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Akademický článek

Inhibition of cholesteryl ester transfer protein in normocholesterolemic and hypercholesterolemic hamsters: effects on HDL subspecies, quantity, and apolipoprotein distribution.

Autor: G F Evans, W R Bensch, L D Apelgren, D Bailey, R F Kauffman, T F Bumol, S H Zuckerman

Publikováno v: Journal of Lipid Research, Vol 35, Iss 9, Pp 1634-1645 (1994)

The effects of cholesteryl ester transfer protein (CETP) inhibition on the serum lipoprotein profile in both normocholesterolemic and hypercholesterolemic hamsters has been determined following subcutaneous injection of 12.5 mg/kg of the CETP neutral

Externí odkaz: https://doaj.org/article/8f11578b54454efeb82071934229f017

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Synthesis and Biological Evaluation of a New Series of Sterols as Potential Hypocholesterolemic Agents

Autor: Ashraff A. Rampersaud, Archer Ra, T F Bumol, Raymond F. Kauffman, L S Beavers, Ho-Shen Lin, Pawlak Jm, William R. Bensch, Schmidt Rj, L D Apelgren

Publikováno v: Journal of Medicinal Chemistry. 38:277-288

A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing the transcription of LDL receptor promoter in the presence of 25-hydroxycholesterol. The eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c7a660d1143ede3426f54cb972acc
https://doi.org/10.1021/jm00002a010

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Inhibition of cholesteryl ester transfer protein in normocholesterolemic and hypercholesterolemic hamsters: effects on HDL subspecies, quantity, and apolipoprotein distribution

Autor: W R Bensch, D. L. Bailey, T F Bumol, Glenn F. Evans, L D Apelgren, Steven H. Zuckerman, R F Kauffman

Publikováno v: Journal of Lipid Research, Vol 35, Iss 9, Pp 1634-1645 (1994)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c79f35867d3fabb839c56dbbdbf3d49
https://doi.org/10.1016/s0022-2275(20)41161-7

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Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979

Autor: A H, Dantzig, R L, Shepard, J, Cao, K L, Law, W J, Ehlhardt, T M, Baughman, T F, Bumol, J J, Starling

Publikováno v: Cancer research. 56(18)

Overexpression of P-glycoprotein (Pgp) by tumors results in multidrug resistance (MDR) to structurally unrelated oncolytics. MDR cells may be sensitized to these oncolytics when treated with a Pgp modulator. The present study evaluates LY335979 as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0aebe6542116121920b73ee25223acb8
https://pubmed.ncbi.nlm.nih.gov/8797588

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Long-term growth suppression of human glioma xenografts by chemoimmunoconjugates of 4-desacetylvinblastine-3-carboxyhydrazide and monoclonal antibody 9.2.27

Autor: M, Schrappe, T F, Bumol, L D, Apelgren, S L, Briggs, G A, Koppel, D D, Markowitz, B M, Mueller, R A, Reisfeld

Publikováno v: Cancer research. 52(14)

A conjugate of 4-desacetylvinblastine-3-carboxyhydrazide (DAVLBHY) and the glioma-reactive monoclonal antibody (mAb) 9.2.27 induced long-term suppression of tumor growth in athymic nude mice engrafted with U87MG human glioma cells. In vitro, DAVLBHY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c5a4268b29cd8556e8ce2804e0f385e
https://pubmed.ncbi.nlm.nih.gov/1617657

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The human immune response to KS1/4-desacetylvinblastine (LY256787) and KS1/4-desacetylvinblastine hydrazide (LY203728) in single and multiple dose clinical studies

Autor: B H, Petersen, S V, DeHerdt, D W, Schneck, T F, Bumol

Publikováno v: Cancer research. 51(9)

Monoclonal antibody (MoAb) conjugates have been used to treat a variety of malignancies. The majority of the MoAbs which have been used therapeutically are from murine sources. The infusion of these foreign proteins into humans can be expected to eli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db9e9c79150a007598395c231c48edbe
https://pubmed.ncbi.nlm.nih.gov/2015593

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In vivo selection of human tumor cells resistant to monoclonal antibody-Vinca alkaloid immunoconjugates

Autor: J J, Starling, R S, Maciak, N A, Hinson, J, Hoskins, B C, Laguzza, R A, Gadski, J, Strnad, L, Rittmann-Grauer, S V, DeHerdt, T F, Bumol

Publikováno v: Cancer research. 50(23)

UCLA-P3 human lung adenocarcinoma cells were grown in nude mice and given repetitive treatments of a monoclonal antibody-Vinca alkaloid immunoconjugate. Although this therapy resulted in a greater than 4-fold reduction in mean tumor mass of the estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::483884a7b612f747f01acc74b610db34
https://pubmed.ncbi.nlm.nih.gov/1979247

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Antitumor activity of the monoclonal antibody-Vinca alkaloid immunoconjugate LY203725 (KS1/4-4-desacetylvinblastine-3-carboxhydrazide) in a nude mouse model of human ovarian cancer

Autor: L D, Apelgren, D L, Zimmerman, S L, Briggs, T F, Bumol

Publikováno v: Cancer research. 50(12)

The activity of the conjugate of monoclonal antibody KS1/4 with 4-desacetylvinblastine-3-carboxhydrazide (KS1/4-DAVLB-HY) was explored in the OVCAR-3 human ovarian xenograft tumor model. Multiple schedules of KS1/4-DAVLB-HY administration were employ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2004a54c06fb732dadc97ba9900be746
https://pubmed.ncbi.nlm.nih.gov/2340502

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