Zobrazeno 1 - 10
of 293
pro vyhledávání: '"T Merkle"'
Publikováno v:
Cells, Vol 13, Iss 13, p 1156 (2024)
Primary cilia are finger-like sensory organelles that extend from the bodies of most cell types and have a distinct lipid and protein composition from the plasma membrane. This partitioning is maintained by a diffusion barrier that restricts the entr
Externí odkaz:
https://doaj.org/article/9ac479bc39694045899a881c54839b29
Autor:
Lydie Naulé, Alessandra Mancini, Sidney A. Pereira, Brandon M. Gassaway, John R. Lydeard, Kayleigh Rutherford, John C. Magnotto, Han Kyeol Kim, Joy Liang, Cynara Matos, Steven P. Gygi, Florian T. Merkle, Rona S. Carroll, Ana Paula Abreu, Ursula B. Kaiser
Publikováno v:
JCI Insight, Vol 8, Iss 8 (2023)
Makorin ring finger protein 3 (MKRN3) was identified as an inhibitor of puberty initiation with the report of loss-of-function mutations in association with central precocious puberty. Consistent with this inhibitory role, a prepubertal decrease in M
Externí odkaz:
https://doaj.org/article/8384957a66c14bedb6b66a209226aef3
Autor:
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.
Externí odkaz:
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Autor:
Edward C. Harding, Wei Ba, Reesha Zahir, Xiao Yu, Raquel Yustos, Bryan Hsieh, Leda Lignos, Alexei L. Vyssotski, Florian T. Merkle, Timothy G. Constandinou, Nicholas P. Franks, William Wisden
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
When mice are exposed to external warmth, nitric oxide synthase (NOS1) neurons in the median and medial preoptic (MnPO/MPO) hypothalamus induce sleep and concomitant body cooling. However, how these neurons regulate baseline sleep and body temperatur
Externí odkaz:
https://doaj.org/article/d4fc4cfb68234854865556a8642d363b
Autor:
Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M. Gribble, Frank Reimann, I. Sadaf Farooqi, Stephen O'Rahilly, Florian T. Merkle
Publikováno v:
Molecular Metabolism, Vol 17, Iss , Pp 82-97 (2018)
Objective: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POM
Externí odkaz:
https://doaj.org/article/a61f42e653954d9a945781cd864e4404
Autor:
Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L. Evans, Florian T. Merkle, Frank Reimann, Fiona M. Gribble, Clemence Blouet
Publikováno v:
Molecular Metabolism, Vol 10, Iss , Pp 14-27 (2018)
Objective: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which hypothalamic neural cir
Externí odkaz:
https://doaj.org/article/ca276ba2670243aeb41eb1b77aef2f9a
Autor:
Peter W. Andrews, Ivana Barbaric, Nissim Benvenisty, Jonathan S. Draper, Tenneille Ludwig, Florian T. Merkle, Yoji Sato, Claudia Spits, Glyn N. Stacey, Haoyi Wang, Martin F. Pera
Publikováno v:
Cell Stem Cell. 29:1624-1636
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research and therapy and the vast expansion in the number of hPSC lines availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac4cdee26d7c0b797dbccac88af902f
https://doi.org/10.1016/j.stem.2022.11.006
https://doi.org/10.1016/j.stem.2022.11.006
Autor:
Sara K. M. Jörgensen, Alena Karnošová, Simone Mazzaferro, Oliver Rowley, Hsiao-Jou Cortina Chen, Sarah J. Robbins, Sarah Christofides, Florian T. Merkle, Lenka Maletínská, David Petrik
Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, Diet Induced Obesity (DIO) by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18711e1703ec63ed9545667c4718bcf
https://doi.org/10.1101/2023.02.28.528936
https://doi.org/10.1101/2023.02.28.528936
Autor:
Joyce Hsiao, Ya Hu, Ning Wang, Amnon Koren, Andrew G. Clark, Alexa N. Bracci, Kevin Eggan, Florian T. Merkle, Michelle L Hulke, Matthew M. Edwards, Christine J. Charvet, Sulagna Ghosh, Dieter Egli, Qiliang Ding, Xiang Zhu, Robert E. Handsaker, Jeannine Gerhardt, Yao Tong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Funder: National Institute of Health (NIH) DP2-GM123495
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e3ee93deb4806288d949931a0bc770
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Autor:
Florian T. Merkle, Werner M. Neuhausser, David Santos, Eivind Valen, James A. Gagnon, Kristi Maas, Jackson Sandoe, Alexander F. Schier, Kevin Eggan
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 875-883 (2015)
The CRISPR-Cas9 system has the potential to revolutionize genome editing in human pluripotent stem cells (hPSCs), but its advantages and pitfalls are still poorly understood. We systematically tested the ability of CRISPR-Cas9 to mediate reporter gen
Externí odkaz:
https://doaj.org/article/24ec230e0413446e9677527a7ae44091