Zobrazeno 1 - 10
of 44
pro vyhledávání: '"T D McKinney"'
Autor:
T. D. McKinney, M. A. Hosford
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 263:G939-G946
Hepatocyte basolateral membrane possesses transport systems for mediated uptake of organic cations, the first step in the subsequent biliary excretion and/or metabolism of these compounds. The purpose of these studies was to evaluate potential mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd743967b1fd171407fdb00127aba484
https://doi.org/10.1152/ajpgi.1992.263.6.g939
https://doi.org/10.1152/ajpgi.1992.263.6.g939
Publikováno v:
Journal of Clinical Investigation. 90:211-218
The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na+/H+ exchange and basolateral Na+:HCO3- cotransport systems in metabolic acidosis. Proximal tubular suspensions were prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b765032a57dab30ba5772d60cbf43cad
https://doi.org/10.1172/jci115838
https://doi.org/10.1172/jci115838
Publikováno v:
Journal of the American Society of Nephrology. 2:1507-1515
In these studies, a clone of cells derived from the porcine renal epithelial line LLC-PK1 grown on porous filters was used to evaluate basolateral uptake of the organic cation tetraethylammonium (TEA). (3H) TEA (1 microM) entered cells in a saturable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fa443978aa291fb67561012759fac3
https://doi.org/10.1681/asn.v2101507
https://doi.org/10.1681/asn.v2101507
Autor:
T D, McKinney, M A, Hosford
Publikováno v:
The Journal of biological chemistry. 268(10)
These studies examined the ability of ATP to stimulate transport of the organic cation tetraethylammonium (TEA) into proximal tubular brush border membrane vesicles. ATP markedly enhanced TEA uptake for 1 h or more to values severalfold above those o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58a56ba09d43eeefea9d29af309c1e36
https://pubmed.ncbi.nlm.nih.gov/8463219
https://pubmed.ncbi.nlm.nih.gov/8463219
HCO3- exit across the basolateral membrane of the kidney proximal tubule cell is mediated via an electrogenic Na+:HCO3- cotransporter. In these experiments, we have studied the effect of internal pH on the activity of the Na+:HCO3- cotransport system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b2413f7ed64aa6652eacfe35206717
https://europepmc.org/articles/PMC295568/
https://europepmc.org/articles/PMC295568/
Publikováno v:
The Journal of biological chemistry. 266(9)
The effect of N-ethylmaleimide (NEM), an irreversible sulfhydryl modifying reagent, on the transport of organic cations in the renal basolateral membrane was examined. The studies were conducted examining the exchange of [3H]tetraethylammonium (TEA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1640e23bb1cfd62d41aba1fd91ae420e
https://pubmed.ncbi.nlm.nih.gov/2005090
https://pubmed.ncbi.nlm.nih.gov/2005090
Publikováno v:
Journal of the American Society of Nephrology : JASN. 1(6)
Mechanisms exist in renal proximal tubules for the mediated transepithelial secretion or reabsorption of endogenous and exogenous organic cations. In the studies presented here, the uptake of the organic cation tetraethylammonium (TEA) into confluent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b0c18c4d3cc91e1afb041b14e6e06b
https://pubmed.ncbi.nlm.nih.gov/2103849
https://pubmed.ncbi.nlm.nih.gov/2103849
Autor:
P. P. Sokol, T. D. McKinney
Publikováno v:
The American journal of physiology. 258(6 Pt 2)
The transports of [3H]tetraethylammonium (TEA), [3H]procainamide (PCA), and N1-[3H]methylnicotinamide (NMN) were studied in rabbit renal basolateral membrane vesicles (BLMVs) by use of a rapid filtration assay. All three compounds exhibited a similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a791889c7862adb22b6e81af5380e7e7
https://pubmed.ncbi.nlm.nih.gov/2141764
https://pubmed.ncbi.nlm.nih.gov/2141764
Autor:
T. D. McKinney, M. E. Kunnemann
Publikováno v:
American Journal of Physiology-Renal Physiology. 252:F525-F535
Cimetidine is an organic cation and commonly prescribed drug that is eliminated primarily by proximal renal tubular secretion. The present studies evaluated cimetidine transport in rabbit renal cortical brush-border membrane vesicles (BBMV). [3H]Cime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db47b7b674872155baf0df0150e6c931
https://doi.org/10.1152/ajprenal.1987.252.3.f525
https://doi.org/10.1152/ajprenal.1987.252.3.f525
Publikováno v:
American Journal of Physiology-Renal Physiology. 241:F69-F76
Cimetidine, a drug in widespread use in the treatment of peptic ulcer disease, is eliminated primarily via urinary excretion. We examined cimetidine transport by rabbit proximal straight tubules perfused in vitro. [3H]Cimetidine in the bath was activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec29810a6c568143f85a6e185df1fa05
https://doi.org/10.1152/ajprenal.1981.241.1.f69
https://doi.org/10.1152/ajprenal.1981.241.1.f69