Zobrazeno 1 - 10 of 22 pro vyhledávání: '"T Conere"'
1
The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2
Autor: Shailendra Anoopkumar-Dukie, T. Conere, Catherine McDermott, Aileen Houston, Liam King, David R. H. Christie, Ashley Allshire
Publikováno v: Prostaglandins & Other Lipid Mediators. 148:106422
It is widely accepted that the hypoxic nature of solid tumors contribute to their resistance to radiation therapy. There is increasing evidence that cyclooxygenase-2 (COX-2) contributes to increased resistance of tumors to radiation therapy. Several
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93d7d5d2b64ef8101fa7daa01ec6d6a
https://doi.org/10.1016/j.prostaglandins.2020.106422
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2
Mitochondrial modulation of oxygen-dependent radiosensitivity in some human tumour cell lines
Autor: T. Conere, Ashley Allshire, Garry D. Sisk, Shailendra Anoopkumar-Dukie
Publikováno v: The British Journal of Radiology. 82:847-854
Oxygen-dependent radiosensitivity of tumour cells reflects direct oxidative damage to DNA, but non-nuclear mechanisms including signalling pathways may also contribute. Mitochondria are likely candidates because not only do they integrate signals fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f0947d11bf4c128498c8a907b20816
https://doi.org/10.1259/bjr/35746067
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3
Further evidence for biological effects resulting from ionizing radiation doses in the diagnostic X-ray range
Autor: T. Conere, A McMahon, Shailendra Anoopkumar-Dukie, Ashley Allshire
Publikováno v: The British Journal of Radiology. 78:335-337
In this study we assessed cell response to ionizing radiation doses in the diagnostic X-ray range, using metabolic performance as the biological end point. HeLa cells were irradiated between 3.5 mGy (standard deviation (SD=2.5%) and 55.1 mGy (SD=0.9%
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cbc0abc31df6ebc957dec71cdfd57b
https://doi.org/10.1259/bjr/24426084
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4
Resazurin assay of radiation response in cultured cells
Autor: John Carey, E O'Sullivan, F N van Pelt, T. Conere, Shailendra Anoopkumar-Dukie, Ashley Allshire
Publikováno v: The British journal of radiology. 78(934)
We describe use of resazurin reduction for measurement of cell response to irradiation as a simple and non-destructive assay that complements the conventional colony forming assay and can readily be applied to both adherent and non-adherent cell cult
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e2a2019c0c306caee4146eeed56db3
https://pubmed.ncbi.nlm.nih.gov/16177019
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5
Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines
Autor: Shailendra Anoopkumar-Dukie, T. Conere, John Carey, Ashley Allshire
Publikováno v: Free radical biologymedicine. 39(2)
Oxygen enhancement of tumor radiosensitivity is attributed to DNA damage by reactive oxygen species. The mechanism remains unclear but may involve mitochondria as major sources of oxygen and nitrogen radicals as well as central effectors of energy ho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b451b46893a0abfd4115f44c6afee90a
https://pubmed.ncbi.nlm.nih.gov/15964510
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10
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