Zobrazeno 1 - 6
of 6
pro vyhledávání: '"T E, Hedlund"'
Publikováno v:
Cancer research. 61(19)
1alpha, 25-Dihydroxyvitamin D(3) [1alpha, 25-(OH)(2)D(3)] is recognized to have significant antiproliferative effects on certain prostatic carcinoma (PC) cell lines, although the precise mechanisms of action remain in question. We have evaluated the
Publikováno v:
The Prostate. 41(3)
Many of the available human prostate cancer (PC) cell lines have lost androgen sensitivity and no longer secrete prostate-specific proteins after serial culturing in cell monolayers. Three-dimensional spheroid cultures have been found to better mimic
Publikováno v:
The Prostate. 36(2)
Apoptosis, or programmed cell death, can be mediated through an endogenous signaling pathway that emanates from a cell surface receptor known as Fas. Although best recognized for its role in the immune system, recent studies have also suggested a rol
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(8)
Numerous studies have indicated that the secosteroid hormone 1alpha, 25-dihydroxyvitamin D3 protects against the development of clinical prostate cancer (PC). Whether this hormone also has therapeutic potential for patients with advanced PC has not y
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(9)
Although prostatic cancer is often viewed as an androgen-dependent malignancy, a number of other hormones including 1alpha, 25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] are now recognized to modulate its growth and differentiated phenotype. Seven differ
Publikováno v:
Cancer research. 52(3)
The LNCaP prostatic carcinoma cell line was examined for the presence of specific receptors for 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)2D3]. Whole cell binding studies identified approximately 2500 high-affinity (Kd = 1.4 x 10(-9) binding sit