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Autor: M J, Smalley, T C, Dale

Publikováno v: Journal of mammary gland biology and neoplasia. 6(1)

Wnt expression patterns during mammary development support a role for Wnts in breast development and in mammary epithelial responses to systemic hormones. The deregulation of Wnt signaling also plays a role in breast cancer. Activation of the Wnt sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d15b833394ddf23978f4ac619777f13
https://pubmed.ncbi.nlm.nih.gov/11467451

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Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

Autor: R, Dajani, E, Fraser, S M, Roe, N, Young, V, Good, T C, Dale, L H, Pearl

Publikováno v: Cell. 105(6)

Glycogen synthase kinase 3 beta (GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. The crystal structure of human GSK3 beta sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a0eb7a9ad2a29cd8ef757fd3d144b6a
https://pubmed.ncbi.nlm.nih.gov/11440715

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Wnt signalling in mammalian development and cancer

Autor: M J, Smalley, T C, Dale

Publikováno v: Cancer metastasis reviews. 18(2)

Wnt signalling is involved in a variety of mammalian developmental processes, including cell proliferation, differentiation and epithelial-mesenchymal interactions, through which they contribute to the development of tissues and organs such as the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57a568c90d265dc5bfcbd9f4b114ca91
https://pubmed.ncbi.nlm.nih.gov/10728985

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