Zobrazeno 1 - 10 of 23 pro vyhledávání: '"T G Hammond"'
1
Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT
Autor: M H, Bridgland-Taylor, A C, Hargreaves, A, Easter, A, Orme, D C, Henthorn, M, Ding, A M, Davis, B G, Small, C G, Heapy, N, Abi-Gerges, F, Persson, I, Jacobson, M, Sullivan, N, Albertson, T G, Hammond, E, Sullivan, J-P, Valentin, C E, Pollard
Publikováno v: Journal of Pharmacological and Toxicological Methods. 54:189-199
Regulatory and competitive pressure to reduce the QT interval prolongation risk of potential new drugs has led to focus on methods to test for inhibition of the human ether-a-go-go-related gene (hERG)-encoded K+ channel, the primary molecular target
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03365662b18fdce884939590e0b357f2
https://doi.org/10.1016/j.vascn.2006.02.003
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2
FK506-Induced Endothelin Release by Cultured Rat Mesangial Cells
Autor: T. G. Hammond, C. N. Kind, T. Goodall
Publikováno v: Journal of Cardiovascular Pharmacology. 26:S482-485
Renal damage is a major side effect of the macrolide immunosuppressant FK 506. Although little is known about the underlying mechanism of FK 506 nephrotoxicity, available data suggest that it may be associated with a disturbance in renal hemodynamics
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::075de39135a2a20f0de023ce3aaddbfd
https://doi.org/10.1097/00005344-199506263-00142
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3
An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk
Autor: Chris E, Pollard, N, Abi Gerges, M H, Bridgland-Taylor, A, Easter, T G, Hammond, J-P, Valentin
Publikováno v: British journal of pharmacology. 159(1)
Owing to its association with Torsades de Pointes, drug-induced QT interval prolongation has been and remains a significant hurdle to the development of safe, effective medicines. Genetic and pharmacological evidence highlighting the pivotal role the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f54ff7c21c8d505414286241dabc455
https://pubmed.ncbi.nlm.nih.gov/20141517
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5
A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes
Autor: C L, Lawrence, M H, Bridgland-Taylor, C E, Pollard, T G, Hammond, J-P, Valentin
Publikováno v: British journal of pharmacology. 149(7)
The rabbit isolated Langendorff heart model (SCREENIT) was used to investigate the proarrhythmic potential of a range of marketed drugs or drugs intended for market. These data were used to validate the SCREENIT model against clinical outcomes.Fifty-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44ac7ac5c0bb79dca9deec114256322b
https://pubmed.ncbi.nlm.nih.gov/17031389
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6
Extracellular mass transport considerations for space flight research concerning suspended and adherent in vitro cell cultures
Autor: David M, Klaus, Michael R, Benoit, Emily S, Nelson, T G, Hammond
Publikováno v: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. 11(1)
Conducting biological research in space requires consideration be given to isolating appropriate control parameters. For in vitro cell cultures, numerous environmental factors can adversely affect data interpretation. A biological response attributed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c2db13c1a2f5e18e704a141dc8a7fc9
https://pubmed.ncbi.nlm.nih.gov/16145796
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7
Use of in vitro methods to predict QT prolongation
Autor: Chris Pollard, T G Hammond
Publikováno v: Toxicology and applied pharmacology. 207
The inhibition of the hERG-encoded potassium channel can lead to prolongation of the cardiac action potential--manifested as a prolongation of the QT interval on the ECG. Although QT interval prolongation is not dangerous per se, in a small percentag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bed6d261701e2e60beb30543a4f60d6
https://pubmed.ncbi.nlm.nih.gov/16023163
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9
Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder
Autor: X C, Wang, R, Saban, J H, Kaysen, M R, Saban, P L, Allen, E N, Benes, T G, Hammond
Publikováno v: The Journal of urology. 163(3)
The proteins which constitute the final common pathway linking receptors on cell surfaces to the inflammatory cascade have recently been identified and cloned. Central to activation of this inflammatory cascade is translocation from cytosol to nucleu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e63c976bd4155e629c93258cb31cb098
https://pubmed.ncbi.nlm.nih.gov/10688037
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10
Salmonella efficiently enter and survive within cultured CD11c+ dendritic cells initiating cytokine expression
Autor: I, Marriott, T G, Hammond, E K, Thomas, K L, Bost
Publikováno v: European journal of immunology. 29(4)
While Salmonella infects macrophages, this cell population may not be the only one important for disseminating intracellular bacteria from mucosal sites. Dendritic cells (DC) are present in the Peyer's patches and are mobilized following stimulation.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ca9a454365f0ac9acde43b01427b915
https://pubmed.ncbi.nlm.nih.gov/10229077
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