Zobrazeno 1 - 10
of 41
pro vyhledávání: '"T C, Elleman"'
Autor:
Colin W. Ward, T. C. Elleman, Morry J. Frenkel, Francesca Walker, Hong-Jian Zhu, Edouard C. Nice, George O. Lovrecz, Antony W. Burgess, Robert N. Jorissen, Thomas P. J. Garrett, Neil M. McKern, Timothy E. Adams, Meizhen Lou, Peter A. Hoyne
Publikováno v:
Cell. 110:763-773
We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts with both L1 and L2 domains of EGFR, making many main chain contacts with L1 and interacting with L2 via key conserved re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bbb4000c9c4df0d767dcc0bffb5b19
https://doi.org/10.1016/s0092-8674(02)00940-6
https://doi.org/10.1016/s0092-8674(02)00940-6
Autor:
T. C. Elleman, Peter A. Hoyne, John D. Bentley, Neil M. McKern, Leah J. Cosgrove, Colin W. Ward, Neva Ivancic
Publikováno v:
FEBS Letters. 479:15-18
Insulin receptors (IRs) that are truncated at the end of the ectodomain form dimers that bind insulin with different characteristics to wild type receptors. These soluble IRs have lowered affinity for insulin compared with full-length IR, and exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82da6c2b5a8360b2ab92dffc8849fb7b
https://doi.org/10.1016/s0014-5793(00)01872-x
https://doi.org/10.1016/s0014-5793(00)01872-x
Autor:
Kim Jachno, Leah J. Cosgrove, John D. Bentley, Colin W. Ward, M. J. Frenkel, Peter A. Hoyne, Neil M. McKern, Dean R. Hewish, T. C. Elleman, Sonia E. Sankovich
Publikováno v:
Biochemical Journal. 347:771-779
Site-directed mutagenesis has been used to remove 15 of the 18 potential N-linked glycosylation sites, in 16 combinations, from the human exon 11-minus receptor isoform. The three glycosylation sites not mutated were asparagine residues 25, 397 and 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29b779d8dd1107378579a82b521241b
https://doi.org/10.1042/bj3470771
https://doi.org/10.1042/bj3470771
Publikováno v:
FEBS Letters. 469:57-60
The insulin receptor (IR) and the insulin-like growth factor-I receptor (IGF-1R) show differential binding of insulin and IGFs. The specificity determinants for IGF-1 binding are known to be located in the cysteine-rich (Cys-rich) region between resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e653b9e0da2aca793968e4a72c1a04f7
https://doi.org/10.1016/s0014-5793(00)01237-0
https://doi.org/10.1016/s0014-5793(00)01237-0
Autor:
A.W.D. Lepper, J. R. Egerton, Jan M. Tennent, T. C. Elleman, C.L. Schwartzkoff, J.L. Atwell, Peter A. Hoyne, P.R. Lehrbach
Publikováno v:
Veterinary Microbiology. 36:175-183
Pili (fimbriae) were prepared from Moraxella bovis strain Dalton 2d (Dal2d) and from a derivative of Pseudomonas aeruginosa K/2PfS that contained a plasmid-borne Dal2d pilin gene and produced pili having serogroup-specific identity to Dal2d. Nine cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4183a82d34618ef69988574fc7f1882a
https://doi.org/10.1016/0378-1135(93)90138-w
https://doi.org/10.1016/0378-1135(93)90138-w
Publikováno v:
Infection and Immunity. 58:1678-1684
The pilin gene of Moraxella bovis Dalton 2d was isolated by cloning in Pseudomonas aeruginosa. The nucleotide sequence of this gene encodes a prepilin of 156 amino acid residues. When high levels of pilin were expressed from the gene in P. aeruginosa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564219e94b618570c62712682f39d9e1
https://doi.org/10.1128/iai.58.6.1678-1684.1990
https://doi.org/10.1128/iai.58.6.1678-1684.1990
Autor:
M. J. Frenkel, V. Chandana Epa, Timothy E. Adams, Elizabeth Da Silva, Peter A. Hoyne, John D. Bentley, Kellie Cartledge, Christine P. Robinson, Meizhen Lou, Colin W. Ward, Violet Stoichevska, T. C. Elleman, Neil M. McKern, George O. Lovrecz, Jennifer L. Lewis, Tam Pham, Ross Fernley, Sonia E. Sankovich, Michael C. Lawrence, Lindsay G. Sparrow, Victor A. Streltsov, Kim M. Richards, Patricia A. Pilling
Publikováno v:
Nature. 443(7108)
The first report of the crystal structure of the whole insulin receptor ectodomain dimer reveals how its multiple domains are organized. The structure also identifies the elusive second binding site on the receptor, and suggests how the high-affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414f6ec25fd18772716ee2d01329667c
https://pubmed.ncbi.nlm.nih.gov/16957736
https://pubmed.ncbi.nlm.nih.gov/16957736
Autor:
George O. Lovrecz, Edouard C. Nice, T. C. Elleman, Colin W. Ward, Timothy E. Adams, Thomas P. J. Garrett, Antony W. Burgess, Meizhen Lou, Robert N. Jorissen, Neil M. McKern, Michael Kofler
Publikováno v:
Molecular cell. 11(2)
ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8654709a0a1da987a41c67c76eee86c4
https://pubmed.ncbi.nlm.nih.gov/12620236
https://pubmed.ncbi.nlm.nih.gov/12620236
Autor:
Julie Rothacker, T. C. Elleman, Kim M. Richards, Peter A. Hoyne, Robert N. Jorissen, Jennifer Lewis, Thomas Peter John Garrett, Colin Wesley Ward, Geoffrey J. Howlett, Teresa Domagala, Edouard C. Nice, Antony W. Burgess, Timothy E. Adams, Meizhen Lou, Björn Lönnqvist, Maureen Nerrie, George O. Lovrecz, Neil M. McKern
Publikováno v:
Biochemistry. 40(30)
Murine and human epidermal growth factor receptors (EGFRs) bind human EGF (hEGF), mouse EGF (mEGF), and human transforming growth factor alpha (hTGF-alpha) with high affinity despite the significant differences in the amino acid sequences of the liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e297fe2f14501fa69c1ac316b1a7e99
https://pubmed.ncbi.nlm.nih.gov/11467954
https://pubmed.ncbi.nlm.nih.gov/11467954
Autor:
T C, Elleman, M J, Frenkel, P A, Hoyne, N M, McKern, L, Cosgrove, D R, Hewish, K M, Jachno, J D, Bentley, S E, Sankovich, C W, Ward
Publikováno v:
The Biochemical journal.
Site-directed mutagenesis has been used to remove 15 of the 18 potential N-linked glycosylation sites, in 16 combinations, from the human exon 11-minus receptor isoform. The three glycosylation sites not mutated were asparagine residues 25, 397 and 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bea3be7cf7628b6cb91e00ee6d9f67f
https://pubmed.ncbi.nlm.nih.gov/10769182
https://pubmed.ncbi.nlm.nih.gov/10769182