs) repress both basal and polyaromatic hydrocarbon-induced expression of the glutathione S-transferase Ya1 gene (gstA2) in isolated rat hepatocytes and rat liver in vivo. Transient transfection experiments with HepG2 cells were use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbb47e1f739105a2e14995ed94d780bf
https://pubmed.ncbi.nlm.nih.gov/9614203

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Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents

Autor: P, Fei, G A, Matwyshyn, T H, Rushmore, A N, Kong

Publikováno v: Pharmaceutical research. 13(7)

To study the transcription regulation of rat glutathione S-transferase Ya (rGSTya) subunit gene expression by chemopreventive agents.The effects of chemopreventive agents; tamoxifen, genistein, oltipraz, indole-3-carbinol, and various isothiocyanates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbd5b338e2d39c056ce0c3c3a86891fe
https://pubmed.ncbi.nlm.nih.gov/8842042

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