Výsledky vyhledávání

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme

Autor: D R Fregeau, T E Roche, P A Davis, R Coppel, M E Gershwin

Publikováno v: The Journal of Immunology. 144:1671-1676

Antimitochondrial antibodies (AMA) are serologically characteristic of patients with PBC. Four Ag recognized by AMA have been recently identified, including protein X and the acyltransferases of three related multienzyme complexes: the pyruvate dehyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::959ea741640178935b6180d04da8623a
https://doi.org/10.4049/jimmunol.144.5.1671

Zobrazit plný text záznamu

Dynamics Of Aids Manifestation: A Mathematical Prediction

Autor: A.H. Nagpal, R. Sodhi, S. Laxminarayan, S. S. Sofer, T. E. Roche

Publikováno v: [1990] Proceedings of the Twelfth Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

One of the major issues in the study of AIDS is under- standing the manifestation and the progression of the dis- ease following HIV transmission. A simulation approach can be used in predicting the various stage from HIV infec- tion to AIDS. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9167011a8e52c24627e8ce2daffe840
https://doi.org/10.1109/iembs.1990.691701

Zobrazit plný text záznamu

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

Autor: T E, Roche, J C, Baker, X, Yan, Y, Hiromasa, X, Gong, T, Peng, J, Dong, A, Turkan, S A, Kasten

Publikováno v: Progress in nucleic acid research and molecular biology. 70

The mammalian pyruvate dehydrogenase complex (PDC) plays central and strategic roles in the control of the use of glucose-linked substrates as sources of oxidative energy or as precursors in the biosynthesis of fatty acids. The activity of this mitoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26fd471a608dd35715562f184f19ec23
https://pubmed.ncbi.nlm.nih.gov/11642366

Zobrazit plný text záznamu

Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions

Autor: K, Ono, G A, Radke, T E, Roche, M, Rahmatullah

Publikováno v: The Journal of biological chemistry. 268(35)

The binding of the pyruvate dehydrogenase (E1) component and the E1-specific kinase to the core-forming dihydrolipoyl acetyltransferase (E2) component facilitates a severalfold enhancement in the rate at which the kinase phosphorylate E1 (i.e. versus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5d095188ff11a7f28450b8e5250773b
https://pubmed.ncbi.nlm.nih.gov/8253731

Zobrazit plný text záznamu

Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase

Autor: M S, Ali, T E, Roche, M S, Patel

Publikováno v: The Journal of biological chemistry. 268(30)

Pyruvate dehydrogenase (E1), the first catalytic component of the bovine pyruvate dehydrogenase complex, is composed of two nonidentical subunits in a tetrameric alpha 2 beta 2 form. The sulfhydryl-specific reagent N-ethylmaleimide (NEM) was used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f0bdcdfe4b9674a77b9c68a1fa4451c
https://pubmed.ncbi.nlm.nih.gov/8226745

Zobrazit plný text záznamu

Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex

Autor: T, Wagenknecht, R, Grassucci, G A, Radke, T E, Roche

Publikováno v: The Journal of biological chemistry. 266(36)

Cryoelectron microscopy has been performed on frozen-hydrated pyruvate dehydrogenase complexes from bovine heart and kidney and on various subcomplexes consisting of the dihydrolipoyl transacetylase-based (E2) core and substoichiometric levels of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7b12b3037329913f7306abe18765d9d
https://pubmed.ncbi.nlm.nih.gov/1761562

Zobrazit plný text záznamu

Molecular biology and biochemistry of pyruvate dehydrogenase complexes

Autor: M S, Patel, T E, Roche

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 4(14)

In most organisms, the pyruvate dehydrogenase complex catalyzes the pivotal irreversible reaction that leads to the consumption of glucose in the aerobic, energy-generating pathways. A combination of biochemical and molecular biology studies have gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91659d6c3b79ea0d47323ee080ceadf3
https://pubmed.ncbi.nlm.nih.gov/2227213

Zobrazit plný text záznamu

Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component

Autor: M, Rahmatullah, G A, Radke, P C, Andrews, T E, Roche

Publikováno v: The Journal of biological chemistry. 265(24)

The dihydrolipoyl transacetylase (E2) component contains a COOH-terminal inner domain (E2I) and an extended NH2-terminal structure, which is composed of two lipoyl domains (the fragment containing both is designated as E2L) and a subunit-binding doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47217804e9cb54e771fcadfd66dbb92f
https://pubmed.ncbi.nlm.nih.gov/2167319

Zobrazit plný text záznamu

Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme

Autor: D R, Fregeau, T E, Roche, P A, Davis, R, Coppel, M E, Gershwin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 144(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1970750acc381ee445a940d6ec66d31b
https://pubmed.ncbi.nlm.nih.gov/2106552

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání