Zobrazeno 1 - 10 of 25 pro vyhledávání: '"T E, Hardingham"'
1
Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses
Autor: S L, Dunn, J, Soul, S, Anand, J-M, Schwartz, R P, Boot-Handford, T E, Hardingham
Publikováno v: Osteoarthritis and Cartilage
Summary Objectives Joint degeneration in osteoarthritis (OA) is characterised by damage and loss of articular cartilage. The pattern of loss is consistent with damage occurring only where the mechanical loading is high. We have investigated using RNA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55a5b9e2879dca37baa0b1e1c7ce179f
https://pubmed.ncbi.nlm.nih.gov/26973327
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4
Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies
Autor: W S, Khan, A B, Adesida, S R, Tew, U G, Longo, T E, Hardingham
Publikováno v: Cell proliferation. 45(2)
Background: Mesenchymal stem cells are able to undergo adipogenic differentiation and present a possible alternative cell source for regeneration and replacement of adipose tissue. The human infrapatellar fat pad is a promising source of mesenchymal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a561fae5758010f568c1b3664e71ec32
https://pubmed.ncbi.nlm.nih.gov/22260253
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5
Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis
Autor: J. J. Nietfeld, A. J. Duits, G. Venn, M. E. J. Billingham, Elizabeth C. Arner, T. E. Hardingham, F. M. Brennan, M. Covington
Publikováno v: Arthritis & Rheumatism. 36:819-826
Objective. To measure levels of cytokines, proteases, and glycosaminoglycans (GAG) in synovial fluid (SF) from the knees of animals with experimental osteoarthritis (OA) and from their contralateral (control) knees, and to compare and correlate these
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3fdb671dcaab53121080b6f7fe4cdd
https://doi.org/10.1002/art.1780360613
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6
The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain-chain association
Autor: P, Gribbon, B C, Heng, T E, Hardingham
Publikováno v: The Biochemical journal.
Confocal fluorescence recovery after photobleaching (confocal-FRAP) was used to examine the influence of electrolytes (NaCl, KCl, MgCl(2), MnCl(2) and CaCl(2)) on the network and hydrodynamic properties of fluoresceinamine-labelled hyaluronan (FA-HA)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9be93db0a2d600de084b01e5e02c8fce
https://pubmed.ncbi.nlm.nih.gov/10926861
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7
The structure of aggrecan and its turnover in cartilage
Autor: T E, Hardingham, A J, Fosang
Publikováno v: The Journal of rheumatology. Supplement. 43
Aggrecan is the major proteoglycan in cartilage. It has a multidomain structure with 3 globular and 2 extended segments. It forms large aggregates by binding to hyaluronan via the G1 domain, and link protein stabilizes the aggrecan-hyaluronan bond. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aae6ba0f336fe2b2990888c0cda8ff9e
https://pubmed.ncbi.nlm.nih.gov/7752148
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8
[Regulation of cartilage matrix synthesis by chondrocytes]
Autor: T E, Hardingham, V, Rayan, J C, Lewthwaite
Publikováno v: Revue du rhumatisme (Ed. francaise : 1993). 61(9 Pt 2)
Articular cartilage has important load bearing properties. These depend on the integrity of its matrix which is formed by a dense network of collagen fibres (mainly type II) and a high concentration of proteglycan (mainly aggrecan). The matrix is mai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fc5aea4a33080e403ff39bf361492fc
https://pubmed.ncbi.nlm.nih.gov/7858613
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9
The effect of recombinant human interleukin 1 receptor antagonist on the induction phase of antigen induced arthritis in the rabbit
Autor: J, Lewthwaite, S M, Blake, T E, Hardingham, P J, Warden, B, Henderson
Publikováno v: The Journal of rheumatology. 21(3)
To determine if systemic administration of human interleukin 1 receptor antagonist (IL-1ra) to rabbits during the induction phase of antigen induced arthritis (AIA) could block inflammation and cartilage proteoglycan loss.Recombinant human IL-1ra was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1c5f40a5e6584f8e82b665108e5fa16
https://pubmed.ncbi.nlm.nih.gov/8006890
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10
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B
Autor: A J, Fosang, P J, Neame, K, Last, T E, Hardingham, G, Murphy, J A, Hamilton
Publikováno v: The Journal of biological chemistry. 267(27)
The action of three matrix metalloproteinases (MMPs), 72- and 95-kDa gelatinases (MMP-2 and MMP-9) and PUMP (MMP-7), and a cysteine proteinase, cathepsin B, were investigated on aggrecan the major proteoglycan of cartilage. All the enzymes cleaved ag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c0e795846aa29b264f85afeee4ee62a
https://pubmed.ncbi.nlm.nih.gov/1326552
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