Zobrazeno 1 - 10
of 70
pro vyhledávání: '"T Garimella"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
BackgroundBlast induced Traumatic Brain Injury (bTBI) has become a signature casualty of military operations. Recently, military medics observed neurocognitive deficits in servicemen exposed to repeated low level blast (LLB) waves during military hea
Externí odkaz:
https://doaj.org/article/371413d84ea549aba50e852e03fb882b
Autor:
Namrata S. Matharoo, Harsha T. Garimella, Carrie German, Andrzej J. Przekwas, Bozena Michniak-Kohn
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15118 (2023)
The administration of therapeutic drugs through dermal routes, such as creams and ointments, has emerged as an increasingly popular alternative to traditional delivery methods, such as tablets and injections. In the context of drug development, it is
Externí odkaz:
https://doaj.org/article/988b0933aba4449390ed5fb037aa6fbb
Autor:
Harsha T Garimella, Reuben H Kraft
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 1, Pp 23-26 (2017)
Computational models provide additional tools for studying the brain, however, many techniques are currently disconnected from each other. There is a need for new computational approaches that span the range of physics operating in the brain. In this
Externí odkaz:
https://doaj.org/article/721217c4489d4141afd69dc2b1ae19f0
Publikováno v:
Pharmaceutical Research. 40:735-747
Purpose To investigate in vitro transdermal delivery of tofacitinib citrate across human skin using microporation by microneedles and iontophoresis alone and in combination. Methods In vitro permeation studies were conducted using vertical Franz diff
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0190881 (2018)
Subject-specific computer models (male and female) of the human head were used to investigate the possible axonal deformation resulting from the primary phase blast-induced skull flexures. The corresponding axonal tractography was explicitly incorpor
Externí odkaz:
https://doaj.org/article/3832f8b05a53439a83510e18309d64f5
Publikováno v:
International journal of pharmaceutics. 628
Application of drugs on skin with compromised barrier can significantly alter permeation of drugs with the possibility of increased adverse side effects or even toxicity. In this study, we tested in vitro delivery of diclofenac sodium from marketed b
Autor:
T Garimella, Caleb Lee, Masahiro Sugihara, Junji Tsurutani, Ian E. Krop, Kazuo Tamura, J. Baselga, H. Iwata, Lin Zhang, O Yin, Antoine Yver, Russ Wada, Shanu Modi, S. Takahashi
Publikováno v:
Cancer Research. 79:P6-17
Background DS-8201a is a HER2-targeting antibody-drug conjugate with a high drug-to-antibody ratio of 7 to 8. A novel cleavable peptide-based linker joins the humanized HER2 antibody to a topoisomerase I inhibitor payload. In an ongoing phase 1 study
Autor:
Andrzej Przekwas, Harsha T. Garimella, Carrie L. German, Debarun Das, Laurent Simon, Mahadevabharath R. Somayaji
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 167
The delivery of therapeutic drugs through the skin is a promising alternative to oral or parenteral delivery routes because dermal drug delivery systems (D3S) offer unique advantages such as controlled drug release over sustained periods and a signif
Publikováno v:
Computer methods in biomechanics and biomedical engineering. 23(11)
Neck pain is a major inhibitor affecting the performance of U.S. military personnel. Repetitive exposure to cyclic loading due to military activities over several years can lead to accumulation of fatigue damage in the cervical intervertebral disc an
Fast-Running Tools for Personalized Monitoring of Blast Exposure in Military Training and Operations
Autor:
Tim Zehnbauer, Walter Carr, Raj K. Gupta, Andrzej Przekwas, Maciej Skotak, Z. J. Chen, Gary H. Kamimori, Harsha T. Garimella
Publikováno v:
Military medicine. 186(Suppl 1)
Introduction During training and combat operations, military personnel may be exposed to repetitive low-level blast while using explosives to gain entry or by firing heavy weapon systems such as recoilless weapons and high-caliber sniper rifles. This