Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tülin Tatar"'
Autor:
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activat
Externí odkaz:
https://doaj.org/article/9c882069fd714df8a02c424b20d4f84c
Autor:
Iris Müller, Ann Sophie Moroni, Daria Shlyueva, Sudeep Sahadevan, Erwin M. Schoof, Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Tülin Tatar, Richard P. Koche, Chang Huang, Kristian Helin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Naïve pluripotency is characterized by distinctly open chromatin and repressed endogenous retroviruses. Here the authors show that MPP8 and its association with the core HUSH complex is essential for naïve pluripotent cells; also that repression of
Externí odkaz:
https://doaj.org/article/9597bd4ec7404890a76dbc8df6a59f5c
Autor:
Andrea Corsinotti, Frederick CK Wong, Tülin Tatar, Iwona Szczerbinska, Florian Halbritter, Douglas Colby, Sabine Gogolok, Raphaël Pantier, Kirsten Liggat, Elham S Mirfazeli, Elisa Hall-Ponsele, Nicholas P Mullin, Valerie Wilson, Ian Chambers
Publikováno v:
eLife, Vol 6 (2017)
Deletion of Sox2 from mouse embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC)
Externí odkaz:
https://doaj.org/article/383310e3d27d44c8aad4b1b095ff1014
Autor:
Aliaksandra Radzisheuskaya, Jonas W. Højfeldt, Ann Sophie Moroni, Tülin Tatar, Sudeep Sahadevan, Daria Shlyueva, Chang Huang, Erwin M. Schoof, Richard Koche, Kristian Helin, Iris Müller
Publikováno v:
Nature Communications
Müller, I, Moroni, A S, Shlyueva, D, Sahadevan, S, Schoof, E M, Radzisheuskaya, A, Højfeldt, J W, Tatar, T, Koche, R P, Huang, C & Helin, K 2021, ' MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells ', Nature Communications, vol. 12, no. 1, 3034 . https://doi.org/10.1038/s41467-021-23308-4
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Müller, I, Moroni, A S, Shlyueva, D, Sahadevan, S, Schoof, E M, Radzisheuskaya, A, Højfeldt, J W, Tatar, T, Koche, R P, Huang, C & Helin, K 2021, ' MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells ', Nature Communications, vol. 12, 3034 . https://doi.org/10.1038/s41467-021-23308-4
Müller, I, Moroni, A S, Shlyueva, D, Sahadevan, S, Schoof, E M, Radzisheuskaya, A, Højfeldt, J W, Tatar, T, Koche, R P, Huang, C & Helin, K 2021, ' MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells ', Nature Communications, vol. 12, no. 1, 3034 . https://doi.org/10.1038/s41467-021-23308-4
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Müller, I, Moroni, A S, Shlyueva, D, Sahadevan, S, Schoof, E M, Radzisheuskaya, A, Højfeldt, J W, Tatar, T, Koche, R P, Huang, C & Helin, K 2021, ' MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells ', Nature Communications, vol. 12, 3034 . https://doi.org/10.1038/s41467-021-23308-4
Deciphering the mechanisms that control the pluripotent ground state is key for understanding embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse embryonic stem cells (mESCs) is not fully understood. Here, we identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2801ad5c1f10504ceddc578d55a3af42
https://pubmed.ncbi.nlm.nih.gov/34031396
https://pubmed.ncbi.nlm.nih.gov/34031396
Autor:
Chia-Yi Lin, Guillaume Blin, Rosa Portero Migueles, Tülin Tatar, Ian Chambers, Hongyu Shao, Mattias Malaguti, Sally Lowell, Naiming Chen
SummaryPluripotent cells reorganise themselves into an epithelium before they initiate differentiation, but it is not clear how these two events are mechanistically linked. Here we use quantitative imaging approaches to measure cellular rearrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb26064328baeafa61e3217f685b4c8
https://doi.org/10.1101/809467
https://doi.org/10.1101/809467
Publikováno v:
Mol Cell
The Polycomb repressive complex 2 (PRC2) catalyzes H3K27 methylation across the genome, which impacts transcriptional regulation and is critical for establishment of cell identity. Because of its essential function during development and in cancer, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f391c8795f4d0380a54e740b638229fa
https://europepmc.org/articles/PMC6842426/
https://europepmc.org/articles/PMC6842426/
Publikováno v:
Life Science Alliance
Expression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles.
Tet1, Tet2, and Tet3 encode DNA demethylases that play critical roles during stem cell differentiation and reprogramming to pluripotency
Tet1, Tet2, and Tet3 encode DNA demethylases that play critical roles during stem cell differentiation and reprogramming to pluripotency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2c229ec3bf62eb2156d4e4b1d74ed8d
https://pubmed.ncbi.nlm.nih.gov/31582397
https://pubmed.ncbi.nlm.nih.gov/31582397
Autor:
Ian Chambers, Elisa Hall-Ponsele, Frederick C. K. Wong, Tülin Tatar, Andrea Corsinotti, Douglas Colby, Raphaël Pantier, Florian Halbritter, Valerie Wilson, Iwona Szczerbinska, Elham S Mirfazeli, Sabine Gogolok, Nicholas P. Mullin, Kirsten Liggat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614f7d44bebdb95d54069de9b42baff0
https://doi.org/10.7554/elife.27746.034
https://doi.org/10.7554/elife.27746.034
Autor:
Elisa Hall-Ponsele, Frederick C. K. Wong, Elham S Mirfazeli, Tülin Tatar, Sabine Gogolok, Iwona Szczerbinska, Andrea Corsinotti, Nicholas P. Mullin, Douglas Colby, Ian Chambers, Raphaël Pantier, Kirsten Liggat, Florian Halbritter, Valerie Wilson
Publikováno v:
eLife, Vol 6 (2017)
eLife
Corsinotti, A, Wong, F C K, Tatar, T, Szczerbinska, I, Halbritter, F, Colby, D, Gogolok, S, Pantier, R, Liggat, K, Mirfazeli, E S, Hall-Ponsele, E, Mullin, N P, Wilson, V & Chambers, I 2017, ' Distinct SoxB1 networks are required for naïve and primed pluripotency ', eLIFE, vol. 6, e27746 . https://doi.org/10.7554/eLife.27746
eLife
Corsinotti, A, Wong, F C K, Tatar, T, Szczerbinska, I, Halbritter, F, Colby, D, Gogolok, S, Pantier, R, Liggat, K, Mirfazeli, E S, Hall-Ponsele, E, Mullin, N P, Wilson, V & Chambers, I 2017, ' Distinct SoxB1 networks are required for naïve and primed pluripotency ', eLIFE, vol. 6, e27746 . https://doi.org/10.7554/eLife.27746
Deletion ofSox2from embryonic stem cells (ESCs) causes trophectodermal differentiation. While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a180991f2682a4fc72bbd5d1d1f466
https://elifesciences.org/articles/27746
https://elifesciences.org/articles/27746
Publikováno v:
Pantier, R, Tatar, T, Colby, D & Chambers, I 2019, ' Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker ', Life Science Alliance, vol. 2, no. 5, e201900516 . https://doi.org/10.26508/lsa.201900516
Tet1, Tet2, and Tet3 encode DNA demethylases that play critical roles during stem cell differentiation and reprogramming to pluripotency. Although all three genes are transcribed in pluripotent cells, little is known about the expression of the corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2301d1175792b869d7b7d48f3feb08
https://doi.org/10.26508/lsa.201900516
https://doi.org/10.26508/lsa.201900516