Zobrazeno 1 - 10
of 82
pro vyhledávání: '"T A, Medsger"'
Publikováno v:
The Journal of Immunology. 158:485-491
Autoantibody responses to DNA topoisomerase I (Topo I) are highly specific to patients with systemic sclerosis (SSc). We recently demonstrated that Topo I-specific T cells are components of the T cell repertoire of patients with SSc and healthy indiv
Publikováno v:
The Journal of Immunology. 155:2703-2714
To elucidate the mechanisms controlling anti-DNA topoisomerase I (topo I) antibody production in patients with systemic sclerosis (SSc), in particular the role of interactions between topo I-specific Th cells and B cells, we established an in vitro s
Publikováno v:
Biochemical and Biophysical Research Communications. 212:220-228
We have screened human scleroderma patients for immunoreactivity with the components of the nucleus and the mitotic apparatus. We announce the identification of a novel cell-cycle-dependent nuclear protein using serum from a CREST patient AH. AH prot
Autor:
Y Okano, T A Medsger
Publikováno v:
The Journal of Immunology. 149:1093-1098
A class of RNA-containing particles, U small nuclear/nucleolar ribonucleoprotein particles (U snRNP), are well known to be targets for sera from patients with various autoimmune diseases. In the most cases the protein components carry the antigenic d
Autor:
Y Okano, T A Medsger
Publikováno v:
The Journal of Immunology. 146:535-542
We found serum autoantibodies directed against the proteins binding exclusively to U4/U6 of Sm small nuclear ribonucleoprotein particle (snRNP) in serum from a patient (MaS) with systemic sclerosis. Their specificity, called anti-MaS, is distinct fro
Autor:
Michael H. Weisman, V. Steen, D.L. Perlmutter, B. White, T. A. Medsger, Marc C. Hochberg, F.M. Wigley
Publikováno v:
Lupus. 4:454-456
The objective of this study was to estimate the prevalence of self-reported physician-diagnosed systemic lupus erythematosus (SLE) in the USA. During the conduct of an epidemiologic study of systemic sclerosis (scleroderma), 16607 randomly selected t
Publikováno v:
Arthritis care and research : the official journal of the Arthritis Health Professions Association. 13(3)
To determine whether the local Lupus Foundation of America (LFA) chapter would provide a unique source of additional lupus incident cases for a population-based incidence registry of SLE.We reviewed membership and telephone records from the LFA to id
Publikováno v:
Clinical and experimental rheumatology. 21(3 Suppl 29)
The Subcommittee members initially agreed on the concepts of disease activity, damage and severity, defining severity as the total effect of disease on organ function. It was decided to start with the assessment of severity using the Medsger's severi
Autor:
V D, Steen, T A, Medsger
Publikováno v:
Arthritis and rheumatism. 44(12)
The natural history of changes in skin thickening in diffuse scleroderma is quite variable, but the significance of these changes is not clear. Clinical trials are using changes in skin thickening as the primary outcome measure, and thus it would be
Autor:
E C, LeRoy, T A, Medsger
Publikováno v:
The Journal of rheumatology. 28(7)
We propose criteria for the early diagnosis and classification of systemic sclerosis that reflect the vascular and serological advances of the last 2 decades.