Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Tímea Polgár"'
Autor:
Artur Jóźwik, Maurizio Battino, Ioana Berindan-Neagoe, Andy Wai Kan Yeung, Olaf K. Horbańczuk, Silvestre Sampino, Nikolay T. Tzvetkov, Ferdinando Nicoletti, Atanas G. Atanasov, Magdalena D. Pieczynska, Tímea Polgár
Publikováno v:
International Journal of Food Sciences and Nutrition. 71:13-21
Total-scale quantitative research literature analysis on the food toxicology scientific field has yet to be conducted. In this work, we identified and analysed food toxicology publications in the existing scientific literature. A literature search wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27caf910adcb8451ba1a820ab564151
https://doi.org/10.1080/09637486.2019.1620184
https://doi.org/10.1080/09637486.2019.1620184
Publikováno v:
XV. Magyar Gyógynövény Konferencia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8010b550f850279647d0748ea7941db
https://doi.org/10.14232/mgyk.2018.e5
https://doi.org/10.14232/mgyk.2018.e5
Publikováno v:
Journal of Chemical Information and Modeling. 54:1036-1049
3D shape- or volume-based virtual screening is a broadly used approach in drug discovery. In recent years a large number of publications have appeared in which these tools were compared not only to competitive methods but to docking studies as well.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92f53d131645041d1da6cf444db5064
https://doi.org/10.1021/ci400620f
https://doi.org/10.1021/ci400620f
Autor:
Anurima Majumder, György M. Keserü, Andrew T. Magis, Tímea Polgár, Robert W. Allan, Lakshmanan Govindasamy, Peter P. Sayeski, Mavis Agbandje-McKenna, Rebekah Baskin, Kirpal S. Bisht, Gary W. Reuther, Robert Kiss
Publikováno v:
Journal of Biological Chemistry. 285:31399-31407
Somatic mutations in the Jak2 protein, such as V617F, cause aberrant Jak/STAT signaling and can lead to the development of myeloproliferative neoplasms. This discovery has led to the search for small molecule inhibitors that target Jak2. Using struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e81744b82cb001dc2fc18e786b5246b
https://doi.org/10.1074/jbc.m110.168211
https://doi.org/10.1074/jbc.m110.168211
Autor:
Jacqueline Sayyah, Annet Kirabo, Lubomir Sokol, Alan F. List, Kirpal S. Bisht, Róbert Gábor Kiss, György M. Keserü, Kenneth S. Zuckerman, Peter P. Sayeski, Nicholas C. Figueroa, Tímea Polgár, Meghanath Gali
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3598-3601
Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematologic malignancies. A somatic mutation of JAK2 (Val617Phe) was previously shown to occur in 98% of patients with polycythemia vera and 50% of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b4168d1b7f8388d3b88963aac73132
https://doi.org/10.1016/j.bmcl.2009.04.138
https://doi.org/10.1016/j.bmcl.2009.04.138
Autor:
Tímea Polgár, Gyoergy M. Keserue
Publikováno v:
Journal of Chemical Information and Modeling. 46:1795-1805
One of the main complicating factors in structure-based drug design is the conformational rearrangement of the receptor upon ligand binding implicating protein flexibility as a crucial component in virtual screening. The FlexE approach allows flexibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba34849da8ad4e483aacc5e7f41f130
https://doi.org/10.1021/ci050412x
https://doi.org/10.1021/ci050412x
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 725:239-242
A functional virtual screen was developed using FlexX-Pharm/ChemScore that separates ligands taking advantage of the different binding modes between estrogen receptor alpha agonists and antagonists. Increased performance of FlexX-Pharm over FlexX was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0c5fa49bb2272794bc3165877abeef
https://doi.org/10.1016/j.theochem.2005.02.083
https://doi.org/10.1016/j.theochem.2005.02.083
Synergistic Effect of Avemar on Proinflammatory Cytokine Production and Ras-Mediated Cell Activation
Autor:
Erzsébet Kusz, Tímea Polgár, Eva E. Qwarnstrom, Steven K. Dower, Akos Resetar, Endre Kiss-Toth, Erno Duda, András Telekes, Tünde Nagy
Publikováno v:
Annals of the New York Academy of Sciences. 1051:515-528
Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf008828361ec0a41266ed3007e4c10
https://doi.org/10.1196/annals.1361.096
https://doi.org/10.1196/annals.1361.096
Autor:
Eva E. Qwarnstrom, Hye Youn Sung, Steven K. Dower, Mary T. Harte, Tímea Polgár, Veronika Jozsa, Stephanie M. Bagstaff, Endre Kiss-Toth, Clare Dempsey, Jim C. Caunt, David H. Wyllie, Kevin M. Oxley, Luke A. J. O'Neill
Publikováno v:
Journal of Biological Chemistry. 279:42703-42708
PUBLISHED
Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulat
Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with Trbs and regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c40dcd5afc5869bc54fb2b8f73558d7
https://doi.org/10.1074/jbc.m407732200
https://doi.org/10.1074/jbc.m407732200
Autor:
Tímea, Polgár, György M, Keseru
Publikováno v:
Current pharmaceutical design. 20(20)
Alois Alzheimer identified first abnormal deformation in the brain of diseased people with mental disorder. The disorder is clinically characterized by a progression from episodic memory problems to a slow global decline of cognitive function, ending
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b97098daaf541f84c0ebc6f3567426a
https://pubmed.ncbi.nlm.nih.gov/23947643
https://pubmed.ncbi.nlm.nih.gov/23947643