Zobrazeno 1 - 10
of 54
pro vyhledávání: '"T Daniel Andrews"'
Autor:
Zuopeng Wu, Rong Liang, Thomas Ohnesorg, Vicky Cho, Wesley Lam, Walter P Abhayaratna, Paul A Gatenby, Chandima Perera, Yafei Zhang, Belinda Whittle, Andrew Sinclair, Christopher C Goodnow, Matthew Field, T Daniel Andrews, Matthew C Cook
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006067 (2016)
Most humans harbor both CD177neg and CD177pos neutrophils but 1-10% of people are CD177null, placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia. By
Externí odkaz:
https://doaj.org/article/6e78e15a6d4e4a64bb492e26851408cc
Autor:
Nazif Alic, T Daniel Andrews, Maria E Giannakou, Irene Papatheodorou, Cathy Slack, Matthew P Hoddinott, Helena M Cochemé, Eugene F Schuster, Janet M Thornton, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-17 (2011)
Abstract FoxO transcription factors, inhibited by insulin/insulin‐like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult f
Externí odkaz:
https://doaj.org/article/a19fe5b02a51451f857cd72f46fb2aa1
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143199 (2015)
A diversity of tools is available for identification of variants from genome sequence data. Given the current complexity of incorporating external software into a genome analysis infrastructure, a tendency exists to rely on the results from a single
Externí odkaz:
https://doaj.org/article/d9a9160d8d2d434d9de1370582bae9c0
Autor:
Nazif Alic, Maria E Giannakou, Irene Papatheodorou, Matthew P Hoddinott, T Daniel Andrews, Ekin Bolukbasi, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004619 (2014)
Forkhead box O (FoxO) transcription factors (TFs) are key drivers of complex transcriptional programmes that determine animal lifespan. FoxOs regulate a number of other TFs, but how these TFs in turn might mediate the anti-ageing programmes orchestra
Externí odkaz:
https://doaj.org/article/4a36148104c64ab9994ee0af9ad9b289
Autor:
Stephen R Daley, Kristen M Coakley, Daniel Y Hu, Katrina L Randall, Craig N Jenne, Andre Limnander, Darienne R Myers, Noelle K Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa A Miosge, Geoff Sjollema, Edward M Bertram, Matthew A Field, Yunli Shao, T Daniel Andrews, Belinda Whittle, S Whitney Barnes, John R Walker, Jason G Cyster, Christopher C Goodnow, Jeroen P Roose
Publikováno v:
eLife, Vol 2 (2013)
Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear aut
Externí odkaz:
https://doaj.org/article/99a34eaaa5914ca98a046571e4a1f72a
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000857 (2010)
Multicellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress resistance, reproduction, and
Externí odkaz:
https://doaj.org/article/180420ae8c7f4e87b8a707c483572543
Autor:
Juan Zhang, Donghong Yan, Christopher C. Goodnow, Wendy Sandoval, Jian Payandeh, Bettina L. Lee, Qingling Li, Vicky Cho, Irma B. Stowe, Zora Modrusan, Lisa A. Miosge, Min Xu, Rohit Reja, Gözde Ulas, Merone Roose-Girma, Jing Kang, T. Daniel Andrews, Opher S. Kornfeld, Vishva M. Dixit, Karen O'Rourke, Joshua D. Webster, Wyne P. Lee, Brent S. McKenzie, Meredith Sagolla, Nobuhiko Kayagaki, Lucy X. Morris, Edward M. Bertram
Publikováno v:
Nature. 591:131-136
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the inflammatory response1-3. The underlying mechanism of PMR,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd0fd5289574b697ae44372cb38c109
https://doi.org/10.1038/s41586-021-03218-7
https://doi.org/10.1038/s41586-021-03218-7
Autor:
Grant J. Brown, Pablo F. Cañete, Hao Wang, Arti Medhavy, Josiah Bones, Jonathan A. Roco, Yuke He, Yuting Qin, Jean Cappello, Julia I. Ellyard, Katharine Bassett, Qian Shen, Gaetan Burgio, Yaoyuan Zhang, Cynthia Turnbull, Xiangpeng Meng, Phil Wu, Eun Cho, Lisa A. Miosge, T. Daniel Andrews, Matt A. Field, Denis Tvorogov, Angel F. Lopez, Jeffrey J. Babon, Cristina Aparicio López, África Gónzalez-Murillo, Daniel Clemente Garulo, Virginia Pascual, Tess Levy, Eric J. Mallack, Daniel G. Calame, Timothy Lotze, James R. Lupski, Huihua Ding, Tomalika R. Ullah, Giles D. Walters, Mark E. Koina, Matthew C. Cook, Nan Shen, Carmen de Lucas Collantes, Ben Corry, Michael P. Gantier, Vicki Athanasopoulos, Carola G. Vinuesa
Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease1–7, evidence of lupus-causing TLR7 gene variants is lacking. Here we describe human systemic lupus erythem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c628d3582bbf90602398edce298d6d7f
https://hdl.handle.net/11541.2/31248
https://hdl.handle.net/11541.2/31248
Autor:
Aaron Chuah, Giles Walters, Daniel Christiadi, Krishna Karpe, Alice Kennard, Richard Singer, Girish Talaulikar, Wenbo Ge, Hanna Suominen, T. Daniel Andrews, Simon Jiang
Publikováno v:
Frontiers in medicine. 9
Background and ObjectivesChronic kidney disease progression to ESKD is associated with a marked increase in mortality and morbidity. Its progression is highly variable and difficult to predict.MethodsThis is an observational, retrospective, single-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff719f6e96928d61fe4c77ad6fb2f36
https://pubmed.ncbi.nlm.nih.gov/35372378
https://pubmed.ncbi.nlm.nih.gov/35372378
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2243
Increasingly affordable sequencing technologies are revolutionizing the field of genomic medicine. It is now feasible to interrogate all major classes of variation in an individual across the entire genome for less than $1000 USD. While the generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83a17dd66eae7a89b5a1694094a0f8ec
https://pubmed.ncbi.nlm.nih.gov/33606250
https://pubmed.ncbi.nlm.nih.gov/33606250