Zobrazeno 1 - 10
of 44
pro vyhledávání: '"T A Leahy"'
Autor:
B. Molloy, E. R. Jones, N. D. Linhares, P. G. Buckley, T. R. Leahy, B. Lynch, I. Knerr, M. D. King, K. M. Gorman
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A uniparental disomy (UPD) screen using whole genome sequencing (WGS) data from 164 trios with rare disorders in the Irish population was performed to identify large runs of homozygosity of uniparental origin that may harbour deleterious recessive va
Externí odkaz:
https://doaj.org/article/3304b808fb3047b5b18067d57703b71e
Autor:
T. P. Leahy
Publikováno v:
Advances in Statistical Climatology, Meteorology and Oceanography, Vol 7, Pp 1-11 (2021)
Hurricanes are destructive forces of nature that have the ability to cause vast devastation both economically and socially. Estimating the potential damage caused by hurricanes aids local, state and federal governments as well as insurance and reinsu
Externí odkaz:
https://doaj.org/article/d5da7564cc0541929f6407891cc7a30d
Autor:
Jérôme Hadjadj, Carla Noemi Castro, Maud Tusseau, Marie-Claude Stolzenberg, Fabienne Mazerolles, Nathalie Aladjidi, Martin Armstrong, Houman Ashrafian, Ioana Cutcutache, Georg Ebetsberger-Dachs, Katherine S. Elliott, Isabelle Durieu, Nicole Fabien, Mathieu Fusaro, Maximilian Heeg, Yohan Schmitt, Marc Bras, Julian C. Knight, Jean-Christophe Lega, Gaetan Lesca, Anne-Laure Mathieu, Marion Moreews, Baptiste Moreira, Audrey Nosbaum, Matthew Page, Cécile Picard, T. Ronan Leahy, Isabelle Rouvet, Ethel Ryan, Damien Sanlaville, Klaus Schwarz, Andrew Skelton, Jean-Francois Viallard, Sebastien Viel, Marine Villard, Isabelle Callebaut, Capucine Picard, Thierry Walzer, Stephan Ehl, Alain Fischer, Bénédicte Neven, Alexandre Belot, Frédéric Rieux-Laucat
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
SOCS1 is a potent suppressor of JAK-STAT signalling responses to IFNγ and γ-chain cytokines and thereby limits inflammation. Here the authors identify and characterize heterozygous SOCS1 mutations in 10 patients from 5 unrelated families with autoi
Externí odkaz:
https://doaj.org/article/e099b2415a024179917630ee4d4f2ec2
Mumps Outbreaks in Vaccinated Populations—Is It Time to Re-assess the Clinical Efficacy of Vaccines?
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
History illustrates the remarkable public health impact of mass vaccination, by dramatically improving life expectancy and reducing the burden of infectious diseases and co-morbidities worldwide. It has been perceived that if an individual adhered to
Externí odkaz:
https://doaj.org/article/dacfda092a9a46728c44488bc10b4423
Autor:
Christian Klemann, Nadezhda Camacho-Ordonez, Linlin Yang, Zoya Eskandarian, Jessica L. Rojas-Restrepo, Natalie Frede, Alla Bulashevska, Maximilian Heeg, Moudjahed Saleh Al-Ddafari, Julian Premm, Maximilian Seidl, Sandra Ammann, Roya Sherkat, Nita Radhakrishnan, Klaus Warnatz, Susanne Unger, Robin Kobbe, Anja Hüfner, T. Ronan Leahy, Winnie Ip, Siobhan O. Burns, Manfred Fliegauf, Bodo Grimbacher
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining defi
Externí odkaz:
https://doaj.org/article/a2fc5ecf9ac44a21a75172989f793db7
Autor:
Dean Huggard, W. J. Koay, Lynne Kelly, Fiona McGrane, Emer Ryan, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Ana Moreno-Oliveira, Ashanty M. Melo, Derek G. Doherty, Eleanor J. Molloy
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Toll-like receptors (TLRs) are the key in initiating innate immune responses. TLR2 is crucial in recognising lipopeptides from gram-positive bacteria and is implicated in chronic inflammation. Children with Down syndrome (DS) are prone to infections
Externí odkaz:
https://doaj.org/article/cd7766bc5e2d439aac2a2e1030b657d0
Autor:
T A Leahy, A Chauhan, V Nicholas, P Patel, J Alcada, P Bianchi, F Caetano, S Desai, J Doyle, P Molyneux, S Ledot, S Padley, A Devaraj, C A Ridge, B Rawal, M Passariello, S Price, C Morgan, M Kokosi, B Patel, A Wells, G Ball, T Xu, A Bashir, C Remmington, S Singh
Publikováno v:
02.01 - Acute critical care.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388c3b491626e34a4eacdc8f58d3d355
https://doi.org/10.1183/13993003.congress-2022.2979
https://doi.org/10.1183/13993003.congress-2022.2979
Autor:
Hana Alachkar, Kathleen E. Sullivan, Claire Bethune, Erica Brittain, Niall Conlon, Neil Romberg, Claire Langley, Shanmuganathan Chandrakasan, Daniel Veltri, Matthew C. Cook, Bahar Miraghazadeh, Kelly D. Stone, Stefanie Frey-Jakobs, Jeffrey I. Cohen, Andrew L. Snow, Sinisa Savic, Sophie Hambleton, Maria Cecilia Poli, Arturo Borzutzky, Alexandra F. Freeman, Jeffrey R. Stinson, Michael B. Jordan, Michael A. Weinreich, T. Prescott Atkinson, Troy R. Torgerson, Michele P. Lambert, Alejandro A. Schäffer, T. Ronan Leahy, Celeste G Nelson, Peter D. Arkwright, Ivan K. Chinn, Stephan Weidinger, Laura Lucas, Tracy A Briggs, Martha Nason, Kenneth Paris, Smita Y. Patel, Sandhya Limaye, Sebastian Fuchs, Julia M. Hartberger, Bodo Grimbacher, Batsukh Dorjbal, Stephan Ehl, Amy Theos, Sergey Nejentsev, Andrew F. Whyte, Lena Moebus, Andrew J. Oler, Thomas DiMaggio, Joie Davis, Andre Franke, Chi Ma, Joshua D. Milner, Alla Bulashevska, Jeffrey D. Lebensburger
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:1482-1495
Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold protein in lymphocytes that links antigen receptor engagement with downstream signaling to nuclear factor κB, c-Jun N-terminal kinase, and mechanistic target of rapa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f399f0a51375745fd3767ab21c69a8a4
https://doi.org/10.1016/j.jaci.2018.08.013
https://doi.org/10.1016/j.jaci.2018.08.013
Autor:
Michelle Makiya, Sergio D. Rosenzweig, Maureen J. O'Sullivan, Chi Ma, Adam DeZure, Jennifer Stoddard, Joshua D. Milner, Alexandra F. Freeman, Julie E. Niemela, Amy D. Klion, Stefania Pittaluga, Sophie Hambleton, Brian Cauff, Mark Raffeld, Grainne M. O'Regan, Liqiang Xi, T. Ronan Leahy, Gary Kleiner
Publikováno v:
Blood. 129:650-653
To the editor: Somatic, gain-of-function mutations in STAT3 and STAT5 have been described in leukemias and lymphomas[1][1][⇓][2][⇓][3][⇓][4][⇓][5]-[6][6] and, more recently, in CD3-CD4+ T cells from a patient with lymphocytic variant hypereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f62ef78bd6adb55e37f4cfb2dfb078f
https://doi.org/10.1182/blood-2016-09-737817
https://doi.org/10.1182/blood-2016-09-737817
Autor:
Anna E. Smyth, Andrew J. Cant, T. Ronan Leahy, Colin J. McMahon, Kai Kisand, Aisling Snow, Epp Kaleviste
Publikováno v:
Journal of Clinical Immunology. 38:468-470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ddf51e77f86fa9e14feb18e9df33f31
https://doi.org/10.1007/s10875-018-0513-z
https://doi.org/10.1007/s10875-018-0513-z