Výsledky vyhledávání - "T F, Holzman"

Variants in Apaf-1 segregating with major depression promote apoptosome function

Publikováno v: Molecular Psychiatry. 11:76-85

APAF1, encoding the protein apoptosis protease activating factor 1 (Apaf-1), has recently been established as a chromosome 12 gene conferring predisposition to major depression in humans. The molecular phenotypes of Apaf-1 variants were determined by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cdb96eb53759ad9f4298dca069dd527
https://doi.org/10.1038/sj.mp.4001755

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Preparation and characterization of nitrilotriacetic-acid-terminated self-assembled monolayers on gold surfaces for matrix-assisted laser desorption ionization-time of flight-mass spectrometry analysis of proteins and peptides

Autor: Andrew Vogt, Richard S. Smith, T. F. Holzman, Jianwei Shen, Robert E. Johnson, Jieyi Wang, John E. Harlan, Tanveer F. Ahmed, Sally Dorwin, Jean M. Severin

Publikováno v: Analytical Biochemistry. 345:258-269

On-target affinity capture, enrichment and purification of biomolecules improve detection of specific analytes from complex biological samples in matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) analysis. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2de9d5915d56f0913cf3974a412382
https://doi.org/10.1016/j.ab.2005.07.009

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Stromelysin Inhibitors Designed from Weakly Bound Fragments: Effects of Linking and Cooperativity

Autor: T. F. Holzman, Edward T. Olejniczak, Stephen W. Fesik, Rohinton Edalji, David G. Nettesheim, P. J. Hajduk, R. P. Meadows, P. A. Marcotte

Publikováno v: Journal of the American Chemical Society. 119:5828-5832

In the preceding paper,1 we reported on the discovery of potent, nonpeptide inhibitors of the matrix metalloproteinase stromelysin that were prepared by linking two ligands which bind weakly to adj...

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https://doi.org/10.1021/ja9702780

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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Autor: E. Gubbins, D. W. Morgan, Edward T. Olejniczak, Jean M. Severin, S. K. Davidsen, G. Sheppard, G. M. Carrera, Robert L. Simmer, D. H. Steinman, David G. Nettesheim, R. P. Meadows, T. F. Holzman, and J. B. Summers, H. Smith, P. A. Marcotte, Suzanne B. Shuker, Philip J. Hajduk, Karl A. Walter, Stephen W. Fesik

Publikováno v: Journal of the American Chemical Society. 119:5818-5827

With the use of an NMR-based method, potent (IC50 < 25 nM) nonpeptide inhibitors of the matrix metalloproteinase stromelysin (MMP-3) were discovered. The method, called SAR by NMR (for structure−activity relationships by nuclear magnetic resonance)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08e458e8b044870f08d7fbd35c1a163e
https://doi.org/10.1021/ja9702778

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Substrate requirements for ErmC' methyltransferase activity

Autor: K. A. Walter, R. P. Edalji, S. D. Pratt, Leonard Katz, Annapur Gurulingappa Shivakumar, T. F. Holzman, Ping Zhong

Publikováno v: Journal of Bacteriology. 177:4327-4332

ErmC' is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at a specific adenine residue (A-2085 in Bacillus subtilis; A-2058 in Escherichia coli).

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https://doi.org/10.1128/jb.177.15.4327-4332.1995

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?/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells

Autor: W.S. Wade, Mary P. Lambert, Seth W. Snyder, Gary T. Wang, Grant A. Krafft, Shasta L. Sabo, K. Barber, William L. Klein, T. F. Holzman, G. Stevens

Publikováno v: Journal of Neuroscience Research. 39:377-385

beta/A4 peptides are known to induce neurodegeneration in cultures of rat brain cells and rat neural cell lines (Yankner et al: Science 250:279-282, 1990; Behl et al: Biochem Biophys Res Commun 186:944-950, 1992). The current data show that these pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04aecc046ee471fd6b57a1734c1a0934
https://doi.org/10.1002/jnr.490390404

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Inhibitor stabilization of human immunodeficiency virus type-2 proteinase dimer formation

Autor: T F Holzman, J Erickson, D Kempf, D Weigl, William E. Kohlbrenner, Judith Rittenhouse

Publikováno v: Journal of Biological Chemistry. 266:19217-19220

We report the first direct observation of the subunit self-association behavior of highly purified recombinant human immunodeficiency virus type-2 (HIV-2) proteinase. Multiple samples of enzyme were subjected to sedimentation equilibrium analytical u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d111ca77e89594ad2094c791a93d906
https://doi.org/10.1016/s0021-9258(18)54985-1

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Protein fragmentation via liquid chromatography-quadrupole time-of-flight mass spectrometry: the use of limited sequence information in structural characterization

Autor: Tanveer F. Ahmed, Karl A. Walter, T. F. Holzman, Laura J. Miesbauer, Robert W. Johnson, John E. Harlan, Rohinton Edalji, Sarah A. Dorwin, Richard S. Smith

Publikováno v: Analytical biochemistry. 341(1)

Fragmentation and "top-down" sequencing of intact proteins by mass spectrometry (MS) is most commonly performed by infusion of protein solutions into Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. However, the high cost of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa6c57090500d59566ffc3d0c9ae346
https://pubmed.ncbi.nlm.nih.gov/15866524

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