The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

Autor: Pedro Xavier-Elsas, Cássio Luiz Coutinho Almeida da Silva, Bruno Marques Vieira, Daniela Masid-de-Brito, Túlio Queto, Bianca de Luca, Thiago Soares de Souza Vieira, Maria Ignez C. Gaspar-Elsas

Publikováno v: Mediators of Inflammation, Vol 2015 (2015)

Exogenously administered glucocorticoids enhance eosinophil and neutrophil granulocyte production from murine bone-marrow. A hematological response dependent on endogenous glucocorticoids underlies bone-marrow eosinophilia induced by trauma or allerg

Externí odkaz: https://doaj.org/article/72477e1632114c1a92ad391de0716ddf

Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents

Autor: Bianca de Luca, Pedro Xavier-Elsas, Mônica Barradas, Ricardo A. Luz, Túlio Queto, Carla Jones, Maria Augusta Arruda, Thiago Mattar Cunha, Fernando Queiroz Cunha, Maria Ignez Gaspar-Elsas

Publikováno v: The Scientific World Journal, Vol 2013 (2013)

Up- and downregulation of eosinopoiesis control pulmonary eosinophilia in human asthma. In mice, eosinopoiesis is suppressed in vitro by prostaglandin E2 (PGE2) and in vivo by diethylcarbamazine, through a proapoptotic mechanism sequentially requirin

Externí odkaz: https://doaj.org/article/84ce1afd2f394b33a3fb8851537d3abd

G-CSF suppresses allergic pulmonary inflammation, downmodulating cytokine, chemokine and eosinophil production

Autor: Pedro Xavier-Elsas, Ricardo Alves Luz, Julia Farache, Patrícia M.R. e Silva, Adriana Bonomo, Túlio Queto, Carina Anselmo, Zilton Vasconcelos, Ana Amélia A. Guiné, Maria Ignez C. Gaspar-Elsas, Jose Marcos T. Cunha

Publikováno v: Life Sciences. 88:830-838

article i nfo Article history: Received 17 September 2010 Accepted 2 March 2011 Aims: Granulocyte Colony-Stimulating Factor (G-CSF), which mobilizes hemopoietic stem cells (HSC), is believed to protect HSC graft recipients from graft-versus-host dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bf9b78761f6e07f0e5d1020c52e329
https://doi.org/10.1016/j.lfs.2011.03.001

Blockage of Eosinopoiesis by IL-17A Is Prevented by Cytokine and Lipid Mediators of Allergic Inflammation

Autor: Fernando Q. Cunha, Maria Ignez Gaspar-Elsas, Túlio Queto, Elizabeth Chen Dahab, Bianca de Luca, Pedro Xavier-Elsas, José Carlos Farias Alves Filho, Daniela Masid-de-Brito, Bruno Marques Vieira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Mediators of Inflammation, Vol 2015 (2015)
Mediators of Inflammation

Interleukin- (IL-) 17A, a pleiotropic mediator of inflammation and autoimmunity, potently stimulates bone-marrow neutrophil production. To explore IL-17A effects on eosinopoiesis, we cultured bone-marrow from wild-type mice, or mutants lacking induci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4687233038d11ae19edfd2374104020

Essential roles of endogenous glucocorticoids and TNF/TNFR1 in promoting bone-marrow eosinopoiesis in ovalbumin-sensitized, airway-challenged mice

Autor: Túlio Queto, Pedro Xavier-Elsas, Ricardo Alves Luz, Bruno Marques Vieira, Cássio Luiz Coutinho Almeida da Silva, Rodrigo Lopes, Maria Ignez C. Gaspar-Elsas, Daniela Masid-de-Brito

Publikováno v: Life sciences. 94(1)

Aims Stress mechanisms paradoxically contribute to allergic episodes in humans and mice. Glucocorticoids (GC) and interleukin (IL)-5 synergically upregulate murine bone-marrow eosinophil production. Here we explored the role of endogenous GC in aller

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd88ac2ff7f288c9c35de1d5bab39fc0
https://pubmed.ncbi.nlm.nih.gov/24239638