Zobrazeno 1 - 10
of 39
pro vyhledávání: '"T Burke-Wolin"'
Autor:
Susan C. Olson, Xinmei Li, Richard A. Oeckler, Frank Traganos, Litong Du, T. Burke-Wolin, Xiangmin Zhao
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L559-L568
We previously reported that angiotensin II stimulates an increase in nitric oxide production in pulmonary artery endothelial cells. The aims of this study were to determine which receptor subtype mediates the angiotensin II-dependent increase in nitr
Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells
Autor:
Nader G. Abraham, Alberto Nasjletti, Alvin I. Goodman, T. Burke-Wolin, Christopher J. Mingone, Liming Yang, Paul A. Mieyal, Michael S. Wolin, Shuo Quan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L1117-L1124
Carbon monoxide (CO) stimulates guanylate cyclase (GC) and increases guanosine 3′,5′-cyclic monophosphate (cGMP) levels. We transfected rat-lung pulmonary endothelial cells with a retrovirus-mediated human heme oxygenase (hHO)-1 gene. Pulmonary c
Publikováno v:
Respiration Physiology. 115:229-238
Observations that physiological levels of O2 control the rates of production of reactive O2 species by systems including NAD(P)H oxidases and that certain of these species have signalling mechanisms that regulate vascular tone has resulted in conside
Autor:
G. H. Gurtner, T. Burke-Wolin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 260:L207-L211
Oxidants have complex effects on pulmonary vascular reactivity. They can stimulate production of vasoconstrictor arachidonate mediators and can also cause vasodilation through activation of guanylate cyclase. Oxidants can also inactivate vasomotor ph
Publikováno v:
The American journal of physiology. 273(2 Pt 1)
Although angiotensin II (ANG II) is a known pulmonary vasoconstrictor, the purpose of this study was to examine the effect of ANG II on pulmonary artery endothelial cell nitric oxide synthase (ecNOS) mRNA and protein expression. Cultured bovine pulmo
Publikováno v:
The American journal of physiology. 273(1 Pt 1)
We have recently reported in normal isolated-perfused rat lungs that low basal tone appears to be regulated by nitric oxide (NO)-dependent and -independent mechanisms of soluble guanylate cyclase activation. In this study, we examined the role of NO
Publikováno v:
American journal of respiratory cell and molecular biology. 15(4)
Patients with systemic hypertension of various etiologies maintain their pulmonary artery pressures within normal limits. We have reported in isolated perfused rat lungs that low basal tone appears to be regulated by nitric oxide (NO)-dependent and -
Autor:
T. Burke-Wolin, J. A. Monaco
Publikováno v:
The American journal of physiology. 268(4 Pt 1)
Pulmonary hypoxic vasoconstriction appears to have both endothelium-dependent and -independent regulatory pathways. We have previously described a mechanism of guanylate cyclase activation in isolated pulmonary arteries that is smooth muscle containe
Publikováno v:
The American journal of physiology. 261(6 Pt 1)
Hydrogen peroxide (H2O2), but not tertbutyl hydroperoxide, produces a concentration-dependent vasodilation of the pulmonary circulation in isolated saline perfused rabbit lungs when pulmonary arterial pressures (PAP) are raised with the thromboxane a
Publikováno v:
Circulation research. 69(3)
Isolated bovine coronary arteries were treated with 10 mM diethyldithiocarbamate (DETCA) for 30 minutes to deplete the cytosolic ZnCu form of superoxide dismutase (SOD). This treatment completely inhibited the endothelium- and cGMP-dependent relaxati