Zobrazeno 1 - 10
of 24
pro vyhledávání: '"T Drexler"'
Publikováno v:
In Journal of the Mechanical Behavior of Biomedical Materials December 2020 112
Publikováno v:
The Glasgow Naturalist. 27:19-27
Small mammal trapping is a commonly taught field technique in ecology and population biology. However, there are still open questions regarding the extent to which trapping affects the welfare of small animals. This study investigated faecal cortisol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c244fa3cc727827079f9c6fcb0afabe
https://doi.org/10.37208/tgn27316
https://doi.org/10.37208/tgn27316
Akademický článek
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Publikováno v:
Nature Communications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::3d21b8aa46a9180ebbde5f403ee6bcb5
Publikováno v:
Organic Process Research & Development. 19:1119-1127
This study centers on the use of in situ FTIR spectroscopy and online NMR to study the nucleophilic addition of benzimidazole analogues to an N-methylpyridinium salt. The reaction consists of two stages. First, the protected benzimidazole was lithiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576b5f5af9c39c6e01ebf9b32c4991da
https://doi.org/10.1021/acs.oprd.5b00029
https://doi.org/10.1021/acs.oprd.5b00029
Autor:
R. Matt Weekly, Zhihui Peng, Hahdi H. Perfect, Teresa W. Makowski, Jade D. Nelson, Eric C. Hansen, Michele T. Drexler, David Place, Pascal Dube, Mark Olivier, Paul Bowles, Jason Mustakis, Nga M. Do, Stephane Caron, John J. Salisbury, John A. Ragan, Kris N. Jones, Tomislav A. Ljubicic, Shengquan Duan, Corey L. Stanchina, Brian P. Jones, Steven J. Brenek, Brian C. Vanderplas, Mark E. Webster
Publikováno v:
Organic Process Research & Development. 18:66-81
A practical synthesis of SGLT2 inhibitor candidate ertugliflozin (1) has been developed for potential commercial application. The highly telescoped process involves only three intermediate isolations over a 12-step sequence. The dioxa-bicyclo[3.2.1]o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c15ce612c3730496c6e393c8588d79
https://doi.org/10.1021/op4002802
https://doi.org/10.1021/op4002802
Autor:
Esmort Chisowa, Jade D. Nelson, Neil Choi, Zinka Brkic, Marcia A.-P. Lee, Brian P. Jones, Mark Olivier, Steven J. Brenek, Joe Desneves, Handfield Robert Eugene, Wayne Pearce, Michele T. Drexler, Jessica K. Watson, Stephane Caron, R. Matt Weekly, Mark P. Delude, G. C. A. Bellinger, Durgesh V. Nadkarni, Roberto Colon-Cruz
Publikováno v:
Organic Process Research & Development. 16:1338-1347
The research, development, and scale-up of the broad-spectrum antibacterial candidate sulopenem are presented. An enabled medicinal chemistry synthesis of this active pharmaceutical ingredient was utilized for Phase 1 and early Phase 2 manufacture bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef1cfea167cd3d8cbb3a8f3f3c3b3e5
https://doi.org/10.1021/op300130p
https://doi.org/10.1021/op300130p
Autor:
Jade D. Nelson, Handfield Robert Eugene, Nathan D. Ide, Hahdi H. Perfect, Esmort Chisowa, Mark P. Delude, Marcus Ewing, Durgesh V. Nadkarni, R. Matt Weekly, Mark Olivier, John J. Teixeira, Steven J. Brenek, John P. Zelina, James E. Phillips, Michele T. Drexler, Stephane Caron
Publikováno v:
Organic Process Research & Development. 16:1348-1359
Previous synthetic processes for the preparation of sulopenem involved multistep linear sequences in which the chiral sulfoxide side chain was introduced early in the process. This contribution summarizes the development of a practical and convergent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27868eef6640fda5cc31ed01a3b68a74
https://doi.org/10.1021/op300131e
https://doi.org/10.1021/op300131e
Publikováno v:
Journal of Catalysis. 214:136-145
The effect of several solvents on the heterogeneous synthesis of flavanone from benzaldehyde and 2-hydroxyacetophenone over a solid MgO catalyst was examined experimentally through kinetic and FTIR spectroscopic studies. High-boiling-point solvents c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3930ff40236a328c15dc3e8fab237fe4
https://doi.org/10.1016/s0021-9517(02)00013-1
https://doi.org/10.1016/s0021-9517(02)00013-1
Publikováno v:
Catalysis Letters. 79:175-181
The synthesis of flavanone was studied over a magnesium oxide solid catalyst in a batch reactor. The reaction scheme consists of the Claisen–Schmidt condensation of 2'-hydroxyacetophenone with benzaldehyde towards the formation of a 2'-hydroxychalc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362144128dde70ec2fdf0f664e4951b1
https://doi.org/10.1023/a:1015320711566
https://doi.org/10.1023/a:1015320711566