Zobrazeno 1 - 10
of 129
pro vyhledávání: '"T Goodchild"'
Autor:
Jake E. Doiron, Zhen Li, Xiaoman Yu, Kyle B. LaPenna, Heather Quiriarte, Timothy D. Allerton, Kashyap Koul, Andrew Malek, Sanjiv J. Shah, Thomas E. Sharp, Traci T. Goodchild, Daniel R. Kapusta, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)
Background The renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejec
Externí odkaz:
https://doaj.org/article/377b6dd424934dd9a1525c1d2e497cee
Autor:
Axel J. Fenwick, Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, Anthony Cammarato
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a084e9b1e94b4c3c8eb42688403bb233
Autor:
Kyle B. LaPenna, Zhen Li, Jake E. Doiron, Thomas E. Sharp, Huijing Xia, Karl Moles, Kashyap Koul, John S. Wang, David J. Polhemus, Traci T. Goodchild, Ravi B. Patel, Sanjiv J. Shah, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)
Background Recent studies have suggested that cardiac nitrosative stress mediated by pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) contributes to the pathogenesis of heart failure with preserved ejection fraction (
Externí odkaz:
https://doaj.org/article/7aac073711094e04ba91e3ff73aa8fb6
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Atherosclerosis contributes to the majority of deaths related to cardiovascular disease (CVD). Recently, the nonspecific inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) has shown prognostic value in patients with CVD;
Externí odkaz:
https://doaj.org/article/884faed823e7413baf5246d4efc9121b
Autor:
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, Antonia Katsouda, John W. Elrod, Josef Pfeilschifter, Karl-Friedrich Beck, Shi Xu, Ming Xian, Traci T. Goodchild, Andreas Papapetropoulos, David J. Lefer
Publikováno v:
Circulation Research. 132:154-166
Background: Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen-sulfide–producing enzyme, is predominantly localized in the vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd52d4d0fd3dacce7901f500350f2291
https://doi.org/10.1161/circresaha.122.321326
https://doi.org/10.1161/circresaha.122.321326
Autor:
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 10 (2020)
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine
Externí odkaz:
https://doaj.org/article/22461a42020f413194074c3828bfb2fd
Autor:
Zhen, Li, Huijing, Xia, Thomas E, Sharp, Kyle B, LaPenna, John W, Elrod, Kevin M, Casin, Ken, Liu, John W, Calvert, Vinh Q, Chau, Fadi N, Salloum, Shi, Xu, Ming, Xian, Noriyuki, Nagahara, Traci T, Goodchild, David J, Lefer
Publikováno v:
Circulation research. 131(3)
Hydrogen sulfide (HHuman myocardial samples obtained from patients with heart failure undergoing cardiac surgeries were probed for 3-MST protein expression. 3-MST knockout mice and C57BL/6J wild-type mice were subjected to transverse aortic constrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2c9d8f4c0c17bc12d88be38f77e19b4
https://pubmed.ncbi.nlm.nih.gov/36173826
https://pubmed.ncbi.nlm.nih.gov/36173826
Autor:
Zhen Li, Huijing Xia, Thomas E. Sharp, Kyle B. LaPenna, John W. Elrod, Kevin M. Casin, Ken Liu, John W. Calvert, Vinh Q. Chau, Fadi N. Salloum, Shi Xu, Ming Xian, Noriyuki Nagahara, Traci T. Goodchild, David J. Lefer
Publikováno v:
Circulation Research. 131:222-235
Background: Hydrogen sulfide (H 2 S) exerts mitochondria-specific actions that include the preservation of oxidative phosphorylation, biogenesis, and ATP synthesis, while inhibiting cell death. 3-MST (3-mercaptopyruvate sulfurtransferase) is a mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2be06cd506203f0642240dbc5df8362
https://doi.org/10.1161/circresaha.121.319817
https://doi.org/10.1161/circresaha.121.319817
Autor:
Rishi K. Trivedi, David J. Polhemus, Zhen Li, Daniel Yoo, Hiroshi Koiwaya, Amy Scarborough, Traci T. Goodchild, David J. Lefer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 5 (2018)
BackgroundThere is a paucity of data about the mechanisms by which sacubitril/valsartan (also known as LCZ696) improves outcomes in patients with heart failure. Specifically, the effects of sacubitril/valsartan on vascular function and NO bioavailabi
Externí odkaz:
https://doaj.org/article/a8b1835866e64d5ca8f208f30c88a7c9
Autor:
Hunter A Hidalgo, Amy Scarborough, Zhen Li, Thomas E. Sharp, David J. Polhemus, J. Stephen Jenkins, Timothy Matsuura, Jeffery D. Schumacher, Daniel P. Kelly, David J. Lefer, Traci T. Goodchild
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • A large animal model that recapitulates the clinical heterogeneity of HFpEF has been developed. • Multiple comorbidities, including obesity, hypercholesterolemia, pre-diabetic phenotype, as well as pulmonary and
Highlights • A large animal model that recapitulates the clinical heterogeneity of HFpEF has been developed. • Multiple comorbidities, including obesity, hypercholesterolemia, pre-diabetic phenotype, as well as pulmonary and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1e0726e5da7045a1ac79cfd8108325
https://doi.org/10.1016/j.jacbts.2020.11.012
https://doi.org/10.1016/j.jacbts.2020.11.012