Zobrazeno 1 - 10
of 112
pro vyhledávání: '"T Alexander, Quinn"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
In the adult heart, acute adaptation of electrical and mechanical activity to changes in mechanical load occurs via feedback processes known as “mechano-electric coupling” and “mechano-mechanical coupling.” Whether this occurs during cardiac
Externí odkaz:
https://doaj.org/article/ac96dca868404c76992da6675c28be03
Autor:
Matthew R. Stoyek, Eilidh A. MacDonald, Melissa Mantifel, Jonathan S. Baillie, Bailey M. Selig, Roger P. Croll, Frank M. Smith, T. Alexander Quinn
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Cardiac excitation originates in the sinoatrial node (SAN), due to the automaticity of this distinct region of the heart. SAN automaticity is the result of a gradual depolarisation of the membrane potential in diastole, driven by a coupled system of
Externí odkaz:
https://doaj.org/article/e9ef0578676e48a39c4578966db61b36
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optogenetics, involving the optical measurement and manipulation of cellular activity with genetically encoded light-sensitive proteins (“reporters” and “actuators”), is a powerful experimental technique for probing (patho-)physiological func
Externí odkaz:
https://doaj.org/article/bfca15ba8c2c4411a1345b196c636867
Autor:
Eilidh A. MacDonald, Josef Madl, Joachim Greiner, Ahmed F. Ramadan, Sarah M. Wells, Angelo G. Torrente, Peter Kohl, Eva A. Rog-Zielinska, T. Alexander Quinn
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The rhythmic electrical activity of the heart’s natural pacemaker, the sinoatrial node (SAN), determines cardiac beating rate (BR). SAN electrical activity is tightly controlled by multiple factors, including tissue stretch, which may contribute to
Externí odkaz:
https://doaj.org/article/a223c688e90a4c52a6f06f0565159a4c
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Introduction: In ventricular myocytes, spontaneous release of calcium (Ca2+) from the sarcoplasmic reticulum via ryanodine receptors (“Ca2+ sparks”) is acutely increased by stretch, due to a stretch-induced increase of reactive oxygen species (RO
Externí odkaz:
https://doaj.org/article/fc1c2a7d08cd4719a1e0cea463ff6f5f
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the natural pacemaker of the heart, making it responsible for initiating each-and-every normal heartbeat. As such, its activity is heavily controlled, allowing
Externí odkaz:
https://doaj.org/article/2d32a8ac178f42c395b1507dc06cd313
Autor:
Crystal M. Ripplinger, Alexey V. Glukhov, Matthew W. Kay, Bastiaan J. Boukens, Nipavan Chiamvimonvat, Brian P. Delisle, Larissa Fabritz, Thomas J. Hund, Bjorn C. Knollmann, Na Li, Katherine T. Murray, Steven Poelzing, T. Alexander Quinn, Carol Ann Remme, Stacey L. Rentschler, Robert A. Rose, Nikki G. Posnack
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(6):H1137-H1166
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although recent advances in cell-based models, including human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM), are contributing to our understanding of electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f634ea199ebedbe0ad732ee2517bfaf2
https://doi.org/10.1152/ajpheart.00439.2022
https://doi.org/10.1152/ajpheart.00439.2022
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 11, p 149 (2021)
The intracardiac nervous system (IcNS), sometimes referred to as the “little brain” of the heart, is involved in modulating many aspects of cardiac physiology. In recent years our fundamental understanding of autonomic control of the heart has dr
Externí odkaz:
https://doaj.org/article/5235a03be618446f84ecaeced7fba84d
Autor:
Peter Baumeister, T. Alexander Quinn
Publikováno v:
Clinical Medicine Insights: Cardiology, Vol 2016, Iss Suppl. 1, Pp 61-69 (2016)
Externí odkaz:
https://doaj.org/article/ddeb07e2eae84b358772e164278db420
Autor:
Ramona A. Kopton, Jonathan S. Baillie, Sara A. Rafferty, Robin Moss, Callum M. Zgierski-Johnston, Sergey V. Prykhozhij, Matthew R. Stoyek, Frank M. Smith, Peter Kohl, T. Alexander Quinn, Franziska Schneider-Warme
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
During the last decade, optogenetics has emerged as a paradigm-shifting technique to monitor and steer the behavior of specific cell types in excitable tissues, including the heart. Activation of cation-conducting channelrhodopsins (ChR) leads to mem
Externí odkaz:
https://doaj.org/article/7aa61847c504434382bca44f3b3b283e