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Akademický článek

TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet

Autor: Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson

Publikováno v: Cell Reports, Vol 43, Iss 1, Pp 113673- (2024)

Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2

Externí odkaz: https://doaj.org/article/bafc4693a1fb4df690f3a63ad1e180e7

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Akademický článek

Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

Autor: Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot

Externí odkaz: https://doaj.org/article/eb23a693600e41d29543c852619dfa62

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Akademický článek

Strategies to increase rural maternal utilization of skilled health personnel for childbirth delivery in low- and middle-income countries: a narrative review

Autor: Jeanette R. Nelson, Rebekah H. Ess, Ty T. Dickerson, Lisa H. Gren, L. Scott Benson, Stephen O. Manortey, Stephen C. Alder

Publikováno v: Global Health Action, Vol 15, Iss 1 (2022)

Background Skilled attendance at birth is considered key to accomplishing Sustainable Development Goal (SDG) 3.1 aimed at reducing maternal mortality. Many maternal deaths can be prevented if a woman receives care by skilled health personnel. Materna

Externí odkaz: https://doaj.org/article/96888041a278415a93cbf46fcc10cac5

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Akademický článek

Using the Health Belief Model to explore rural maternal utilisation of skilled health personnel for childbirth delivery: a qualitative study in three districts of the Eastern Region of Ghana

Autor: Jeanette R Nelson, Lisa H Gren, Ty T Dickerson, L Scott Benson, Stephen O Manortey, Rebecca Ametepey, Yvette E Avorgbedor, Stephen C Alder

Publikováno v: Journal of Global Health Reports, Vol 5 (2021)

# Background Although maternal mortality has decreased substantially since the 1990s, it remains one of the top priorities in global health, as most deaths can be prevented if women have access to and utilise skilled health personnel for childbirth

Externí odkaz: https://doaj.org/article/05cd7735e75c45a09d10319cd9c501a7

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Akademický článek

A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young

Autor: Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Karolina E. Zaborska, Charles M. Schaub, Matthew A. Brown, David A. Jacobson, Emma L. Duncan

Publikováno v: JCI Insight, Vol 6, Iss 13 (2021)

Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] muta

Externí odkaz: https://doaj.org/article/33dbdc4478504d16946c60f7af11f097

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Akademický článek

Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry

Autor: Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson

Publikováno v: Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)

Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca

Externí odkaz: https://doaj.org/article/739b7a2b2b794efa9353527289b42407

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Akademický článek

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion

Autor: Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson

Publikováno v: Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)

Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r

Externí odkaz: https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf

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Elektronická kniha

Ents, Elves, and Eriador : The Environmental Vision of J.R.R. Tolkien

Autor: Matthew T. Dickerson, Jonathan Evans

Many readers drawn into the heroic tales of J. R. R. Tolkien's imaginary world of Middle-earth have given little conscious thought to the importance of the land itself in his stories or to the vital roles played by the flora and fauna of that land. A

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Akademický článek

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