Zobrazeno 1 - 10
of 10
pro vyhledávání: '"T A, Kocarek"'
Identification of a ubiquitination-Target/Substrate-interaction domain of cytochrome P-450 (CYP) 2E1
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(2)
Cytochrome P-450 (CYP) 2E1, the alcohol-inducible form of CYP, metabolizes a wide variety of endogenous substrates, therapeutic agents, protoxicants, and procarcinogens. CYP2E1 levels are post-transcriptionally elevated in response to certain xenobio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a95ba25cc5897ad178c6740db4a6055e
https://pubmed.ncbi.nlm.nih.gov/10640507
https://pubmed.ncbi.nlm.nih.gov/10640507
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(8)
Xenobiotics that induce the cytochromes P450 also produce changes in rat hepatic sulfotransferase (SULT) gene expression. In the present study, male Sprague-Dawley rats were treated for 3 consecutive days with doses of phenobarbital (PB) that induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::953d53bd8d63db7553c50d0639078220
https://pubmed.ncbi.nlm.nih.gov/9698295
https://pubmed.ncbi.nlm.nih.gov/9698295
Autor:
T A, Kocarek, A B, Reddy
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(11)
It was previously demonstrated that treatment of primary cultured rat hepatocytes with lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, induced the mRNAs for several cytochromes P450 (P450s), including CYP2B1/2, CYP3A1/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13c8d8a4e20dc1bd0200b3b40a66bbbf
https://pubmed.ncbi.nlm.nih.gov/8937853
https://pubmed.ncbi.nlm.nih.gov/8937853
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(10)
Because hormones have been implicated in the molecular regulation of the sulfotransferase multigene family, the effects of glucocorticoid and antiglucocorticoid hormones on rat hepatic hydroxysteroid sulfotransferase-a and aryl sulfotransferase IV ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e4ae2c50daccf70f7505a744a2c96b4
https://pubmed.ncbi.nlm.nih.gov/8894510
https://pubmed.ncbi.nlm.nih.gov/8894510
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(7)
Investigation of the posttranscriptional mechanisms involved in the xenobiotic-mediated enhancement of cytochrome P450 2E1 (CYP2E1) expression has been limited by a lack of a functional primary hepatocyte cell culture system. We examined the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3de3403c80e1aeba9a82b97fcab9967
https://pubmed.ncbi.nlm.nih.gov/7587954
https://pubmed.ncbi.nlm.nih.gov/7587954
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(3)
We previously demonstrated that induction of hepatic cytochrome P4503A (CYP3A) immunoreactive protein is a response in rats, but not rabbits, treated with the antiglucocorticoid, pregnenolone 16 alpha-carbonitrile and in rabbits, but not rats, treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86fcdf138fc1274f760ae8c725de9d01
https://pubmed.ncbi.nlm.nih.gov/7628309
https://pubmed.ncbi.nlm.nih.gov/7628309
Publikováno v:
BioTechniques. 18(3)
Poly(A) tail length is important in the stability and translation of mRNA. We describe procedures for the rapid and reproducible analysis of poly(A) tail length of a single mRNA species contained in a sample of total hepatic RNA. A short 3' fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99a7d4ffa802cc0611c6e0d1c61f80e3
https://pubmed.ncbi.nlm.nih.gov/7779397
https://pubmed.ncbi.nlm.nih.gov/7779397
Publikováno v:
Molecular pharmacology. 43(3)
Freshly isolated rat hepatocytes rapidly lose their cytochrome P450 (P450) proteins and mRNAs, with no evidence of subsequent restoration, after placement into traditional systems of primary culture on type I collagen. We examined the patterns of exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::405f120020b78b06526de940d5d84043
https://pubmed.ncbi.nlm.nih.gov/8450830
https://pubmed.ncbi.nlm.nih.gov/8450830
Publikováno v:
Molecular pharmacology. 40(2)
Cytochromes P450b and P450e (IIB1 and IIB2, respectively) are two remarkably similar microsomal hemoproteins whose inductions in rat liver are generally believed to be coordinately controlled by such xenobiotics as phenobarbital. To critically examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56d11c5a15d23d0cd20fd82ccbb82b2d
https://pubmed.ncbi.nlm.nih.gov/1715015
https://pubmed.ncbi.nlm.nih.gov/1715015
Publikováno v:
Molecular pharmacology. 38(4)
Phenobarbital induces cytochromes P450 (P450s) of not only the class IIB gene subfamily (i.e., P450b and P450e) but also the class IIIA gene subfamily (P450p and P450pcn2). To determine whether coinduction of these structurally dissimilar gene produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::899fcaa525b1d29963e80e4bb11fa3e6
https://pubmed.ncbi.nlm.nih.gov/2233686
https://pubmed.ncbi.nlm.nih.gov/2233686