Zobrazeno 1 - 10
of 59
pro vyhledávání: '"T E Gaffney"'
Publikováno v:
Xenobiotica. 20:321-331
1. The objective of this study was to determine the oral dose pharmacokinetics and metabolism of 4'-methylthiopropranolol (MTP) in man and compare the results with observations for propranolol in previous studies. 2. Three women and five men received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1a789991bd15483b2d9bb3814769fa
https://doi.org/10.3109/00498259009046850
https://doi.org/10.3109/00498259009046850
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 253(1)
The effects of treatment with dl, d- or l-propranolol (subcutaneously for 1 week) on arterial blood pressure and on 6-keto prostaglandin (PG) F1 alpha (stable metabolite of PGI2) and PGE2 production by aorta, renal medulla and renal cortex were exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11f9fa84f7a6b02685c873ca409893c6
https://pubmed.ncbi.nlm.nih.gov/2109798
https://pubmed.ncbi.nlm.nih.gov/2109798
Publikováno v:
Clinical Pharmacology & Therapeutics. 26:548-554
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56df2ac48b7a8bdb4b0c7a5b94b4eda
https://doi.org/10.1002/cpt1979265548
https://doi.org/10.1002/cpt1979265548
Publikováno v:
The American Journal of Cardiology. 58:636-641
The effects of a standardized mixed meal, a self-selected meal and a sham meal on heart rate, arterial pressure, cardiac output, total systemic resistance and echocardiographic indexes of left ventricular performance were examined in normal volunteer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069a15563c23669a0fe72029ded58cda
https://doi.org/10.1016/0002-9149(86)90291-2
https://doi.org/10.1016/0002-9149(86)90291-2
Publikováno v:
Clinical Pharmacology and Therapeutics. 27:22-31
The disposition of the pharmacologically active 4-hydroxypropranolol (HO-P), its glucuronic acid conjugate (HO-P-G), and propranolol were compared after single intravenous and oral doses of propranolol in 6 normal subjects and after long-term therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e148d25f136eb3213319e02fa1d2d
https://doi.org/10.1038/clpt.1980.4
https://doi.org/10.1038/clpt.1980.4
Publikováno v:
Biochemical Pharmacology. 37:115-124
These studies have revealed that the delivery and actions of beta receptor antagonist drugs are controlled by a cascade of stereoselective processes involving multiple enzymes, transport proteins and receptors. In essence, the free concentration of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90c552f16b0e0dab4c1f7748405da57
https://doi.org/10.1016/0006-2952(88)90763-0
https://doi.org/10.1016/0006-2952(88)90763-0
Publikováno v:
British Journal of Pharmacology. 84:499-510
The accumulation and release of [3H]-propranolol and [3H]-atenolol were examined in synaptosomes from rat cerebral cortex. Synaptosomes accumulated 20 pmol propranolol and 0.6 pmol atenolol mg-1 protein when incubated at 30 degrees C with radiolabell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3767fd9ec49101532bc23572e4e3f51b
https://doi.org/10.1111/j.1476-5381.1985.tb12934.x
https://doi.org/10.1111/j.1476-5381.1985.tb12934.x
Autor:
Jerry G. Webb, Herman B. Daniell, T E Gaffney, L A Gourley, Thomas Walle, G A Hurwitz, S A Bai, C Boyd Loadholt
Publikováno v:
British Journal of Clinical Pharmacology. 16:599-608
Exercise-induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise-induced increments of 13 +/- 4% at 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fc6539e657232e56ffb79309da2d70
https://doi.org/10.1111/j.1365-2125.1983.tb02228.x
https://doi.org/10.1111/j.1365-2125.1983.tb02228.x
Publikováno v:
Clinical Pharmacology & Therapeutics. 24:668-677
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc991299e650d3014d1fdde8ad622489
https://doi.org/10.1002/cpt1978246668
https://doi.org/10.1002/cpt1978246668
Autor:
Edward C. Conradi, U. Kristina Walle, T E Gaffney, Mary-Joan Oexmann, Timothy C. Fagan, Thomas Walle
Publikováno v:
Clinical Pharmacology and Therapeutics. 30:790-795
The influence of a meal on the disposition and metabolism of oral propranolol was examined in six normal subjects. The meal induced a mean 53% increase in propranolol bioavailability (range 2% to 92%; P less than 0.01) without affecting time to maxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb5519c0a8eb37099d4dbdaed08796c
https://doi.org/10.1038/clpt.1981.239
https://doi.org/10.1038/clpt.1981.239