Zobrazeno 1 - 10
of 37
pro vyhledávání: '"T F McDonald"'
Autor:
T. F. McDonald, A. B. Chandler
The processes of distention and recoil have an essential role in the functions of arteries and lungs. In both organ systems, these processes involve to a great extent the connective tissues, in particular the manner in which the extracellular materia
Publikováno v:
The Journal of Physiology. 424:205-228
1. Whole-cell calcium current (ICa) was recorded in guinea-pig ventricular myocytes superfused with Na+,K(+)-free solution and dialysed with a substrate-free solution (minimum intracellular solution, MICS). A dual tight-seal pipette method was often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6147b7e8c529f49b52e30c9056784978
https://doi.org/10.1113/jphysiol.1990.sp018063
https://doi.org/10.1113/jphysiol.1990.sp018063
Publikováno v:
British journal of pharmacology. 131(8)
Previous studies on verapamil and D600 have established that the Ca(2+)-channel blockers also inhibit delayed-rectifier K(+) currents in cardiac tissues and myocytes. However, estimated IC(50) values range over two to three orders of concentration, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c61d937fe0e37e4f42ff0900aec06966
https://pubmed.ncbi.nlm.nih.gov/11139462
https://pubmed.ncbi.nlm.nih.gov/11139462
Publikováno v:
British journal of pharmacology. 131(2)
1. The cardiac electrophysiological effects of S-oxybutynin, a single-enantiomer drug under evaluation for the management of urinary incontinence, have been investigated and compared with those of terodiline, an incontinence agent withdrawn following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44ae5f02c2e788a4e175e86d59288349
https://pubmed.ncbi.nlm.nih.gov/10991917
https://pubmed.ncbi.nlm.nih.gov/10991917
Autor:
L M, Shuba, T F, McDonald
Publikováno v:
Canadian journal of physiology and pharmacology. 78(8)
The objective of this study was to determine the effects of anion replacement on volume-sensitive anion current in guinea-pig ventricular myocytes. Myocytes in the conventional whole-cell voltage-clamp configuration were superfused and dialysed with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0a023b9cec2d7d4bf84a8b4419a75aa
https://pubmed.ncbi.nlm.nih.gov/10958168
https://pubmed.ncbi.nlm.nih.gov/10958168
Publikováno v:
Canadian journal of physiology and pharmacology. 77(5)
When guinea-pig papillary muscles were depolarized to ca. -30 mV by superfusion with K+-free Tyrode's solution supplemented with Ba2+, Ni2+, and D600, addition of Cs+ transiently hyperpolarized the membrane in a reproducible manner. The size of the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb007bda776830d6728469b716f48384
https://pubmed.ncbi.nlm.nih.gov/10535683
https://pubmed.ncbi.nlm.nih.gov/10535683
Publikováno v:
British journal of pharmacology. 127(8)
1. Terodiline, an anticholinergic/antispasmodic drug effective in the treatment of urinary incontinence, is presently restricted due to adverse side effects on cardiac function. To characterize its effects on cardiac L-type Ca2+-channel current carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1de1fa7a2e520e2a2a87aee2847d3ce
https://pubmed.ncbi.nlm.nih.gov/10482914
https://pubmed.ncbi.nlm.nih.gov/10482914
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
Terodiline was widely prescribed for urinary incontinence before reports of adverse cardiac effects that included bradycardia, QT lengthening, and ventricular tachyarrhythmia. The present study on guinea pig papillary muscles and ventricular myocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1dcb48d27a5bd5e7fbcb6fb92646bda
https://pubmed.ncbi.nlm.nih.gov/10454521
https://pubmed.ncbi.nlm.nih.gov/10454521
Publikováno v:
The Canadian journal of cardiology. 14(2)
To identify factors involved in the modification of cardiac electromechanical activity caused by hyperosmotic solution.Membrane potentials and contractions were recorded from isolated papillary muscles, and membrane ionic currents were measured in is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fba5bdfae1a22d707bff585ee57757ae
https://pubmed.ncbi.nlm.nih.gov/9520866
https://pubmed.ncbi.nlm.nih.gov/9520866