Výsledky vyhledávání - "T D, Volkova"

Biologically Active Fragment of the Receptor for Advanced Glycation End Products (RAGE) Is Able to Inhibit Oligomerization of the Beta-Amyloid

Autor: T. D. Volkova, A. V. Avetisyan, D. O. Koroev, A. V. Kamynina, S. M. Balasanyants, R. A. Simonyan, O. M. Volpina

Publikováno v: Russian Journal of Bioorganic Chemistry. 48:731-738

Abstract It was found earlier that the synthetic fragment corresponding to the 60–76 sequence of the extracellular domain of the receptor for advanced glycation end products (RAGE) had a protective effect on animal and cellular models of Alzheimer�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::225d64c833e6cd095372314143c13f51
https://doi.org/10.1134/s1068162022040197

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Optimization of Solid-Phase Synthesis of the 1-40 Beta-Amyloid and Preparation of Antibodies Revealing It under Immunoblotting Conditions

Autor: T. D. Volkova, D. O. Koroev, A. V. Kamynina, A. V. Avetisyan, Olga M. Volpina, M. P. Filatova

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:217-222

The solid-phase synthesis and purification of the 1-40 sequence of the human beta-amyloid were optimized, resulting in a preparation of a product with a high yield and homogeneity more than 95%. The synthetic peptide is capable of forming oligomers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0ab6f0075f04e61c224e0fa1d7d724a
https://doi.org/10.1134/s1068162020020181

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Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer's disease models

Autor: T. D. Volkova, D. O. Koroev, Natalia V. Bobkova, Marina V. Serebryakova, A. V. Kamynina, Olga M. Volpina

Publikováno v: Drug development researchREFERENCES. 82(8)

The receptor for advanced glycation end products (RAGE) plays an essential role in Alzheimer's disease (AD). We previously demonstrated that a fragment (60-76) of RAGE improved the memory of olfactory bulbectomized (OBX) and Tg 5 × FAD mice - animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd021d46f91e4e0a9ff5d7a7efd2f34
https://pubmed.ncbi.nlm.nih.gov/34060112

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A synthetic fragment 60–70 of the receptor for advanced glycation end products exhibits a therapeutic effect in an animal model of Alzheimer’s disease

Autor: N. V. Bobkova, T. D. Volkova, A. V. Kamynina, D. O. Koroev, Olga M. Volpina, Samson M. Balasanyants, M. P. Filatova, A. N. Samokhin

Publikováno v: Russian Journal of Bioorganic Chemistry. 43:150-154

Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02751f82f59f78b2da625c6937eb784b
https://doi.org/10.1134/s1068162017020066

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Synthetic Fragment of Receptor for Advanced Glycation End Products Prevents Memory Loss and Protects Brain Neurons in Olfactory Bulbectomized Mice

Autor: A. V. Kamynina, N. I. Medvinskaya, Samson M. Balasanyants, T. D. Volkova, Tamara A. Voronina, A. N. Samokhin, Inna V. Nesterova, Olga M. Volpina, D. O. Koroev, Pavel V. Nekrasov, Olga G. Tatarnikova, Natalia V. Bobkova, A. M. Kulikov

Publikováno v: Journal of Alzheimer's disease : JAD. 61(3)

Activation of receptor for advanced glycation end products (RAGE) plays an essential role in the development of Alzheimer's disease (AD). It is known that the soluble isoform of the receptor binds to ligands and prevents negative effects of the recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175ccd2699facbb5a89746a3e54aa562
https://pubmed.ncbi.nlm.nih.gov/29332040

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A fragment of the receptor for advanced glycation end products restores the spatial memory of animals in a model of Alzheimer’s disease

Autor: N. V. Bobkova, D. O. Koroev, Ya. V. Zaporozhskaya, T. D. Volkova, A. V. Kamynina, A. N. Samokhin, M. P. Filatova, Olga M. Volpina, I. Yu. Aleksandrova

Publikováno v: Russian Journal of Bioorganic Chemistry. 41:638-644

The ability of some synthetic peptides modeling the potentially important regions of four membrane proteins, known as cell targets for beta-amyloid, to restore the spatial memory of animals in an experimental model of Alzheimer’s disease has been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1124205ac8fe4893a946efe83944773f
https://doi.org/10.1134/s1068162015060187

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Structure–Function mapping of the extracellular part of neurotrophin receptor P75

Autor: T. D. Volkova, N. I. Medvinskaya, A. N. Samokhin, Inna V. Nesterova, N. V. Bobkova, A. V. Kamynina, Olga M. Volpina, Ya. V. Zaporozhskaya, D. O. Koroev

Publikováno v: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 9:185-193

Receptor p75 is a classical membrane receptor, which consists of an extracellular region, a transmembrane region, and an intracellular C-terminus death domain. p75 is involved in the activation of neurotrophic factors and plays an essential role in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcae20d340e59be059967690f2e1ba45
https://doi.org/10.1134/s1990747815020142

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Protective activity of fragments of the prion protein after immunization of animals with experimentally induced Alzheimer’s disease

Autor: T. D. Volkova, Inna V. Nesterova, N. I. Medvinskaya, Ya. V. Zaporozhskaya, I. Yu. Aleksandrova, A. N. Samokhin, D. O. Koroev, V. I. Deygin, A. V. Kamynina, Olga M. Volpina, N. V. Bobkova

Publikováno v: Russian Journal of Bioorganic Chemistry. 41:125-132

The prion protein is considered as one of the membrane targets of the neurotoxic beta-amyloid during development of Alzheimer’s disease. We chose and synthesized peptide fragments that corresponded to the 17–33, 23–33, 95–110, and 101–115 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb6acf10db4e05296d6d367e7f29a2d3
https://doi.org/10.1134/s1068162015020168

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Preparation of antibodies capable of recognizing the Glu/Lys amino acid substitution at position 129 of the survivin sequence

Autor: T. D. Volkova, D. O. Koroev, E. V. Askarova, A. V. Kamynina, M. P. Filatova, I. Yu. Yakupov, Olga M. Volpina

Publikováno v: Russian Journal of Bioorganic Chemistry. 40:410-416

Survivin is an oncofetal protein involved in the inhibition of apoptosis and the regulation of cell division. The functions of survivin are determined by its structural state (monomer or dimer). Owing to the natural polymorphism, either the Glu or th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bca4427dcf6ea7b849d0a82dfb0320d2
https://doi.org/10.1134/s1068162014040141

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