Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

Autor: Chandrika N. Deshpande, T. Alex Ruwe, Ali Shawki, Vicky Xin, Kyle R. Vieth, Erika V. Valore, Bo Qiao, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that

Externí odkaz: https://doaj.org/article/61dff6b0396e40ccba89522883e761ae

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Autor: Bo Qiao, Mika Jormakka, T Alex Ruwe, Sharraya Aschemeyer, Kyle R. Vieth, Tomas Ganz, Bryan Mackenzie, Deborah Stefanova, Albert C. Sek, Stefano Rivella, Erika V. Valore, Carla Casu, Elizabeta Nemeth, Grace Jung

Publikováno v: Blood. 131:899-910

Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal iron overload. Fpn is regulated by the hormone hepcidin, which induces Fpn endocytos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe457e05e36c922303764756b0ef709
https://doi.org/10.1182/blood-2017-05-786590

Ablation of Na + /H + exchanger‐3 prevents iron loading in the Hfe mouse model of hereditary hemochromatosis

Autor: Corbin R. Azucenas, John P. Bonamer, Bryan Mackenzie, Ali Shawki, T Alex Ruwe, Sydney L Stone

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92429751c6c4ff871d21872439dd3884
https://doi.org/10.1096/fasebj.2019.33.1_supplement.825.2

Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

Autor: Vicky Xin, T Alex Ruwe, Bryan Mackenzie, Kyle R. Vieth, Bo Qiao, Ali Shawki, Mika Jormakka, Chandrika N. Deshpande, Tomas Ganz, Erika V. Valore, Elizabeta Nemeth

Publikováno v: Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Deshpande, CN; Ruwe, TA; Shawki, A; Xin, V; Vieth, KR; Valore, EV; et al.(2018). Calcium is an essential cofactor for metal efflux by the ferroportin transporter family. NATURE COMMUNICATIONS, 9. doi: 10.1038/s41467-018-05446-4. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0wp7091s
Nature Communications

Ferroportin (Fpn)—the only known cellular iron exporter—transports dietary and recycled iron into the blood plasma, and transfers iron across the placenta. Despite its central role in iron metabolism, our molecular understanding of Fpn-mediated i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019374d32f398be01e118b12e65275cb
https://escholarship.org/uc/item/0wp7091s

Role of N ‐glycosylation in the activity of divalent metal‐ion transporter‐1

Autor: Kyle R. Vieth, Justin L. Dunham, Ali Shawki, François Canonne-Hergaux, T Alex Ruwe, Bryan Mackenzie

Publikováno v: The FASEB Journal. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::989d4a602bd1c0312f3bfde3fef0c775
https://doi.org/10.1096/fasebj.2018.32.1_supplement.876.1