Výsledky vyhledávání - "T E, Sashenkova"

Regioselective Synthesis, Structure, and Chemosensitizing Antitumor Activity of Cyclic Hydroxamic Acid Based on DL-Valine

Autor: Alexander V. Chernyak, T. E. Sashenkova, E. N. Klimanova, D. V. Mishchenko, Yu. R. Aleksandrova, Margarita E. Neganova, I. V. Vystorop, Gennady V. Shilov, U. Yu. Allayarova, Sergey G. Klochkov

Publikováno v: Russian Journal of Bioorganic Chemistry. 47:757-764

The reaction of DL-valine hydroxamic acid with triacetonamine proceeds as the N,N'-regioselective condensation to form (±)-1-hydroxy-3-isopropyl-7,7,9,9-tetramethyl-1,4,8-triazaspiro[4,5]decan-2-one. A study of the antimetastatic and antitumor activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a09840a6f1a1250acfbe60c971bcfe7
https://doi.org/10.1134/s1068162021030171

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Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia

Autor: Sergey G. Klochkov, Margarita E. Neganova, Ghulam Md Ashraf, George E. Barreto, T. E. Sashenkova, Gjumrakch Aliev, Nagendra Sastry Yarla, E. N. Klimanova, Vadim V. Tarasov, I. V. Vystorop, Anna N. Samsonova, D. V. Mishchenko, Vladimir N. Chubarev, Elena F. Shevtsova

Publikováno v: Current Cancer Drug Targets. 18:365-371

Background: Anti-tumor effect of hydroxamic acid derivatives is largely connected with its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in carcinogenesis. Objective: The work was aimed to (i) determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c82e35e89ad52e1517593985c4da7f
https://doi.org/10.2174/1568009617666170623104030

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Sulfur-containing phenolic antioxidants increasing antitumor efficiency of cyclophosphamide and its combination with nitric oxide donor

Autor: N. V. Kandalintseva, T. E. Sashenkova, T. N. Bogatyrenko, D. V. Mishchenko

Publikováno v: Russian Chemical Bulletin. 67:700-704

Due to the multifactorial nature of cancer diseases, investigations of combinations of the known cytostatics with substances that are chemosensitizers and act on various molecular target in the organism gain increasing significance. Polyfunctional co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e23935370e8e50e1ddfe7bf817b1d6f
https://doi.org/10.1007/s11172-018-2125-4

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Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity

Autor: Nurgali Akylbekov, Julia K. Voronina, Anastasiya V. Gildebrant, T. E. Sashenkova, A. A. Balakina, Ugulzhan Allayarova, A. R. Burilov, Andrey V. Smolobochkin, I. S. Sazykin, Anastasia S. Sapunova, E. N. Klimanova, Elena Chugunova, D. V. Mishchenko, Alexandra D. Voloshina, Maria Klimova, Almir S. Gazizov, M. A. Sazykina, Shorena Karchava

Publikováno v: Molecules
Volume 24
Issue 17
Molecules, Vol 24, Iss 17, p 3086 (2019)

A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction of N-(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81cc7c2a8c7dde067db4cc1208e2330

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DL-valine cyclic hydroxamic acid: Synthesis and potential chemosensitizing antitumor action

Autor: I. V. Vistorop, D. V. Mishchenko, Margarita E. Neganova, T. E. Sashenkova, E. N. Klimanova

Publikováno v: AIP Conference Proceedings.

The reaction of DL-valine hydroxamic acid with triacetonamine passes as N, N′-regioselective cyclocondensation to form (±) -1-hydroxy-3-isopropyl-7,7,9,9-tetramethyl-1,4,8-triazaspiro [4.5] decan-2-one. In vivo study of chemosensitizing antitumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a58f9aace6809c4dfacdc3ddcf54991f
https://doi.org/10.1063/1.5087357

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Hydroxamic acids: synthesis and adjuvant activity in combinatorial anticancer therapy

Autor: D. V. Mishchenko, A. B. Eremeev, G. N. Bogdanov, L. V. Tat’yanenko, Fedorov Boris S, T. E. Sashenkova, Nina P. Konovalova, Mikhail A. Fadeev

Publikováno v: Russian Chemical Bulletin. 65:801-805

Monoand disubstituted N-hydroxyamides of dicarboxylic acids were prepared by reaction of dicarboxylic acids or acid anhydrides with hydroxylamine. The use of these compounds in combinatorial cytostatic therapy of implanted tumors with cisplatin or cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0144582eea6396f58590156876f6e40
https://doi.org/10.1007/s11172-016-1377-0

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The effect of ascorbic acid on the efficiency of cytotoxic therapy with cytostatic drugs in combination with NaNO3 and hydroxamic acids

Autor: T. E. Sashenkova, Nina P. Konovalova, V. R. Bogatyrenko, T. N. Bogatyrenko, Z. V. Kuropteva, D. V. Mishchenko, L. M. Bayder

Publikováno v: Russian Chemical Bulletin. 65:561-565

The present investigation is based on the paradoxical dichotomy of the biological action of nitric oxide (NO). Depending on its concentration in the organism, it can have therapeutic or pathogenic effect. It was shown that during the treatment with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c751593f19df1facfea9b628ea142b56
https://doi.org/10.1007/s11172-016-1337-8

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Polyfunctional action of biologically active compounds in antitumor chemotherapy of cyclophosphamide

Autor: T. E. Sashenkova, Z. V. Kuropteva, A. M. Sipyagin, Nina P. Konovalova, V. R. Bogatyrenko, T. N. Bogatyrenko, L. M. Baider, Fedorov Boris S

Publikováno v: Russian Chemical Bulletin. 63:1187-1191

Combinations of the known cytostatic cyclophosphamide (cyclophosphan) with hydroxamic acids (asparagylhydroxamic and salicylhydroxamic), nitric oxide donor (sodium nitrate), and an original hybrid non-steroidal anti-inflammatory compound, viz., diclo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae55f0d5fbb3e71caec0fe75d5cb8b64
https://doi.org/10.1007/s11172-014-0570-2

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