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Akademický článek

Site-specific analysis of protein S-acylation by resin-assisted capture[S]

Autor: Michael T. Forrester, Douglas T. Hess, J. Will Thompson, Rainbo Hultman, M. Arthur Moseley, Jonathan S. Stamler, Patrick J. Casey

Publikováno v: Journal of Lipid Research, Vol 52, Iss 2, Pp 393-398 (2011)

Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is converted to a thioester. A prototype is S-palmitoylation (fatty acylation), in which a protein undergoes acylation with a hydrophobic 16 carbon lipid chain. Al

Externí odkaz: https://doaj.org/article/2f7b93eb409b49f38595ffb502bbfe7a

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Akademický článek

Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology

Autor: Michael T. Forrester, Christine E. Eyler, Jeremy N. Rich

Publikováno v: BioTechniques, Vol 50, Iss 1, Pp 41-45 (2011)

A wide range of mammalian signaling and stress pathways are mediated by nitric oxide (NO), which is synthesized in vivo by the nitric oxide synthase (NOS) family of enzymes. Experimental manipulations of NO are frequently achieved by either inhibitio

Externí odkaz: https://doaj.org/article/1b397c90bdf04c3885fb70578edba266

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Akademický článek

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ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity

Autor: Harvey E. Marshall, Michael T. Forrester, Zachary T. Kelleher, Chunbo Wang, Matthew W. Foster

Publikováno v: J Biol Chem

Dynamic control of thioredoxin (Trx) oxidoreductase activity is essential for balancing the need of cells to rapidly respond to oxidative/nitrosative stress and to temporally regulate thiol-based redox signaling. We have previously shown that cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed95cf3798136854df896bdb50e97a5
https://doi.org/10.1074/jbc.ra119.007733

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Abstract P6-16-01: Health-related quality of life in MONARCH 3: Abemaciclib plus an aromatase inhibitor as initial therapy in women with HR+, HER2- advanced breast cancer

Autor: A DiLeo, Jens Huober, Matthew P. Goetz, Lang Li, J. Gable, Eriko Tokunaga, Gregory L Price, T. Forrester, Gebra Cuyun Carter, C Gainford, M.E. Boye, A Sood, In Hae Park, M. Martin, M. Toi, S.R.D. Johnston

Publikováno v: Cancer Research. 79:P6-16

Background: In the MONARCH 3 trial, abemaciclib plus an aromatase inhibitor (AI) significantly improved progression free survival and overall response rate with a generally tolerable safety profile compared to placebo plus AI. Here we report patient-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f617e5ed814e0ce70eddd683f4e6e931
https://doi.org/10.1158/1538-7445.sabcs18-p6-16-01

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Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

Autor: N. Harbeck, P. Rastogi, M. Martin, S.M. Tolaney, Z.M. Shao, P.A. Fasching, C.S. Huang, G.G. Jaliffe, A. Tryakin, M.P. Goetz, H.S. Rugo, E. Senkus, L. Testa, M. Andersson, K. Tamura, L. Del Mastro, G.G. Steger, H. Kreipe, R. Hegg, J. Sohn, V. Guarneri, J. Cortés, E. Hamilton, V. André, R. Wei, S. Barriga, S. Sherwood, T. Forrester, M. Munoz, A. Shahir, B. San Antonio, S.C. Nabinger, M. Toi, S.R.D. Johnston, J. O’Shaughnessy, M.M. Jimenez, S. Johnston, F. Boyle, P. Neven, Z. Jiang, M. Campone, J. Huober, C. Shimizu, I. Cicin, A. Wardley, G.G. Abuin, J. Zarba, E. Lim, P. Sant, N. Liao, B. Christiansen, N. Eigeliene, J. Martin-Babau, J. Ettl, D. Mavroudis, J. Chiu, K. Boer, R. Nagarkar, S. Paluch-Shimon, L. Moscetti, Y. Sagara, S.-B. Kim, M.M. Maciel, V. Tjan-Heijnen, R. Broom, A. Lacko, M. Schenker, N. Volkov, Y. Sim Yap, M. Coccia-Portugal, J. Ángel García Sáenz, A. Andersson, T.-Y. Chao, E. Gokmen, H. Harputluoglu, O. Berzoy, D. Patt, H. McArthur, H. Chew, P. Chalasani, P. Kaufman, K. Tedesco, S.L. Graff

Publikováno v: Scientia
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)

Abemaciclib; Adjuvant; Early breast cancer Abemaciclib; Adjuvant; Càncer de mama precoç Abemaciclib; Adyuvante; Cáncer de mama precoz Background Adjuvant abemaciclib combined with endocrine therapy (ET) previously demonstrated clinically meaningfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8f034d3b29209a723a645cb0a3caf0
https://hdl.handle.net/11268/11356

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