Zobrazeno 1 - 6 of 6 pro vyhledávání: '"T D, Meek"'
1
Mechanism of inhibition of cathepsin K by potent, selective 1, 5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteases
Autor: M J, Bossard, T A, Tomaszek, M A, Levy, C F, Ijames, M J, Huddleston, J, Briand, S, Thompson, S, Halpert, D F, Veber, S A, Carr, T D, Meek, D G, Tew
Publikováno v: Biochemistry. 38(48)
The nature of the inhibition of thiol proteases by a new class of mechanism-based inhibitors, 1,5-diacylcarbohydrazides, is described. These potent, time-dependent, active-site spanning inhibitors include compounds that are selective for cathepsin K,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a6f7ece91586583a3481bd2f32db939
https://pubmed.ncbi.nlm.nih.gov/10625455
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2
Inhibitors of endothelin
Autor: M L, Webb, T D, Meek
Publikováno v: Medicinal research reviews. 17(1)
With the advent of the first generation of both selective and nonselective endothelin antagonists being a relatively recent event, the manifold therapeutic potentials of these compounds are only now being explored clinically. Undoubtedly, numerous cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b0e6bf5663127a671f7396ff3bab7b0
https://pubmed.ncbi.nlm.nih.gov/8979248
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3
Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere
Autor: S K, Thompson, K H, Murthy, B, Zhao, E, Winborne, D W, Green, S M, Fisher, R L, DesJarlais, T A, Tomaszek, T D, Meek, J G, Gleason
Publikováno v: Journal of medicinal chemistry. 37(19)
The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810ff4ecab5086a77f59bc6f9906ada9
https://pubmed.ncbi.nlm.nih.gov/7932533
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4
Use of steady state kinetic methods to elucidate the kinetic and chemical mechanisms of retroviral proteases
Autor: T D, Meek, E J, Rodriguez, T S, Angeles
Publikováno v: Methods in enzymology. 241
Despite the current plethora of structural data of HIV-1 protease and the availability of potent inhibitors, whose structures are based in part on the presumed mechanism of action of this enzyme, our actual understanding of its chemical mechanism has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49df213f6a991b9f20eccbd8e7181bc7
https://pubmed.ncbi.nlm.nih.gov/7854175
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