Zobrazeno 1 - 10
of 123
pro vyhledávání: '"T C, Tai"'
Publikováno v:
Stresses, Vol 3, Iss 1, Pp 198-209 (2023)
For decades, the Barker hypothesis and thrifty phenotype hypothesis have driven researchers to explore the development of metabolic syndrome through fetal programming. In this short review, we provide peer-reviewed support for the fetal programming o
Externí odkaz:
https://doaj.org/article/2fcfb5ecc0654b46b3c69b9d28c636d9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Prenatal stress through glucocorticoid (GC) exposure leads to an increased risk of developing diseases such as cardiovascular disease, metabolic syndrome and hypertension in adulthood. We have previously shown that administration of the synt
Externí odkaz:
https://doaj.org/article/0c47c808289f4087a06a990c7099d406
Publikováno v:
Physiological Reports, Vol 10, Iss 9, Pp n/a-n/a (2022)
Abstract Adipose tissue (AT) has been found to exist in two predominant forms, white and brown. White adipose tissue (WAT) is the body's conventional storage organ, and brown adipose tissue (BAT) is responsible for non‐shivering thermogenesis which
Externí odkaz:
https://doaj.org/article/e139dedec2f4433694638299ac2c502b
Publikováno v:
Life, Vol 12, Iss 7, p 1077 (2022)
Fetal programming is the concept that maternal stressors during critical periods of fetal development can alter offspring phenotypes postnatally. Excess glucocorticoids can interact with the fetus to effect genetic and epigenetic changes implicated i
Externí odkaz:
https://doaj.org/article/548db1af432c42dbad93e957b02dbba5
Autor:
Christine Lalonde, Julie Grandbois, Sandhya Khurana, Alyssa Murray, Sujeenthar Tharmalingam, T. C. Tai
Publikováno v:
Brain and Behavior, Vol 11, Iss 4, Pp n/a-n/a (2021)
Abstract Introduction Fetal programming was characterized a few decades ago, explaining the correlation of physiological phenotypes of offspring exposed to early‐life stress. High acute or chronic prenatal stress can overwhelm the enzymatic placent
Externí odkaz:
https://doaj.org/article/e0686224563e4b10a6dcd487f87b0baa
Autor:
Alyssa Murray, Sujeenthar Tharmalingam, Sandhya Khurana, Christine Lalonde, Phong Nguyen, T. C. Tai
Publikováno v:
Cells, Vol 11, Iss 10, p 1613 (2022)
Circadian clocks control many vital aspects of physiology from the sleep-wake cycle to metabolism. The circadian clock operates through transcriptional-translational feedback loops. The normal circadian signaling relies on a ‘master clock’, locat
Externí odkaz:
https://doaj.org/article/55fa67a57ee94b2a9b86b5fa277749b8
Autor:
Jake Pirkkanen, Andrew M. Zarnke, Taylor Laframboise, Simon J. Lees, T. C. Tai, Douglas R. Boreham, Christopher Thome
Publikováno v:
Frontiers in Earth Science, Vol 8 (2020)
Biological research conducted in deep-underground environments is limited due to the lack of scientific infrastructure to accommodate the investigations, and only a few studies have utilized complex whole organism models. In this study, lake whitefis
Externí odkaz:
https://doaj.org/article/ba9404ed29444b8bbcac18e704390057
Autor:
Caitlund Q Davidson, Sujeenthar Tharmalingam, Sarah Niccoli, Ashley Nemec-Bakk, Sandhya Khurana, Alyssa Murray, T C Tai, Douglas R Boreham, Neelam Khaper, Simon J Lees
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231650 (2020)
Exposure to ionizing radiation contributing to negative health outcomes is a widespread concern. However, the impact of low dose and sub-lethal dose radiation (SLDR) exposures remain contentious, particularly in pregnant women who represent a vulnera
Externí odkaz:
https://doaj.org/article/cf846697228540c280a20a2e2d0e1e66
Autor:
Sandhya Khurana, Julie Grandbois, Sujeenthar Tharmalingam, Alyssa Murray, Kelly Graff, Phong Nguyen, T C Tai
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221719 (2019)
Biochemical changes in utero may alter normal fetal development, resulting in disease later in life, a phenomenon known as fetal programming. Recent epidemiological studies link fetal programming to negative health outcomes, such as low birth weight
Externí odkaz:
https://doaj.org/article/aaa99f4112f74045b5d0becef034aadb
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The immune system is increasingly recognized for its role in the genesis and progression of hypertension. The adrenal gland is a major site that coordinates the stress response via the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal s
Externí odkaz:
https://doaj.org/article/421420785c32415598ab95c197c6f661