Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1‐Null Rat Hippocampus.

Autor: Wang, Yajie¹ (AUTHOR), Yang, Yuting¹ (AUTHOR), Cai, Ying¹ (AUTHOR), Aobulikasimu, Ayikaimaier¹ (AUTHOR), Wang, Yuexin¹ (AUTHOR), Hu, Chuanwei¹ (AUTHOR), Miao, Zhikang¹ (AUTHOR), Shao, Yue¹ (AUTHOR), Zhao, Mengna¹ (AUTHOR), Hu, Yue¹ (AUTHOR), Xu, Chang¹ (AUTHOR), Chen, Xinjun² (AUTHOR), Li, Zhiqiang² (AUTHOR), Chen, Jincao² (AUTHOR), Wang, Lianrong^1,3 (AUTHOR) lianrong2008@gmail.com, Chen, Shi^1,4 (AUTHOR) shichen@whu.edu.cn

Publikováno v: Advanced Science. 11/6/2024, Vol. 11 Issue 41, p1-18. 18p.

Microglia-Derived Vitamin D Binding Protein Mediates Synaptic Damage and Induces Depression by Binding to the Neuronal Receptor Megalin.

Autor: Kong Y; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China.; Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Zhang X; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China., Li L; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China., Zhao T; Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China., Huang Z; Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China., Zhang A; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China., Sun Y; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China., Jiao J; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China., Zhang G; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China., Liu M; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China.; Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China., Han Y; Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China., Yang L; Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China., Zhang Z; Department of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, 210096, China.; Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Dec 23, pp. e2410273. Date of Electronic Publication: 2024 Dec 23.

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin

Autor: J, Hilpert, H, Vorum, R, Burmeister, R, Spoelgen, I, Grishkovskaya, R, Misselwitz, A, Nykjaer, T E, Willnow

Publikováno v: The Biochemical journal. 360(Pt 3)

Sex hormone-binding globulin (SHBG) is the main carrier for androgens and oestrogens in humans. It mediates the transport of steroid hormones in the circulation and testicular fluid, and regulates their bioavailability to steroid-responsive tissues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a0e06c1a5dfb684c3429be0bb7ae4a7
https://pubmed.ncbi.nlm.nih.gov/11736650

Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors

Autor: T E, Willnow

Publikováno v: Biological chemistry. 379(8-9)

A number of cellular control mechanisms have evolved that facilitate and evaluate post-translational steps in protein biosynthesis. Chaperones or escort proteins are an important part of these cellular control mechanisms. They associate with newly sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b39bccb723cf22252cdc42b571a6682
https://pubmed.ncbi.nlm.nih.gov/9792434

Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts

Autor: E, Sehayek, X X, Wang, I, Vlodavsky, R, Avner, H, Levkovitz, T, Olivecrona, G, Olivecrona, T E, Willnow, J, Herz, S, Eisenberg

Publikováno v: Israel journal of medical sciences. 32(6)

Heparan sulfate and low density lipoprotein receptor related protein (LRP) have been shown to participate in the uptake and degradation of the enzyme lipoprotein lipase (LPL). Yet, the contribution of each of these pathways to LPL metabolism and thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25f131182d155e5b1378301de3a60672
https://pubmed.ncbi.nlm.nih.gov/8682650