Zobrazeno 1 - 10
of 355
pro vyhledávání: '"T C, McMorris"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(9)
Acylfulvenes are a potent class of antitumor agents derived from illudin S, a fungal sesquiterpene. Illudin S possesses antitumor activity but has a poor therapeutic index. Acylfulvene is 100-fold less toxic against human lung adenocarcinoma cells th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::befcd21a7153b784b7fd566730be391a
https://pubmed.ncbi.nlm.nih.gov/10460795
https://pubmed.ncbi.nlm.nih.gov/10460795
Autor:
J R, MacDonald, C C, Muscoplat, D L, Dexter, G L, Mangold, S F, Chen, M J, Kelner, T C, McMorris, D D, Von Hoff
Publikováno v:
Cancer research. 57(2)
6-Hydroxymethylacylfulvene (HMAF; MGI 114) is a novel semisynthetic antitumor agent derived from the sesquiterpene mushroom toxin illudin S. In vitro cytotoxicity determinations produced IC50 concentrations (concentrations required for 50% inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90e57ed01b091f93088b5a3a3bbe9ab6
https://pubmed.ncbi.nlm.nih.gov/9000568
https://pubmed.ncbi.nlm.nih.gov/9000568
Autor:
M J, Kelner, T C, McMorris, L, Estes, R J, Starr, M, Rutherford, M, Montoya, K M, Samson, R, Taetle
Publikováno v:
Cancer research. 55(21)
Four second-generation Illudin analogues were synthesized and tested for antitumor activity using a metastatic lung carcinoma xenograft model resistant to conventional antitumor agents. One analogue, the parent illudofulvene-derivative called Acylful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e69fe4785b36395e586cee0cfc0ce36
https://pubmed.ncbi.nlm.nih.gov/7585533
https://pubmed.ncbi.nlm.nih.gov/7585533
Publikováno v:
Anticancer research. 15(3)
Six first-generation illudin analogs were tested for antitumor activity using in vitro cytotoxicity and in vivo xenograft models. One analog, dehydroilludin M, inhibited xenograft growth and prolonged life span of tumor bearing animals, when administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::020bb4ed1ff6e6781e0e0951b4b04592
https://pubmed.ncbi.nlm.nih.gov/7645974
https://pubmed.ncbi.nlm.nih.gov/7645974
Publikováno v:
Anticancer research. 15(3)
The human lung carcinoma cell line MV522 was previously noted to produce extensive metastasis to the lungs, spleen and lymph nodes after subcutaneous transplantation into athymic nude mice. Animals eventually succumb to these metastases, and not prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e452ad9ae2a9859b07b006be99c6c3b6
https://pubmed.ncbi.nlm.nih.gov/7645973
https://pubmed.ncbi.nlm.nih.gov/7645973
Autor:
M J, Kelner, T C, McMorris, L, Estes, M, Rutherford, M, Montoya, J, Goldstein, K, Samson, R, Starr, R, Taetle
Publikováno v:
Biochemical pharmacology. 48(2)
Illudins, novel natural products with a structure unrelated to any other known chemical, display potent in vitro and in vivo anti-cancer activity against even multi-drug resistant tumors, and are metabolically activated to an unstable intermediate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a98116e4d70ea31a20b63f5fec67fe2
https://pubmed.ncbi.nlm.nih.gov/8053936
https://pubmed.ncbi.nlm.nih.gov/8053936
Brassinosteroids promote stem elongation in a variety of plants but little is known about the mechanism of action of these plant growth regulators. We investigated a number of physiological and molecular parameters associated with brassinosteroid-enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104c0d5d69fb8c2b0a32ea759fa0050d
https://europepmc.org/articles/PMC159224/
https://europepmc.org/articles/PMC159224/
Publikováno v:
Neoplasma. 39(6)
High performance liquid chromatography (HPLC) combined with effective preseparation steps (liquid extraction, solid-phase extraction, preconcentration procedures) was used in pharmacokinetic studies of a novel anticancer agent (acylfulvene) in serum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c719b53b6e63a479ac29f4d0a4d32260
https://pubmed.ncbi.nlm.nih.gov/1491727
https://pubmed.ncbi.nlm.nih.gov/1491727
Publikováno v:
ACS Symposium Series ISBN: 9780841221260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df57302703fc94eb6404f57489296a5
https://doi.org/10.1021/bk-1991-0474.ch004
https://doi.org/10.1021/bk-1991-0474.ch004
Autor:
Le, Philipp1 (AUTHOR), Nodwell, Matthew B.1,2 (AUTHOR), Eirich, Jürgen1,3 (AUTHOR), Sieber, Stephan A.1 (AUTHOR) stephan.sieber@tum.de
Publikováno v:
Chemistry - A European Journal. 9/25/2019, Vol. 25 Issue 54, p12644-12651. 8p.