Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tímea Feller"'
Autor:
Matt D. G. Hughes, Sophie Cussons, Benjamin S. Hanson, Kalila R. Cook, Tímea Feller, Najet Mahmoudi, Daniel L. Baker, Robert Ariëns, David A. Head, David J. Brockwell, Lorna Dougan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Fibrous networks constructed from high aspect ratio protein building blocks are ubiquitous in nature. Despite this ubiquity, the functional advantage of such building blocks over globular proteins is not understood. To answer this question,
Externí odkaz:
https://doaj.org/article/75078bc47eed4e7291592f100c7a7a87
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7296 (2024)
Von Willebrand factor (VWF) is a multimer with a variable number of protomers, each of which is a head-to-head dimer of two multi-domain monomers. VWF responds to shear through the unfolding and extension of distinct domains, thereby mediating platel
Externí odkaz:
https://doaj.org/article/515664eaeb79487096a0cf4f7ba75ae9
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:6-16
Polymeric fibrin displays unique structural and biomechanical properties that contribute to its essential role of generating blood clots that stem bleeds. The aim of this review is to discuss how the fibrin clot is formed, how protofibrils make up in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d34551d1d1716936a2d2cb429b479da
https://doi.org/10.1111/jth.15531
https://doi.org/10.1111/jth.15531
Autor:
Mária Csilla Csányi, Pál Salamon, Tímea Feller, Tamás Bozó, Jolán Hársfalvi, Miklós S. Z. Kellermayer
Publikováno v:
Protein Science. 32
The von Willebrand factor (VWF) is a multimeric glycoprotein composed of 80- to 120-nm-long protomeric units and plays a fundamental role in mediating platelet function at high shear. The exact nature of the shear-induced structural transitions have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2c6081439995548d62e43368d6082f
https://doi.org/10.1002/pro.4535
https://doi.org/10.1002/pro.4535
Autor:
Imre Varjú, Erzsébet Tóth, Ádám Z. Farkas, Veronika J. Farkas, Erzsébet Komorowicz, Tímea Feller, Balázs Kiss, Miklós Z. Kellermayer, László Szabó, András Wacha, Attila Bóta, Colin Longstaff, Krasimir Kolev
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 20(12)
Fibrin, the main scaffold of thrombi, is susceptible to citrullination by PAD (peptidyl arginine deiminase) 4, secreted from neutrophils during the formation of neutrophil extracellular traps. Citrullinated fibrinogen (citFg) has been detected in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc4b0c67f41794a4fbf0839977afdb5
https://pubmed.ncbi.nlm.nih.gov/36083779
https://pubmed.ncbi.nlm.nih.gov/36083779
Autor:
Krasimir Kolev, Á. Farkas, Balázs Kiss, Imre Varjú, Deya Cherpokova, Veronika J. Farkas, Attila Bóta, Colin Longstaff, Erzsébet Komorowicz, Nicoletta Sorvillo, Tímea Feller, András Wacha, László Szabó, Denisa D. Wagner, Miklós Z. Kellermayer
Publikováno v:
Circulation Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446b14f2932991fcbc68704f48a006f0
https://doi.org/10.1161/circresaha.121.319061
https://doi.org/10.1161/circresaha.121.319061
Autor:
Nadira Yuldasheva, Victoria Ridger, Adomas Baranauskas, Simon D. Connell, Majid Ali, Richard M Cubbon, Stephen R. Baker, Ramzi A. Ajjan, Zaher Raslan, Helen Philippou, Cédric Duval, Helen R. McPherson, Khalid M. Naseem, Marc A. Bailey, Tímea Feller, Lih T. Cheah, Robert A. S. Ariëns
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Pulmonary embolism and stroke are thromboembolic diseases affecting >1 million people annually worldwide. Thromboembolism involves clot fragments affecting vital downstream organs such as the lung or brain. The mechanisms underpinning th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f3d938469db476b95359a06559028f
http://europepmc.org/articles/PMC8271579
http://europepmc.org/articles/PMC8271579
Publikováno v:
Biophysical Journal. 121:453a-454a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe679920aa7129024c615b7528ceeb9a
https://doi.org/10.1016/j.bpj.2021.11.526
https://doi.org/10.1016/j.bpj.2021.11.526
Publikováno v:
Journal of Structural Biology. 203:273-280
Fibrin plays a fundamentally important role during hemostasis. To withstand the shear forces of blood flow and prevent embolisation, fibrin monomers form a three-dimensional polymer network that serves as an elastic scaffold for the blood clot. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8e2f23b11b1a19ad14dc62e39a0a6e
https://doi.org/10.1016/j.jsb.2018.05.010
https://doi.org/10.1016/j.jsb.2018.05.010
Autor:
Gael B. Morrow, Timea Feller, Zoe McQuilten, Elizabeth Wake, Robert A. S. Ariëns, James Winearls, Nicola J. Mutch, Mike A. Laffan, Nicola Curry
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)
Abstract Background Fibrinogen is the first coagulation protein to reach critical levels during traumatic haemorrhage. This laboratory study compares paired plasma samples pre- and post-fibrinogen replacement from the Fibrinogen Early In Severe Traum
Externí odkaz:
https://doaj.org/article/2400862b5d3c498298e4fb2284d6e9c2