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Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells

Autor: T. Ghayur, Yoshinobu Manome, G. Meinhardt, R. Kamen, Surender Kharbanda, Winnie W. Wong, Ralph R. Weichselbaum, H. Kisaki, M. Robertson, Yutaka Emoto

Publikováno v: The EMBO Journal. 14:6148-6156

These studies demonstrate that treatment of human U-937 cells with ionizing radiation (IR) is associated with activation of a cytoplasmic myelin basic protein (MBP) kinase. Characterization of the kinase by gel filtration and in-gel kinase assays sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a423c7654c725d40b3cc6cebd19b550
https://doi.org/10.1002/j.1460-2075.1995.tb00305.x

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IL-1 beta converting enzyme (ICE) is not required for apoptosis induced by lymphokine deprivation in an IL-2-dependent T cell line

Autor: J P Vasilakos, T Ghayur, R T Carroll, D A Giegel, J M Saunders, L Quintal, K M Keane, B D Shivers

Publikováno v: The Journal of Immunology. 155:3433-3442

Clonal T cells undergo programmed cell death (PCD) or apoptosis when cultured without the appropriate cytokines. The cysteine protease, IL-1 beta converting enzyme (ICE), is implicated in apoptosis based on its structural similarity to the PCD gene,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df55bcde3f1ec46e336765ba3fecce27
https://doi.org/10.4049/jimmunol.155.7.3433

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Alloreactive lymphocytes from T cell receptor (beta-chain) transgenic mice do not mediate a graft-versus-host reaction

Autor: I J Rimm, T Ghayur, D L Gasser, K Rosenkrantz, S J Burakoff, J G Seidman, J L Ferrara

Publikováno v: The Journal of Immunology. 146:1130-1133

The injection of mature T cells into a tolerant or immunocompromised allogeneic host animal produces a graft versus host response (GVHR) that can result in splenomegaly, immunosuppression and death of the host animal. We demonstrate here that lymphoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53a43696a81f66ce4d4b03e5bd80e94c
https://doi.org/10.4049/jimmunol.146.4.1130

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EVIDENCE THAT ANTI-LFA-1 IN VIVO IMPROVES ENGRAFTMENT AND SURVIVAL AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION

Autor: P. J. Van Dijken, James L.M. Ferrara, Peter Mauch, JD Down, Steven J. Burakoff, T. Ghayur

Publikováno v: Transplantation. 49:882-885

The LFA-1 molecule is a member of the leukocyte adhesion complex (CD11/CD18) that is critical to adhesion and effector function of T cells and NK cells. Both T cells and NK cells play important roles in bone marrow graft rejection, and anti-LFA-1 MAb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6902047faa7f8b92580a201ac7084a0
https://doi.org/10.1097/00007890-199005000-00009

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Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production

Autor: Margaret Hugunin, Robert V. Talanian, L. Sekut, H. Allen, A. Carter, Michael Paskind, T. Ghayur, Daniel E. Tracey, D. Butler, S. Banerjee, Winnie W. Wong, Linda Herzog, L. Quintal, Robert Kamen

Publikováno v: Nature. 386(6625)

Interferon-gamma-inducing factor (IGIF, interleukin-18) is a recently described cytokine that shares structural features with the interleukin-1 (IL-1) family of proteins and functional properties with IL-12. Like IL-12, IGIF is a potent inducer of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423d0e5749342ab03b29ca7a1a62747f
https://pubmed.ncbi.nlm.nih.gov/9121587

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OP0085 Therapeutic Inhibition of Anti-Apoptotic BCL-2 Family Proteins in a Murine Model of Lupus Nephritis

Autor: P. Bardwell, D. Perron, Li Chun Wang, Andrew J. Souers, Steven W. Elmore, E. Tarcsa, S. Perper, N. Mozaffarian, T. Ghayur, L. Olson

Publikováno v: Annals of the Rheumatic Diseases. 72:A79.1-A79

Background Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed cell death, is tightly regulated by the BCL-2 family proteins. Dysregulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7602f305010744880d57bb76b25db3c6
https://doi.org/10.1136/annrheumdis-2013-eular.290

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A donor-derived asialo-GM1+ cell induces depression of B-cell genesis during systemic graft-versus-host disease

Autor: A, Xenocostas, T, Ghayur, J C, Setrakian, W S, Lapp, D G, Osmond

Publikováno v: Blood. 84(11)

The nature of the effector cell(s) responsible for the depression of B-cell genesis in the bone marrow of mice undergoing systemic graft-versus-host disease (GVHD) has been examined. Donor C57BL/6 (B6) mice were treated in vivo with either a single i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fa0e8f9f215c217bfbc1f8db7ec8010
https://pubmed.ncbi.nlm.nih.gov/7949152

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