Zobrazeno 1 - 10
of 12
pro vyhledávání: '"T C, Skaar"'
Autor:
L H, Cavallari, A L, Beitelshees, K V, Blake, L G, Dressler, J D, Duarte, A, Elsey, J N, Eichmeyer, P E, Empey, J P, Franciosi, J K, Hicks, A M, Holmes, Ljb, Jeng, C R, Lee, J J, Lima, N A, Limdi, J, Modlin, A O, Obeng, N, Petry, V M, Pratt, T C, Skaar, S, Tuteja, D, Voora, M, Wagner, K W, Weitzel, R A, Wilke, J F, Peterson, J A, Johnson
Publikováno v:
Clinical and Translational Science
Publikováno v:
Clinical and Translational Science
Autor:
Bert W. O'Malley, Faouzi Azzouz, CK Osborne, Daniel F. Hayes, Sean E. McGuire, Adrian V. Lee, A. S. Richter, J. Hayden, Ryan J. Hartmaier, T. C. Skaar, J. Z. Sallit, David A. Flockhart, PH Brown, Vered Stearns, Norah Lynn Henry, Steffi Oesterreich, Anne T. Nguyen, R. M. Gillihan, Santosh Philips, Jianming Xu, J. Wang, Lang Li, James M. Rae
Publikováno v:
Molecular Endocrinology. 26:220-227
The coregulator steroid receptor coactivator (SRC)-1 increases transcriptional activity of the estrogen receptor (ER) in a number of tissues including bone. Mice deficient in SRC-1 are osteopenic and display skeletal resistance to estrogen treatment.
Publikováno v:
Journal of Animal Science. 72:421-427
Insulin-like growth factors (IGF) are important growth regulators in many species, and their effects are influenced by their association with IGF-binding proteins (IGFBP). The objectives of this study were to characterize the ontogeny of the blood pl
Autor:
T. C. Skaar, Craig R. Baumrucker
Publikováno v:
Experimental Cell Research. 209:183-188
The regulation of insulin-like growth factor binding protein (IGFBP) secretion by mammogenic and lactogenic hormones was investigated in a mouse mammary epithelial cell line (COMMA-D/MME). Cells were grown to confluency on plastic culture plates in s
Publikováno v:
Pharmacological reviews. 53(1)
Antiestrogen therapy remains one of the most widely used and effective treatments for the management of endocrine responsive breast cancers. This reflects the ability of antiestrogens to compete with estrogens for binding to estrogen receptors. Where
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 7(12)
Nucleophosmin (NPM) is an estrogen-regulated nucleolar phosphoprotein; a substrate for phosphorylation by p34cdc2 kinase, protein kinase C, and casein kinase II; and a repressor of the transcriptional regulating activities of the YY1 and IFN regulato
Autor:
N, Brünner, B, Boysen, S, Jirus, T C, Skaar, C, Holst-Hansen, J, Lippman, T, Frandsen, M, Spang-Thomsen, S A, Fuqua, R, Clarke
Publikováno v:
Cancer research. 57(16)
Acquired resistance to antiestrogens is a major problem in the clinical management of initially endocrine responsive metastatic breast cancer. We have shown previously that estrogen-independent and -responsive MCF7/LCC1 human breast cancer cells sele
Publikováno v:
Journal of animal science. 72(2)
Insulin-like growth factors (IGF) are important growth regulators in many species, and their effects are influenced by their association with IGF-binding proteins (IGFBP). The objectives of this study were to characterize the ontogeny of the blood pl
Autor:
R. E. Aubert, E. J. Stanek, J. Yao, J. R. Teagarden, M. Subar, R. S. Epstein, T. C. Skaar, Z. Desta, D. A. Flockhart
Publikováno v:
Journal of Clinical Oncology. 27:CRA508-CRA508
CRA508 Background: Tamoxifen (TAM) is metabolized to its active form, endoxifen, by hepatic cytochrome P450 (CYP) 2D6. Diminished CYP2D6 function, both by genetic variation or concurrent use of pharmacologic inhibitors, can significantly reduce endox