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pro vyhledávání: '"T E, Wheldon"'
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Publikováno v:
Journal of Theoretical Biology. 210:93-100
A multistage mathematical model of tumorigenesis has been developed to explore the effects of target cell growth pattern on the proportions of tumours deriving from different tissues (the tumour spectrum). Analytical modelling techniques have shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aca3d179abc60cd557551478068754a
https://doi.org/10.1006/jtbi.2001.2300
https://doi.org/10.1006/jtbi.2001.2300
Autor:
T. E. Wheldon, Ann Barrett
Publikováno v:
Radiotherapy and Oncology. 58:227-233
Purpose : Total body irradiation (TBI) has been used as part of the conditioning regimen before bone marrow transplantation or stem cell re-infusion for more than 30 years. A wide variety of regimens have been used, and no single one has emerged as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b273d4b2a19498c7d71b9d6ab6ac28a4
https://doi.org/10.1016/s0167-8140(00)00255-3
https://doi.org/10.1016/s0167-8140(00)00255-3
Autor:
M. M. Brown, Anthony G. McCluskey, Robert J. Mairs, S. H. Cunningham, A. Livingstone, Sean Carlin, T. E. Wheldon, K. Stevenson, Marie Boyd, S. C. Mairs, L. Wilson
Publikováno v:
The Journal of Gene Medicine. 3:165-172
Background Although [I-131]meta-iodobenzylguanidine (MIBG) is currently one of the best agents available for targeted radiotherapy, its use is confined to a few neural crest derived tumours which accumulate the radiopharmaceutical via the noradrenali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a9889a5b7f5aa5d064fa961e3a964dd
https://doi.org/10.1002/1521-2254(2000)9999:9999<::aid-jgm158>3.0.co
https://doi.org/10.1002/1521-2254(2000)9999:9999<::aid-jgm158>3.0.co
Autor:
T. E. Wheldon
Publikováno v:
Physics in Medicine and Biology. 45:R77-R95
Radiation as a cancer treatment modality is of high physical precision but limited biological specificity. Targeted radiotherapy, the delivery of radiation to cancer cells by radioisotopes conjugated to tumour-seeking targeting agents, is a biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc3cee2ad053c8d6dff6174fc4a0bde
https://doi.org/10.1088/0031-9155/45/7/201
https://doi.org/10.1088/0031-9155/45/7/201
Autor:
Anthony G. McCluskey, Robert J. Mairs, S. H. Cunningham, A. Livingstone, Sean Carlin, T. E. Wheldon, M.M. Brown, Marie Boyd
Publikováno v:
Medical and Pediatric Oncology. 35:708-711
Background The aims of this study were to determine whether the introduction and expression of the noradrenaline transporter (NAT) gene into NAT-negative neuroblastoma cell lines would make them amenable to targeted radiotherapy using [131I]MIBG. Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6c4f8b104db756288bab4d427ea20d
https://doi.org/10.1002/1096-911x(20001201)35:6<708::aid-mpo49>3.0.co
https://doi.org/10.1002/1096-911x(20001201)35:6<708::aid-mpo49>3.0.co
Publikováno v:
International Journal of Radiation Biology. 76:963-969
Purpose : To seek the delayed appearance of chromosomal abnormalities in human fibroblasts exposed to the Auger electron emitter 125 I. Materials and methods : Normal untransformed human fibroblasts, HF19, were exposed to a concentration of [I 125 ]I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15432c2285c0f23a223884fe7143827
https://doi.org/10.1080/09553000050050972
https://doi.org/10.1080/09553000050050972
Publikováno v:
British Journal of Cancer
Childhood leukaemia presenting at a young age has been suspected of resulting from a leukaemogenic mutation in parental germ cells, either spontaneously or due to the exposure of a parent to leukaemogenic environmental hazards, particularly ionizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87f34769534f6c26d16c36f2b8a3207
http://europepmc.org/articles/PMC2362299
http://europepmc.org/articles/PMC2362299
Publikováno v:
Mathematical Biosciences. 139:1-24
A differential equation model is developed to represent a two-stage mutational process leading to childhood acute lymphoblastic leukemia (ALL). Leukemogenesis is modeled as transformation of target stem cells that initially grow rapidly in the embryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02934a1cc41349b5b19ea73b65723741
https://doi.org/10.1016/s0025-5564(96)00136-8
https://doi.org/10.1016/s0025-5564(96)00136-8
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
[131I]meta-iodobenzylguanidine ([131I]MIBG) provides a means of selectively delivering radiation to neuroblastoma cells and is a promising addition to the range of agents used to treat neuroblastoma. As MIBG is now being incorporated into multimodal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2568fb9973984bc0b2d2dc51fff884de
http://europepmc.org/articles/PMC2063308
http://europepmc.org/articles/PMC2063308