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Isoniazid Acetylation Phenotyping in the Japanese: The Molar Metabolic Ratio INH/AcINH

Autor: Haruichi Kohno, Atsushi Takada, Hiroaki Kubo, T. D. Arias, Masashi Mori

Publikováno v: American journal of therapeutics. 3(1)

The N-acetylation phenotyping of isoniazid (INH) was studied in 434 unrelated Japanese pulmonary tuberculosis patients. The frequency of slow acetylators was determined using three methods based on the urinary levels of INH and AcINH: percentage acet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adebfdf7bdaaad3e12251caca1604cd
https://pubmed.ncbi.nlm.nih.gov/11856999

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[Human biodiversity and its effects on the pharmacological variability: CYP2D6 and NAT2 enzymes in Amerind populations of Panama, Colombia and Costa Rica]

Autor: L F, Jorge, T D, Arias

Publikováno v: Revista medica de Panama. 20(3)

Human biodiversity originates partially from human microevolution, which have produced different populations. This biodiversity is responsible for most of the variability in drug response. We present the methodology employed in population pharmacolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5fefe05dd0b01d44efaadd3df6b24af
https://pubmed.ncbi.nlm.nih.gov/8668827

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['Cholos de Coclé': determination of their racial mixture and genetic origins]

Autor: T D, Arias, R, Barrantes, L F, Jorge, J, Azofeifa, M, Carles, R G, Cooke

Publikováno v: Revista medica de Panama. 17(3)

We have found, in this first genetic study of a supposedly admixed Panamanian population, that the cultural group known as "cholos of Coclé" constitute a trihybrid mixture, whose genetic pool has the following composition: 44% Amerindian, 38% Caucas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6da5b0b0306689c274f7e58fde93b10
https://pubmed.ncbi.nlm.nih.gov/1439003

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Uses and misuses of definitions of genetic polymorphism: A perspective from population pharmacogenetics

Autor: L F Jorge, Ramiro Barrantes, T D Arias

Publikováno v: British Journal of Clinical Pharmacology 31:117-119
Kérwá
Universidad de Costa Rica
instacron:UCR

carta al editor -- Universidad de Costa Rica. Instituto de Investigaciones en Salud. 1991 Definitions of genetic polymorphism currently employed in the pharmacological literature have been incorrectly used (Kalow, 1984) and uncritically imported from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f146e845e4143a6c80676eeccc8d7e86
Wiley Online Library

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[Population pharmacology and ethnopharmacokinetics in 3 Amerindian groups from Panama: Cuna, Ngawbe Guaymi and Teribe]

Autor: T D, Arias, L F, Jorge

Publikováno v: Revista medica de Panama. 15(1)

We report on studies of the oxidative routes associated with the polymorphic metabolism of debrisoquine, sparteine and mephenytoin, as well as on the pathway catalyzed by N-acetyl-transferase. Normal, healthy non-related subjects were studied: 250 Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c3854ddabfbad54a6ed92b94175eaeb
https://pubmed.ncbi.nlm.nih.gov/2330419

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Microevolution in lower Central America: genetic characterization of the Chibcha-speaking groups of Costa Rica and Panama, and a consensus taxonomy based on genetic and linguistic affinity

Autor: R, Barrantes, P E, Smouse, H W, Mohrenweiser, H, Gershowitz, J, Azofeifa, T D, Arias, J V, Neel

Publikováno v: American journal of human genetics. 46(1)

There is evidence that Amerindians have continuously occupied the lower Central American Isthmus for as long as 10,000 years. There remains some doubt about the relationships of these original colonizers to the resident peoples of this zone at the ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::362305f0cd98bedb5e4bcc444bdcafee
https://pubmed.ncbi.nlm.nih.gov/2294755

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On phenotyping with isoniazid: The use of urinary acetylation ratio and the uniqueness of antimodes. Study of two Amerindian populations

Autor: T D Arias, T Inaba

Publikováno v: Clinical Pharmacology and Therapeutics. 42:493-497

Various conventions have been used to express the activity of polymorphic hepatic N-acetyltransferase of isoniazid. Among them, two of the most common are the "percentage of acetylisoniazid" and the "inactivation index." A third alternative conventio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b06cb66a81ccc75a62a7f2d7a82ffcb
https://doi.org/10.1038/clpt.1987.186

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Alkaloid Screening of Panamanian Plants. I

Autor: A.A Soto, D. Acosta, E. Ferrabone, V. Turner, M. E. Restrepo, Mahabir P. Gupta, T. D. Arias, A. Rodrguez, R. Rivera, M. Correa

Publikováno v: Quarterly Journal of Crude Drug Research. 18:105-125

The Flora of Panama is one of the richest in the world (Schultes, 1972) as plants from South and Central America as well as from the Caribbean area can be found here. However, with the exception of research carried out by our group, the Panamanian pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bdea71c7bf76c917677c73bc0f20210
https://doi.org/10.3109/13880208009065187

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