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Autor:
S, Sarkar, K P, Jülicher, M S, Burger, V, Della Valle, C J, Larsen, T R, Yeager, T B, Grossman, R W, Nickells, C, Protzel, D F, Jarrard, C A, Reznikoff
Publikováno v:
Cancer research. 60(14)
Inactivation of both the pRb (pRb-cyclin D1/cyclin-dependent kinase 4/6-p16) and p53 (p53-p21(WAF1)-p14(ARF)) pathways is thought to be essential for immortalization in vitro and malignant transformation in vivo. We identified different combinations