Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo: non-equivalence with pharmacological activity

Autor: P S, DiStefano, T G, Boulton, J L, Stark, Y, Zhu, K M, Adryan, T E, Ryan, R M, Lindsay

Publikováno v: The Journal of biological chemistry. 271(37)

Despite the widespread use of polypeptide growth factors as pharmacological agents, little is known about the extent to which these molecules regulate their cognate cell surface receptors and signal transduction pathways in vivo. We have addressed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3ed8f7ff006644e3975ee4beb617ca2
https://pubmed.ncbi.nlm.nih.gov/8798462

The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor

Autor: N, Stahl, T G, Boulton, N, Ip, S, Davis, G D, Yancopoulos

Publikováno v: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 27(2)

Many proteins with a variety of functions have proven to have glycosylphosphatidylinositol (GPI)-linkages; two members of this family are the scrapie prion protein and the receptor for ciliary neurotrophic factor (CNTF). The scrapie prion protein has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28f770d134368887e8ee6bcaaa67e51d
https://pubmed.ncbi.nlm.nih.gov/8081242

An insulin-stimulated ribosomal protein S6 kinase from rabbit liver

Autor: J S, Gregory, T G, Boulton, B C, Sang, M H, Cobb

Publikováno v: The Journal of biological chemistry. 264(31)

In this report we describe an activated form of S6 protein kinase in rabbits treated acutely with insulin. The major insulin-stimulated activity in rabbit liver is increased 2- to 5-fold compared to material from untreated animals based on DEAE-cellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b9b9d8f6f72fb609d3249888f787013
https://pubmed.ncbi.nlm.nih.gov/2553707

Circadian Control of Protein Synthesis.

Autor: James NR; Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, UK., O'Neill JS; Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge, UK.

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Dec 12, pp. e202300158. Date of Electronic Publication: 2024 Dec 12.

Evaluating the IL-6 Family of Cytokines Throughout Equine Gestation.

Autor: Fedorka CE; Department of Animal Sciences, Colorado State University, Fort Collins, Colorado, USA., Scoggin KE; Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA., El-Sheikh Ali H; Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA., Troedsson MHT; Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA.

Publikováno v: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2024 Jul; Vol. 92 (1), pp. e13910.