Zobrazeno 1 - 10
of 508
pro vyhledávání: '"T Allain"'
Autor:
D Desmonts de Lamache, R Moges, A Siddiq, T Allain, T D Feener, G P Muench, N McKenna, R M Yates, A G Buret
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221560 (2019)
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-stranded RNA virus that grows in macrophages and causes acute pneumonia in pigs. PRRSV causes devastating losses to the porcine industry. However, due to its high antigenic var
Externí odkaz:
https://doaj.org/article/2b0d8859b92e4274a8917d16b91d1e46
Autor:
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut
Externí odkaz:
https://doaj.org/article/d8245675d28e4b2bbc482fdb79f08563
Autor:
Piotr Klukowski, Fred F. Damberger, Frédéric H.-T. Allain, Hideo Iwai, Harindranath Kadavath, Theresa A. Ramelot, Gaetano T. Montelione, Roland Riek, Peter Güntert
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Multidimensional NMR spectra are the basis for studying proteins by NMR spectroscopy and crucial for the development and evaluation of methods for biomolecular NMR data analysis. Nevertheless, in contrast to derived data such as chemical shi
Externí odkaz:
https://doaj.org/article/d607f976b6f94288a6a64321321d3e7a
Autor:
Ahmed Moursy, Antoine Cléry, Stefan Gerhardy, Katharina M. Betz, Sanjana Rao, Jarosław Mazur, Sébastien Campagne, Irene Beusch, Malgorzata M. Duszczyk, Mark D. Robinson, Vikram Govind Panse, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iC
Externí odkaz:
https://doaj.org/article/4a88fb1ca6af451d9d41da0376069163
Autor:
Anna Knörlein, Chris P. Sarnowski, Tebbe de Vries, Moritz Stoltz, Michael Götze, Ruedi Aebersold, Frédéric H.-T. Allain, Alexander Leitner, Jonathan Hall
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Although UV-induced cross-linking is a widely used method to study RNA-protein complexes, the cross-linking reactions are poorly understood. Here, the authors show that π-stacking interactions between nucleobases and aromatic amino acids play a key
Externí odkaz:
https://doaj.org/article/2cd6d485f0bf4ae2b1dfd7988cfbb5cd
Autor:
Antoine Cléry, Miroslav Krepl, Cristina K. X. Nguyen, Ahmed Moursy, Hadi Jorjani, Maria Katsantoni, Michal Okoniewski, Nitish Mittal, Mihaela Zavolan, Jiri Sponer, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
SRSF1 is an oncoprotein that plays important roles in RNA metabolism. We reveal the structure of the human SRSF1 RRM1 bound to RNA, and propose a bimodal mode of interaction of the protein with RNA. A single mutation in RRM1 changed SRSF1 specificity
Externí odkaz:
https://doaj.org/article/f3116688ba6245dbbc7d39591d69df23
Autor:
Daniel Jutzi, Sébastien Campagne, Ralf Schmidt, Stefan Reber, Jonas Mechtersheimer, Foivos Gypas, Christoph Schweingruber, Martino Colombo, Christine von Schroetter, Fionna E. Loughlin, Anny Devoy, Eva Hedlund, Mihaela Zavolan, Frédéric H.-T. Allain, Marc-David Ruepp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS). Here the authors characterize FUS-binding to U1 snRNP and show that ALS-associated FUS aberrantly contacts U1 snRNA which interferes with its biogenesis pathway.
Externí odkaz:
https://doaj.org/article/29a7f401a44547198252c6ea20fa553a
Autor:
Daniel Mayer, Fred F. Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock, Brian Bauer, Eshita Mutt, Franziska Zosel, Frédéric H. T. Allain, Jörg Standfuss, Gebhard F. X. Schertler, Xavier Deupi, Martha E. Sommer, Mattan Hurevich, Assaf Friedler, Dmitry B. Veprintsev
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C
Externí odkaz:
https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976b
Autor:
Giacomo Padroni, Maria Bikaki, Mihajlo Novakovic, Antje C. Wolter, Simon H. Rüdisser, Alvar D. Gossert, Alexander Leitner, Frederic H.-T Allain
Publikováno v:
Nucleic Acids Research, 51 (9)
The pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf60958a131b4e8fd2d201a1a1706843
https://doi.org/10.1093/nar/gkad195
https://doi.org/10.1093/nar/gkad195
Autor:
Thomas Wiegand, Denis Lacabanne, Anahit Torosyan, Julien Boudet, Riccardo Cadalbert, Frédéric H.-T. Allain, Beat H. Meier, Anja Böckmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Today, the sedimentation of proteins into a magic-angle spinning (MAS) rotor gives access to fast and reliable sample preparation for solid-state Nuclear Magnetic Resonance (NMR), and this has allowed for the investigation of a variety of non-crystal
Externí odkaz:
https://doaj.org/article/ac55a9986b3148cc9e409b2ba7bfa6cc