Výsledky vyhledávání - "T E, Cawston"

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels

Autor: S H Ridley, S J Sarsfield, J C Lee, H F Bigg, T E Cawston, D J Taylor, D L DeWitt, J Saklatvala

Publikováno v: The Journal of Immunology. 158:3165-3173

The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d5d1888a156c39a8d56bc9751a9ce97
https://doi.org/10.4049/jimmunol.158.7.3165

Zobrazit plný text záznamu

Proteinases and inhibitors

Autor: T E Cawston

Publikováno v: British Medical Bulletin. 51:385-401

The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases degrading collagen and proteoglycan. All four main classes of proteolytic enzymes are involved in either the normal turnover of connective tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8af7ca6e5d9534fddfe3c1df9b58d0c
https://doi.org/10.1093/oxfordjournals.bmb.a072968

Zobrazit plný text záznamu

Specificity of IgM antiglobulins produced in rheumatoid arthritis and tropical infections

Autor: T. E. Cawston, A. O. Adebajo, B. L. Hazleman

Publikováno v: Clinical Rheumatology. 14:37-40

The measurement of rheumatoid factors is of limited value in West Africa due to the low rheumatoid factor seroprevalence among patients with rheumatoid arthritis and the increased seroprevalence among healthy individuals and those with infectious dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f81b96edbab4c25f8c8a3ef144535f
https://doi.org/10.1007/bf02208082

Zobrazit plný text záznamu

THE SULPHATED GLYCOSAMINOGLYCAN LEVELS IN SYNOVIAL FLUID ASPIRATES IN PATIENTS WITH ACUTE AND CHRONIC JOINT DISEASE

Autor: T. E. Cawston, D. P. Page Thomas, J. T. Dingle, B. Silverman, B. L. Hazleman

Publikováno v: Rheumatology. 29:340-344

Proteoglycan levels were measured in a series of synovial fluid samples from patients with acute and chronic joint diseases using a modified chemical dye binding method. Levels found in 50 miscellaneous inflammatory arthritis fluids (mean = 173.2 +/-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d591e1094ee679783de65434a169d5
https://doi.org/10.1093/rheumatology/29.5.340

Zobrazit plný text záznamu

The biology of integration of the anterior cruciate ligament

Autor: David J. Deehan, T. E. Cawston

Publikováno v: The Journal of bone and joint surgery. British volume. 87(7)

The anterior cruciate ligament (ACL) is a short, stout, intra-articular, extrasynovial structure which acts to control rotational movements and anterior translation of the femur upon the fixed tibia.[1][1] Rupture is a traumatic event, often as a con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b766e1ce3cee0869756e30eae2a976
https://pubmed.ncbi.nlm.nih.gov/15972898

Zobrazit plný text záznamu

Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism

Autor: J B, Catterall, S, Carrère, P J, Koshy, B A, Degnan, W D, Shingleton, C E, Brinckerhoff, J, Rutter, T E, Cawston, A D, Rowan

Publikováno v: Arthritis and rheumatism. 44(10)

To investigate the mechanism of interleukin-1alpha (IL-1alpha) and oncostatin M (OSM) synergistic regulation of matrix metalloproteinase 1 (MMP-1) in human chondrocytes.Using an immortalized human chondrocyte cell line (T/C28a4), we investigated regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1572c72223ddf859d11deac71dbc89d
https://pubmed.ncbi.nlm.nih.gov/11665970

Zobrazit plný text záznamu

Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways

Autor: J M, Milner, S F, Elliott, T E, Cawston

Publikováno v: Arthritis and rheumatism. 44(9)

Bovine and human cartilages in explant culture respond to proinflammatory cytokines with the up-regulation of procollagenases. In stimulated bovine nasal cartilage (BNC),90% of collagen is released by day 14 of culture, but collagen release is rarely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd8220b78dbd85a0b734b8fa5579e13d
https://pubmed.ncbi.nlm.nih.gov/11592371

Zobrazit plný text záznamu

Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown

Autor: A D, Rowan, P J, Koshy, W D, Shingleton, B A, Degnan, J K, Heath, A B, Vernallis, J R, Spaull, P F, Life, K, Hudson, T E, Cawston

Publikováno v: Arthritis and rheumatism. 44(7)

To determine whether other glycoprotein 130 (gp130) binding cytokines can mimic the effects of oncostatin M (OSM) in acting synergistically with interleukin-1alpha (IL-1alpha) to induce cartilage collagen breakdown and collagenase expression, and to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5eecae77f2c1c2de274098e25f8612d
https://pubmed.ncbi.nlm.nih.gov/11465713

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání