Zobrazeno 1 - 10
of 20
pro vyhledávání: '"T C, Orton"'
Publikováno v:
Journal of biochemical and molecular toxicology. 14(2)
The molecular basis of how rodent nongenotoxic hepatocarcinogens such as phenobarbitone cause liver-tumor formation is poorly understood. An early effect of phenobarbitone exposure is to induce hepatocyte proliferation transiently, and there is evide
Publikováno v:
Carcinogenesis. 17(7)
The synthetic progestin cyproterone acetate (CPA) has been shown to be a hepatocarcinogen in the rat, but little is known of its effects in mice. A 52 week CPA study in the mouse strain C57Bl/10J has been reported not to produce liver tumours, althou
Publikováno v:
Carcinogenesis. 17(5)
Liver enlargement is a common feature of non-genotoxic rodent hepatocarcinogens administered at high doses. In the present study, the expression of growth factors and growth factor receptors was investigated in the C57BL/1OJ mouse during liver enlarg
Publikováno v:
Oncogene. 10(9)
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGFIIr) is required for the activation of transforming growth factor beta, and previously we have found its expression to be significantly reduced in both rat and human hepatocellula
Autor:
L A, Stanley, D R, Blackburn, S, Devereaux, J, Foley, P G, Lord, R R, Maronpot, T C, Orton, M W, Anderson
Publikováno v:
Carcinogenesis. 15(6)
The majority of genotoxic carcinogen-induced liver tumours of the sensitive B6C3F1 mouse contain activated H-ras oncogenes. Such mutations also occur in hepatocarcinogenesis-resistant strains. In order to determine whether this is true of non-genotox
Publikováno v:
Toxicologic pathology. 19(3)
The genotoxic carcinogen vinyl carbamate was dosed to C57Bl/10J strain mice for 35 weeks, and the study terminated after week 59. A main study group of 55 males and 50 females was dosed 6 mg/kg vinyl carbamate once weekly by intraperitoneal injection
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 194(3)
We have investigated the dynamics for the removal of 5-hydroxytryptamine (5-HT) from the circulation using the isolated perfused rabbit lung. 5-HT was removed from the circulation at a constant rate and metabolized completely to 5-hydroxyindoleacetic
Publikováno v:
British journal of pharmacology. 66(3)
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 234(2)
The disposition of [14C]practolol and its tissue association in the male Syrian hamster were investigated after p.o. administration. After an acute dose of 400 mg/kg, there was a marked persistence in the eye of total radioactivity (primarily practol
Publikováno v:
Journal of applied toxicology : JAT. 4(2)
An in vivo-in vitro test system with high sensitivity to teratogens has been developed and validated. A single acute intra-peritoneal injection of teratogens (18) and non-teratogens (13) was administered to pregnant rats on the 12th day after fertili