Zobrazeno 1 - 9
of 9
pro vyhledávání: '"T E Maione"'
Publikováno v:
JNCI Journal of the National Cancer Institute. 82:848-853
Although it is well established that angiogenesis is essential to tumor development, no human protein with high specificity and efficacy for prevention of angiogenesis has been characterized. In a previous study, we demonstrated that recombinant plat
Publikováno v:
Anticancer research. 18(6A)
The present study was designed to test the hypothesis that rhPF4 binds with high specificity to the neovasculature of breast cancer carcinoma. To achieve this goal, we used intravital microscopy to study the binding characteristics of systemically in
Publikováno v:
The Journal of thoracic and cardiovascular surgery. 108(5)
The ability of recombinant platelet factor 4, a protein of human origin with high heparin affinity, and the present clinical heparin reversal agent, protamine, to neutralize heparin in human whole blood was studied by means of three standard whole bl
Publikováno v:
Thrombosis and haemostasis. 71(5)
Recombinant platelet factor 4 (rPF4) efficiently neutralized heparin anticoagulant activity in rats without the adverse effect of protamine sulfate (PS) (Circulation 1992; 85: 1102). This study confirmed that rPF4 and PS neutralized heparin in rats.
Publikováno v:
Cancer research. 51(8)
An analogue of human platelet factor 4 (PF4) lacking affinity for heparin was specifically designed to evaluate the importance of this property in the antitumor effects of recombinant PF4. The purified protein, recombinant PF4-241 (rPF4-241), failed
Publikováno v:
Anesthesiology. 81:A635
Publikováno v:
Anesthesiology. 77:A158
Publikováno v:
Anesthesiology. 77:A157
Publikováno v:
Archives of dermatology. 125(10)
Keratinocytes and endothelial cells produce basic fibroblast growth factor (b-FGF), and this cytokine is mitogenic for both cell types. Additionally, b-FGF is stored in the vicinity of keratinocytes and endothelial cells in basement membrane and extr