Zobrazeno 1 - 10
of 44
pro vyhledávání: '"T A, Krenitsky"'
Autor:
S. D. Chamberlain, A. R. Moorman, L. A. Jones, P. de Miranda, D. J. Reynolds, G. W. Koszalka, T. A. Krenitsky
Publikováno v:
Antiviral Chemistry and Chemotherapy. 3:371-378
6-Methoxypurine arabinoside [9-(β-D-arabinofuranosyl)-6-methoxy-9H-purine; 1] is a potent and selective agent against varicella-zoster virus in vitro. Studies in the rat indicated that extensive first pass metabolism of this nucleoside occurred afte
Publikováno v:
Biochemical Journal. 278:487-491
1. [2′-2H]Inosine was made from inosine by tetraisopropyldisiloxanyl protection of the 3′- and 5′-positions, oxidation with dimethyl sulphoxide and acetic anhydride, immediate NaB2H4 reduction of the oxo sugar product and inversion at C-2′ of
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(11)
Ganciclovir (GCV), which is used in the treatment of human cytomegalovirus infections, is poorly absorbed orally. A double prodrug of GCV, the dipivalate ester of 6-deoxy-GCV (6-dGCV) (called 6-dGCV-DPiv), was given orally to rats (25 mg/kg) and resu
Publikováno v:
Cancer research. 55(15)
Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated human T-leukemic cells. However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside
Autor:
G B, Roberts, J A, Fyfe, S A, McKee, S G, Rahim, S M, Daluge, M R, Almond, J L, Rideout, G W, Koszalka, T A, Krenitsky
Publikováno v:
Biochemical pharmacology. 46(12)
The varicella-zoster virus (VZV) thymidine kinase (TK) EC 2.7.2.21) catalyzes the phosphorylation of many anti-VZV nucleosides. Purified, bacterially expressed VZV TK was characterized with regard to N-terminal amino acid sequence, pI value, pH optim
Autor:
T. A. Krenitsky, G. W. Koszalka
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:xiii-xiv
Publikováno v:
The Journal of biological chemistry. 265(23)
The three-dimensional structure of thymidine phosphorylase from Escherichia coli has been determined at 2.8 A resolution using multiple-isomorphous-replacement techniques. The amino acid sequence deduced from the deoA DNA sequence is also reported. T
Publikováno v:
The Journal of biological chemistry. 265(6)
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major
Publikováno v:
Journal of Medicinal Chemistry. 26:1489-1494
Ribonucleosides of 4-(alkylthio)-1H-pyrazolo[3,4-d]pyrimidines have been shown to be useful anticoccidial agents [Krenitsky, T. A.; Rideout, J. L.; Koszalka, G. W.; Inmon, R. B.; Chao, E. Y.; Elion, G. B.; Latter, V. S.; Williams, R. B. J. Med. Chem.
Publikováno v:
Biochemical Journal. 257:355-359
1. alpha-Deuterium kinetic isotope effects on the phosphorolysis of inosine catalysed by Escherichia coli purine nucleoside phosphorylase were measured by the equilibrium-perturbation technique, by using the change in absorbance at 250 nm (approx. 20